Publications by authors named "Derek Sim"

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Total Synthesis, Configuration, and Antiplasmodium Activity of Fusarihexin D and E and Analogues.
Megan En Lee, Seetharamsing Balamkundu, Jiayong Liu, Donald Tay, Derek K Y Sim

J Nat Prod· June 2025

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Polymeric Anti-Antibiotic Microparticles to Prevent Antibiotic Resistance Evolution.
Roya Koshani, Shang-Lin Yeh, Zeming He, Naveen Narasimhalu, Landon G Vom Steeg, Derek G Sim

Small· May 2025

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Divergent modulation of activated protein C pleiotropic functions by antibodies that differ by a single amino acid.
Derek S Sim, Meenal Shukla, Cornell R Mallari, José A Fernández, Xiao Xu

Blood Adv· January 2025

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Intranasal SARS-CoV-2 RBD decorated nanoparticle vaccine enhances viral clearance in the Syrian hamster model.
Devanshi R Patel, Allen M Minns, Derek G Sim, Cassandra J Field, Abigail E Kerr

Microbiol Spectr· March 2024

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Rapid clearing CT-001 restored hemostasis in mice with coagulopathy induced by activated protein C.
Derek S Sim, Cornell R Mallari, Maxine Bauzon, Terry W Hermiston

J Trauma Acute Care Surg· February 2024

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CT-001, a novel fast-clearing factor VIIa, enhanced the hemostatic activity in postpartum samples.
Derek S Sim, Cornell R Mallari, Terry W Hermiston, Daekyeong Bae, Sul Lee

Blood Adv· January 2024

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Selective modulation of activated protein C activities by a nonactive site-targeting nanobody library.
Derek S Sim, Meenal Shukla, Cornell R Mallari, José A Fernández, Xiao Xu

Blood Adv· July 2023

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Divergent Evolutionary Pathways of Myxoma Virus in Australia: Virulence Phenotypes in Susceptible and Partially Resistant Rabbits Indicate Possible Selection for Transmissibility.
Peter J Kerr, Isabella M Cattadori, Derek Sim, June Liu, Edward C Holmes

J Virol· October 2022

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An orally administered drug prevents selection for antibiotic-resistant bacteria in the gut during daptomycin therapy.
Valerie J Morley, Derek G Sim, Aline Penkevich, Robert J Woods, Andrew F Read

Evol Med Public Health· August 2022

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CT-001 is a rapid clearing factor VIIa with enhanced clearance and hemostatic activity for the treatment of acute bleeding in non-hemophilia settings.
Derek S Sim, Cornell R Mallari, John M Teare, Maxine Bauzon, Terry W Hermiston

Thromb Res· July 2022

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Peptide nucleic acid-dependent artifact can lead to false-positive triplex gene editing signals.
Pui Yan Ho, Zhen Zhang, Mark E Hayes, Andrew Curd, Carla Dib, Derek S Sim

Proc Natl Acad Sci U S A· November 2021

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In vitro characterization of CT-001-a short-acting factor VIIa with enhanced prohemostatic activity.
Derek S Sim, Cornell R Mallari, John M Teare, Richard I Feldman, Maxine Bauzon

Res Pract Thromb Haemost· July 2021

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Transmission and Protection against Reinfection in the Ferret Model with the SARS-CoV-2 USA-WA1/2020 Reference Isolate.
Devanshi R Patel, Cassandra J Field, Kayla M Septer, Derek G Sim, Matthew J Jones

J Virol· June 2021

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An adjunctive therapy administered with an antibiotic prevents enrichment of antibiotic-resistant clones of a colonizing opportunistic pathogen.
Valerie J Morley, Clare L Kinnear, Derek G Sim, Samantha N Olson, Lindsey M Jackson

Elife· December 2020

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Targeted inhibition of activated protein C by a non-active-site inhibitory antibody to treat hemophilia.
Xiao-Yan Zhao, Andreas Wilmen, Dongli Wang, Xinquan Wang, Maxine Bauzon, Derek Sim

Nat Commun· June 2020

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Effect of drug dose and timing of treatment on the emergence of drug resistance in a malaria model.
Mónica M Acosta, Joshua T Bram, Derek Sim, Andrew F Read

Evol Med Public Health· June 2020

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The contribution of host cell-directed vs. parasite-directed immunity to the disease and dynamics of malaria infections.
Nina Wale, Matthew J Jones, Derek G Sim, Andrew F Read, Aaron A King

Proc Natl Acad Sci U S A· October 2019

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Blockade of placental growth factor reduces vaso-occlusive complications in murine models of sickle cell disease.
Jian-Ming Gu, Shujun Yuan, Derek Sim, Keith Abe, Perry Liu

Exp Hematol· April 2018

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Resource limitation prevents the emergence of drug resistance by intensifying within-host competition.
Nina Wale, Derek G Sim, Matthew J Jones, Rahel Salathe, Troy Day

Proc Natl Acad Sci U S A· December 2017

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Reverse Engineering Field Isolates of Myxoma Virus Demonstrates that Some Gene Disruptions or Losses of Function Do Not Explain Virulence Changes Observed in the Field.
June Liu, Isabella M Cattadori, Derek G Sim, John-Sebastian Eden, Edward C Holmes

J Virol· October 2017

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Next step in the ongoing arms race between myxoma virus and wild rabbits in Australia is a novel disease phenotype.
Peter J Kerr, Isabella M Cattadori, June Liu, Derek G Sim, Jeff W Dodds

Proc Natl Acad Sci U S A· August 2017

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A nutrient mediates intraspecific competition between rodent malaria parasites .
Nina Wale, Derek G Sim, Andrew F Read

Proc Biol Sci· July 2017

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Genomic and phenotypic characterization of myxoma virus from Great Britain reveals multiple evolutionary pathways distinct from those in Australia.
Peter J Kerr, Isabella M Cattadori, Matthew B Rogers, Adam Fitch, Adam Geber, Derek G Sim

PLoS Pathog· March 2017

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A Murine Model to Study Epilepsy and SUDEP Induced by Malaria Infection.
Paddy Ssentongo, Anna E Robuccio, Godfrey Thuku, Derek G Sim, Ali Nabi

Sci Rep· March 2017

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In Vivo Target Validation Using Biological Molecules in Drug Development.
Derek S Sim, Katalin Kauser

Handb Exp Pharmacol· June 2016

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