Publications by Derek B Lowe | PubHawk

Publications by authors named "Derek B Lowe"

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Mimicking Complex Receptor Actions with Small(ish) Molecules.

N Engl J Med· September 2025

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Design and Synthesis of a Novel Series of Orally Bioavailable, CNS-Penetrant, Isoform Selective Phosphoinositide 3-Kinase γ (PI3Kγ) Inhibitors with Potential for the Treatment of Multiple Sclerosis (MS).

Jon H Come, Philip N Collier, James A Henderson, Albert C Pierce, Robert J Davies, Derek B Lowe

J Med Chem· June 2018

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Introducing Biochemistry to Bedside.

Biochemistry· February 2018

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Drug discovery: Combichem all over again.

Nat Chem· October 2014

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Nowhere to go but up: the return of medicinal chemistry.

ACS Med Chem Lett· January 2012

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Quinazolinone derivatives as orally available ghrelin receptor antagonists for the treatment of diabetes and obesity.

Joachim Rudolph, William P Esler, Stephen O'connor, Philip D G Coish, Philip L Wickens, Derek B Lowe

J Med Chem· October 2007

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4,5-Disubstituted cis-pyrrolidinones as inhibitors of type II 17beta-hydroxysteroid dehydrogenase. Part 3. Identification of lead candidate.

Jill Wood, Cedo M Bagi, Christiana Akuche, Antonietta Bacchiocchi, Jeremy Baryza, Derek B Lowe

Bioorg Med Chem Lett· September 2006

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Substituted indanylacetic acids as PPAR-alpha-gamma activators.

Derek B Lowe, Neil Bifulco, William H Bullock, Thomas Claus, Philip Coish

Bioorg Med Chem Lett· January 2006

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Specific inhibition of hormone-sensitive lipase improves lipid profile while reducing plasma glucose.

Thomas H Claus, Derek B Lowe, Yin Liang, Arthur I Salhanick, Christine Keiper Lubeski

J Pharmacol Exp Ther· December 2005

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In vitro SAR of (5-(2H)-isoxazolonyl) ureas, potent inhibitors of hormone-sensitive lipase.

Derek B Lowe, Steven Magnuson, Ning Qi, Ann-Marie Campbell, James Cook

Bioorg Med Chem Lett· June 2004

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