Publications by authors named "Derek Bone"

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Effects of CT-388, a once-weekly signaling-biased dual GLP-1/GIP receptor agonist, on weight loss and glycemic control in preclinical models and participants with obesity.
Manu V Chakravarthy, Ruben Rodriguez, Anne Hergarden, Michael A Elliott, Juan P Frias, Derek Bone

Mol Metab· November 2025

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Biased agonism of GLP-1R and GIPR enhances glucose lowering and weight loss, with dual GLP-1R/GIPR biased agonism yielding greater efficacy.
Ruben Rodriguez, Anne Hergarden, Shyam Krishnan, Marikris Morales, Davina Lam, Derek Bone

Cell Rep Med· June 2025

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In vivo metabolic effects after acute activation of skeletal muscle G signaling.
Jaroslawna Meister, Derek B J Bone, Jonas R Knudsen, Luiz F Barella, Liu Liu

Mol Metab· January 2022

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Clenbuterol exerts antidiabetic activity through metabolic reprogramming of skeletal muscle cells.
Jaroslawna Meister, Derek B J Bone, Jonas R Knudsen, Luiz F Barella, Thomas J Velenosi

Nat Commun· January 2022

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Use of DREADD Technology to Identify Novel Targets for Antidiabetic Drugs.
Lei Wang, Lu Zhu, Jaroslawna Meister, Derek B J Bone, Sai P Pydi

Annu Rev Pharmacol Toxicol· January 2021

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Metabolic effects of skeletal muscle-specific deletion of beta-arrestin-1 and -2 in mice.
Jaroslawna Meister, Derek B J Bone, Grzegorz Godlewski, Ziyi Liu, Regina J Lee

PLoS Genet· October 2019

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Skeletal Muscle-Specific Activation of G Signaling Maintains Glucose Homeostasis.
Derek B J Bone, Jaroslawna Meister, Jonas R Knudsen, Diptadip Dattaroy, Amanda Cohen

Diabetes· June 2019

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DREADD technology reveals major impact of Gq signalling on cardiac electrophysiology.
Elisabeth Kaiser, Qinghai Tian, Michael Wagner, Monika Barth, Wenying Xian, Derek B J Bone

Cardiovasc Res· May 2019

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Changes in aortic reactivity associated with the loss of equilibrative nucleoside transporter 1 (ENT1) in mice.
K Arielle Best, Derek B Bone, Gonzalo Vilas, Robert Gros, James R Hammond

PLoS One· April 2019

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Oxidative stress modulates nucleobase transport in microvascular endothelial cells.
Derek B J Bone, Milica Antic, Gonzalo Vilas, James R Hammond

Microvasc Res· September 2014

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Loss of equilibrative nucleoside transporter 1 in mice leads to progressive ectopic mineralization of spinal tissues resembling diffuse idiopathic skeletal hyperostosis in humans.
Sumeeta Warraich, Derek B J Bone, Diana Quinonez, Hisataka Ii, Doo-Sup Choi

J Bone Miner Res· May 2013

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Nucleoside/nucleobase transport and metabolism by microvascular endothelial cells isolated from ENT1-/- mice.
Derek B J Bone, Doo-Sup Choi, Imogen R Coe, James R Hammond

Am J Physiol Heart Circ Physiol· September 2010

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Characterization of mENT1Delta11, a novel alternative splice variant of the mouse equilibrative nucleoside transporter 1.
Kevin R Robillard, Derek B J Bone, Jamie S Park, James R Hammond

Mol Pharmacol· July 2008

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Hypoxanthine uptake and release by equilibrative nucleoside transporter 2 (ENT2) of rat microvascular endothelial cells.
Kevin R Robillard, Derek B J Bone, James R Hammond

Microvasc Res· April 2008

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Nucleoside and nucleobase transporters of primary human cardiac microvascular endothelial cells: characterization of a novel nucleobase transporter.
Derek B J Bone, James R Hammond

Am J Physiol Heart Circ Physiol· December 2007

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Differential regulation of mouse equilibrative nucleoside transporter 1 (mENT1) splice variants by protein kinase CK2.
Derek B J Bone, Kevin R Robillard, Meaghan Stolk, James R Hammond

Mol Membr Biol· August 2007

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