Publications by authors named "Derek Best"

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Legacy hERG study data in contemporary integrated risk assessments - mitigating the risk of protocol and positive control article differences.
Richard W Daniels, James W Kramer, Matthew M Abernathy, Derek D Best, Jessica C Brimecombe

J Pharmacol Toxicol Methods· September 2025

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Telemetry in toxicology studies - A comparison of data across species, technologies and time.
Derek D Best, Matthew M Abernathy, Derek J Leishman

J Pharmacol Toxicol Methods· June 2025

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The statistical and pharmacological sensitivity of nonclinical QTc analysis comparing jacketed telemetry and multilead snapshot recording in the same dogs.
Matthew M Abernathy, Derek D Best, Derek J Leishman

J Pharmacol Toxicol Methods· May 2025

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Characterization of Protein Binding on an Extracorporeal Membrane Oxygenation (ECMO) Circuit Following the Priming Procedure.
Tengyi Cai, Samantha J Emery-Corbin, Conor McCafferty, Suelyn Van Den Helm, Natasha Letunica, Derek Best

ASAIO J· April 2025

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Hemostatic Outcome Definitions in Pediatric Extracorporeal Membrane Oxygenation: Challenges in Cohorts From Rotterdam (2019-2023) and Melbourne (2016-2022).
Joppe Drop, Suelyn Van Den Helm, Natasha Letunica, Enno Wildschut, Matthijs de Hoog, Derek Best

Pediatr Crit Care Med· March 2025

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Demonstrating the statistical and pharmacological sensitivity of nonclinical QTc analysis using a dofetilide dose-response in nonhuman primates.
Derek J Leishman, David L Holdsworth, Derek D Best, Matthew M Abernathy, Brian M Roche

J Pharmacol Toxicol Methods· February 2025

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Immunofluorescence Protocol for Characterization of Platelet and Leukocyte Binding in Extracorporeal Membrane Oxygenation (ECMO) Circuits.
Tengyi Cai, Matthew Burton, Conor McCafferty, Suelyn Van Den Helm, Natasha Letunica, Derek Best

ASAIO J· January 2025

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Return to SENDer: The Submitted Electronic Data for Nonclinical Cardiovascular Studies is Not Facilitating Transparency, Translation or Innovation.
Matthew M Abernathy, Derek D Best, Derek J Leishman

Clin Pharmacol Ther· November 2024

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Comprehensive Characterization of Surface-Bound Proteins and Measurement of Fibrin Fiber Thickness on Extracorporeal Membrane Oxygenation Circuits Collected From Patients.
Tengyi Cai, Samantha J Emery-Corbin, Conor McCafferty, Suelyn Van Den Helm, Natasha Letunica, Derek Best

Pediatr Crit Care Med· November 2024

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A "one-step" approach to heart rate correction and statistical analysis applied to conscious dog QTc studies.
Derek D Best, Matthew M Abernathy, Derek J Leishman

Clin Transl Sci· October 2024

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Clinical Effects of Nitric Oxide Added to the Oxygenator of Children on Extracorporeal Membrane Oxygenation: Pre-Post Cohort Study.
Kevin C Pan, Siva P Namachivayam, Roberto Chiletti, Derek Best, Stephen Horton

ASAIO J· August 2024

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A comparison of the performance of contemporary, historical, and cross-lab controls in QTc assessment in conscious nonhuman primates.
Matthew M Abernathy, Derek D Best, Derek J Leishman

J Pharmacol Toxicol Methods· June 2024

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Comparing the sensitivity of cross-over and parallel study designs for QTc assessment: An analysis based on a single large study of moxifloxacin in 48 nonhuman primates.
Derek J Leishman, David L Holdsworth, Derek D Best, Brian M Roche

J Pharmacol Toxicol Methods· February 2024

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Factors XI and XII in extracorporeal membrane oxygenation: longitudinal profile in children.
Joppe Drop, Natasha Letunica, Suelyn Van Den Helm, C Heleen van Ommen, Enno Wildschut, Derek Best

Res Pract Thromb Haemost· November 2023

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Changes in von Willebrand Factor Multimers, Concentration, and Function During Pediatric Extracorporeal Membrane Oxygenation.
Suelyn Van Den Helm, Natasha Letunica, Rebecca Barton, Asami Weaver, Hui Ping Yaw, Derek Best

Pediatr Crit Care Med· April 2023

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Comparison of validity of standard nonclinical group size selection versus standard clinical group sizes for nonhuman primate QTc prolongation evaluation.
David Holdsworth, Derek D Best, Katarina Haist, Kyle O'Donohue, Anson Phillips

J Pharmacol Toxicol Methods· March 2023

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Platelet Phenotype and Function Changes With Increasing Duration of Extracorporeal Membrane Oxygenation.
Suelyn Van Den Helm, Hui Ping Yaw, Natasha Letunica, Rebecca Barton, Asami Weaver, Derek Best

Crit Care Med· August 2022

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Nonclinical safety assessment of epigenetic modulatory drugs: Current status and industry perspective.
Vincent L Reynolds, Paul Butler, Matthew M Abernathy, Laura Aschenbrenner, Derek D Best

Regul Toxicol Pharmacol· November 2020

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Extracorporeal membrane oxygenation for neonatal collapse caused by enterovirus myocarditis.
Gerard Cortina, Derek Best, Markus Deisenberg, Roberto Chiletti, Warwick Butt

Arch Dis Child Fetal Neonatal Ed· July 2018

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Extracorporeal membrane oxygenation for Kawasaki disease: two case reports and the Extracorporeal Life Support Organization experience 1999-2015.
Derek Best, Johnny Millar, Igor Kornilov, Yury Sinelnikov, Roberto Chiletti

Perfusion· October 2017

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Long-term survival after extracorporeal life support in children with neutropenic sepsis.
Sile Smith, Warwick Butt, Derek Best, Graeme MacLaren

Intensive Care Med· May 2016

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Safety of therapeutic hypothermia in children on veno-arterial extracorporeal membrane oxygenation after cardiac surgery.
Song Lou, Graeme MacLaren, John Clark, Eldho Paul, Derek Best

Cardiol Young· October 2015

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Safety of therapeutic hypothermia in children on veno-arterial extracorporeal membrane oxygenation after cardiac surgery - CORRIGENDUM.
Song Lou, Graeme MacLaren, Eldho Paul, Derek Best, Carmel Delzoppo

Cardiol Young· October 2015

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Prevalence of dysglycemia and association with outcomes in pediatric extracorporeal membrane oxygenation.
Song Lou, Graeme MacLaren, Eldho Paul, Derek Best, Carmel Delzoppo

Pediatr Crit Care Med· March 2015

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Hemofiltration is not associated with increased mortality in children receiving extracorporeal membrane oxygenation.
Song Lou, Graeme MacLaren, Eldho Paul, Derek Best, Carmel Delzoppo

Pediatr Crit Care Med· February 2015

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