Publications by authors named "Dennis Keefe"

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CTx001 for Geographic Atrophy: A Gene Therapy Expressing Soluble, Truncated Complement Receptor 1 (Mini-CR1).
Sonika Rathi, Athanasios Didangelos, Sofiya Pisarenka, Rachel Green, Stamatia Zafeiri, Dennis Keefe

Ophthalmol Sci· January 2026

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Pilot dose-ranging of rhIGF-1/rhIGFBP-3 in a preterm lamb model of evolving bronchopulmonary dysplasia.
Kurt H Albertine, Mar Janna Dahl, Andrew Rebentisch, Elaine Dawson, Akbar Nabi, Dennis Keefe

Pediatr Res· May 2023

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SBT-272 improves TDP-43 pathology in ALS upper motor neurons by modulating mitochondrial integrity, motility, and function.
Mukesh Gautam, Barış Genç, Benjamin Helmold, Angela Ahrens, Janis Kuka, Dennis Keefe

Neurobiol Dis· March 2023

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VEGFR-1/Flt-1 inhibition increases angiogenesis and improves muscle function in a mouse model of Duchenne muscular dystrophy.
Jennifer Bosco, Zhiwei Zhou, Sofie Gabriëls, Mayank Verma, Nan Liu, Dennis Keefe

Mol Ther Methods Clin Dev· June 2021

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The effects of a mitochondrial targeted peptide (elamipretide/SS31) on BAX recruitment and activation during apoptosis.
Joshua A Grosser, Rachel L Fehrman, Dennis Keefe, Martin Redmon, Robert W Nickells

BMC Res Notes· May 2021

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Inhibition of FLT1 ameliorates muscular dystrophy phenotype by increased vasculature in a mouse model of Duchenne muscular dystrophy.
Mayank Verma, Yuko Shimizu-Motohashi, Yoko Asakura, James P Ennen, Jennifer Bosco, Dennis Keefe

PLoS Genet· December 2019

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Anti-sFlt-1 Therapy Preserves Lung Alveolar and Vascular Growth in Antenatal Models of Bronchopulmonary Dysplasia.
Bradley Wallace, Amelie Peisl, Gregory Seedorf, Taylor Nowlin, Christina Kim, Dennis Keefe

Am J Respir Crit Care Med· March 2018

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A new approach to synergize academic and guideline-compliant research: the CLARITY-BPA research program.
Thaddeus T Schug, Jerrold J Heindel, Luísa Camacho, K Barry Delclos, Paul Howard, Dennis Keefe

Reprod Toxicol· September 2013

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Perforin pores in the endosomal membrane trigger the release of endocytosed granzyme B into the cytosol of target cells.
Jerome Thiery, Dennis Keefe, Steeve Boulant, Emmanuel Boucrot, Michael Walch

Nat Immunol· June 2011

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In vitro characterization of an acetylcholine receptor-transferrin fusion protein for the treatment of myasthenia gravis.
Dennis Keefe, Chuenlei Parng, Dianna Lundberg, Satyajit Ray, Jennifer Martineau-Bosco

Autoimmunity· December 2010

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Perforin activates clathrin- and dynamin-dependent endocytosis, which is required for plasma membrane repair and delivery of granzyme B for granzyme-mediated apoptosis.
Jerome Thiery, Dennis Keefe, Saviz Saffarian, Denis Martinvalet, Michael Walch

Blood· February 2010

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A rapid, fluorescence-based assay for detecting antigenic modulation of the acetylcholine receptor on human cell lines.
Dennis Keefe, Donna Hess, Jennifer Bosco, Socrates Tzartos, Jan Powell

Cytometry B Clin Cytom· May 2009

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Granzyme A, which causes single-stranded DNA damage, targets the double-strand break repair protein Ku70.
Pengcheng Zhu, Dong Zhang, Dipanjan Chowdhury, Denis Martinvalet, Dennis Keefe

EMBO Rep· April 2006

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Perforin triggers a plasma membrane-repair response that facilitates CTL induction of apoptosis.
Dennis Keefe, Lianfa Shi, Stefan Feske, Ramiro Massol, Francisco Navarro

Immunity· September 2005

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Speaking your patients' language. A Massachusetts health system bridges linguistic and cultural gaps.
Dennis Keefe

Healthc Exec· August 2005

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Granzyme B binds to target cells mostly by charge and must be added at the same time as perforin to trigger apoptosis.
Lianfa Shi, Dennis Keefe, Enrique Durand, Hanping Feng, Dong Zhang

J Immunol· May 2005

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