Publications by authors named "Dennis Simpson"

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Deficiency Induces Oncogenic R-Loop Dependent Synthetic Lethality with PARP1 Inhibitors.
Gaorav Gupta, Qinhong Wang, Simon Ellington, Paolo Guerra, Faeze Gharibpoor, Dennis Simpson

Res Sq· July 2025

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Hierarchical Coordination of Polymerase Theta and RAD51 Resolves Clustered Replication Fork Collapse.
Chelsea M Smith, Dennis A Simpson, Paolo Guerra, Wanjuan Feng, Simon W Ellington

bioRxiv· July 2025

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MRE11 liberates cGAS from nucleosome sequestration during tumorigenesis.
Min-Guk Cho, Rashmi J Kumar, Chien-Chu Lin, Joshua A Boyer, Jamshaid A Shahir, Dennis A Simpson

Nature· January 2024

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Genetic separation of Brca1 functions reveal mutation-dependent Polθ vulnerabilities.
John J Krais, David J Glass, Ilse Chudoba, Yifan Wang, Wanjuan Feng, Dennis Simpson

Nat Commun· November 2023

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Targeting Non-homologous and Alternative End Joining Repair to Enhance Cancer Radiosensitivity.
Wanjuan Feng, Chelsea M Smith, Dennis A Simpson, Gaorav P Gupta

Semin Radiat Oncol· January 2022

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Marker-free quantification of repair pathway utilization at Cas9-induced double-strand breaks.
Wanjuan Feng, Dennis A Simpson, Jang-Eun Cho, Juan Carvajal-Garcia, Chelsea M Smith

Nucleic Acids Res· May 2021

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Dual inhibition of DNA-PK and DNA polymerase theta overcomes radiation resistance induced by p53 deficiency.
Rashmi J Kumar, Hui Xiao Chao, Dennis A Simpson, Wanjuan Feng, Min-Guk Cho

NAR Cancer· December 2020

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Estimating relative CWD susceptibility and disease progression in farmed white-tailed deer with rare PRNP alleles.
Nicholas J Haley, Kahla Merrett, Amy Buros Stein, Dennis Simpson, Andrew Carlson

PLoS One· March 2020

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A P53-Independent DNA Damage Response Suppresses Oncogenic Proliferation and Genome Instability.
Katerina D Fagan-Solis, Dennis A Simpson, Rashmi J Kumar, Luciano G Martelotto, Lisle E Mose

Cell Rep· February 2020

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Genetic determinants of cellular addiction to DNA polymerase theta.
Wanjuan Feng, Dennis A Simpson, Juan Carvajal-Garcia, Brandon A Price, Rashmi J Kumar

Nat Commun· September 2019

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Patterns of cell cycle checkpoint deregulation associated with intrinsic molecular subtypes of human breast cancer cells.
Jacquelyn J Bower, Leah D Vance, Matthew Psioda, Stephanie L Smith-Roe, Dennis A Simpson

NPJ Breast Cancer· March 2017

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Effective intra-S checkpoint responses to UVC in primary human melanocytes and melanoma cell lines.
Marila Cordeiro-Stone, John J McNulty, Christopher D Sproul, Paul D Chastain, Eugene Gibbs-Flournoy, Dennis A Simpson

Pigment Cell Melanoma Res· January 2016

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Oncogenic BRAF(V600E) Induces Clastogenesis and UVB Hypersensitivity.
Dennis A Simpson, Nathalay Lemonie, David S Morgan, Shobhan Gaddameedhi, William K Kaufmann

Cancers (Basel)· June 2015

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SWI/SNF complexes are required for full activation of the DNA-damage response.
Stephanie L Smith-Roe, Jun Nakamura, Darcy Holley, Paul D Chastain, Gary B Rosson, Dennis A Simpson

Oncotarget· January 2015

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Mechanisms of chromosomal instability in melanoma.
William K Kaufmann, Craig C Carson, Bernard Omolo, Adam J Filgo, Maria J Sambade, Dennis A Simpson

Environ Mol Mutagen· July 2014

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Gene expression signatures but not cell cycle checkpoint functions distinguish AT carriers from normal individuals.
Liwen Zhang, Dennis A Simpson, Cynthia L Innes, Jeff Chou, Pierre R Bushel

Physiol Genomics· October 2013

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A prognostic signature of G(2) checkpoint function in melanoma cell lines.
Bernard Omolo, Craig Carson, Haitao Chu, Yingchun Zhou, Dennis A Simpson

Cell Cycle· April 2013

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A predictive mathematical model of the DNA damage G2 checkpoint.
Kevin J Kesseler, Michael L Blinov, Timothy C Elston, William K Kaufmann, Dennis A Simpson

J Theor Biol· March 2013

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Separation of intra-S checkpoint protein contributions to DNA replication fork protection and genomic stability in normal human fibroblasts.
Stephanie L Smith-Roe, Shivani S Patel, Yingchun Zhou, Dennis A Simpson, Shangbang Rao

Cell Cycle· January 2013

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A flexible and qualitatively stable model for cell cycle dynamics including DNA damage effects.
Clark D Jeffries, Charles R Johnson, Tong Zhou, Dennis A Simpson, William K Kaufmann

Gene Regul Syst Bio· August 2012

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A prognostic signature of defective p53-dependent G1 checkpoint function in melanoma cell lines.
Craig Carson, Bernard Omolo, Haitao Chu, Yingchun Zhou, Maria J Sambade, Dennis A Simpson

Pigment Cell Melanoma Res· July 2012

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Timeless functions independently of the Tim-Tipin complex to promote sister chromatid cohesion in normal human fibroblasts.
Stephanie L Smith-Roe, Shivani S Patel, Dennis A Simpson, Ying Chun Zhou, Shangbang Rao

Cell Cycle· May 2011

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Revised genetic requirements for the decatenation G2 checkpoint: the role of ATM.
Jacquelyn J Bower, Yingchun Zhou, Tong Zhou, Dennis A Simpson, Sonnet J Arlander

Cell Cycle· April 2010

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Human papilloma virus type16 E6 deregulates CHK1 and sensitizes human fibroblasts to environmental carcinogens independently of its effect on p53.
Bo Chen, Dennis A Simpson, Yingchun Zhou, Amritava Mitra, David L Mitchell

Cell Cycle· June 2009

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In silico construction of a protein interaction landscape for nucleotide excision repair.
Nancy Tran, Ping-Ping Qu, Dennis A Simpson, Laura Lindsey-Boltz, Xiaojun Guan

Cell Biochem Biophys· March 2009

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