Publications by authors named "Devaraj Basavarajappa"

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Retinoid X receptor alpha overexpression protects retinal ganglion cells and modulates inflammatory response in experimental glaucoma.
Nitin Chitranshi, Devaraj Basavarajappa, Viswanthram Palanivel, Gabriella E Parrilla, Veer Gupta

Mol Ther· December 2025

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The Dynamic Roles of Repressor Element 1-Silencing Transcription Factor (REST): A Double-Edged Sword in Neural Health and Disease.
Taslima Akter Eva, Avinash Shenoy, Veer B Gupta, Viswanthram Palanivel, Akanksha Salkar, Devaraj Basavarajappa

Mol Neurobiol· November 2025

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Glial and immune dysregulation in glaucoma independent of retinal ganglion cell loss: a human post-mortem histopathology study.
Akanksha Salkar, Viswanthram Palanivel, Devaraj Basavarajappa, Mehdi Mirzaei, Angela Schulz

Acta Neuropathol Commun· June 2025

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Retinoid X receptor agonist 9CDHRA mitigates retinal ganglion cell apoptosis and neuroinflammation in a mouse model of glaucoma.
Devaraj Basavarajappa, Nitin Chitranshi, Seyed Shahab Oddin Mirshahvaladi, Veer B Gupta, Viswanthram Palanivel

FASEB J· March 2025

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RXR agonist, 9-cis-13,14-dihydroretinoic acid (9CDHRA), reduces damage and protects from demyelination in transsynaptic degeneration model.
Gabriella E Parrilla, Roshana Vander Wall, Nitin Chitranshi, Devaraj Basavarajappa, Vivek Gupta

Neuroscience· November 2024

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VEP Latency Delay Reflects Demyelination Beyond the Optic Nerve in the Cuprizone Model.
Roshana Vander Wall, Devaraj Basavarajappa, Viswanthram Palanivel, Samridhi Sharma, Vivek Gupta

Invest Ophthalmol Vis Sci· November 2024

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Glial Cell Activation and Immune Responses in Glaucoma: A Systematic Review of Human Postmortem Studies of the Retina and Optic Nerve.
Akanksha Salkar, Roshana Vander Wall, Devaraj Basavarajappa, Nitin Chitranshi, Gabriella E Parilla

Aging Dis· October 2024

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Brain-Derived Neurotrophic Factor Val66Met is Associated with Variation in Cortical Structure in Healthy Aging Subjects.
Ting Shen, Samran Sheriff, Yuyi You, Jiyang Jiang, Angela Schulz, Devaraj Basavarajappa

Aging Dis· October 2024

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Mechanisms of Transsynaptic Degeneration in the Aging Brain.
Roshana Vander Wall, Devaraj Basavarajappa, Alexander Klistoner, Stuart Graham, Yuyi You

Aging Dis· October 2024

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Neuropeptide Y receptor activation preserves inner retinal integrity through PI3K/Akt signaling in a glaucoma mouse model.
Viswanthram Palanivel, Vivek Gupta, Nitin Chitranshi, Ole Tietz, Roshana Vander Wall, Devaraj Basavarajappa

PNAS Nexus· August 2024

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Tau modulation through AAV9 therapy augments Akt/Erk survival signalling in glaucoma mitigating the retinal degenerative phenotype.
Kanishka Pushpitha Maha Thananthirige, Nitin Chitranshi, Devaraj Basavarajappa, Rashi Rajput, Mojdeh Abbasi

Acta Neuropathol Commun· June 2024

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The role of myelin in neurodegeneration: implications for drug targets and neuroprotection strategies.
Gabriella E Parrilla, Vivek Gupta, Roshana Vander Wall, Akanksha Salkar, Devaraj Basavarajappa

Rev Neurosci· April 2024

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Quantitative Proteomics Reveal Region-Specific Alterations in Neuroserpin-Deficient Mouse Brain and Retina: Insights into Serpini1 Function.
Shahab Mirshahvaladi, Nitin Chitranshi, Ardeshir Amirkhani, Rashi Rajput, Devaraj Basavarajappa

Proteomes· March 2024

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Anti-inflammatory Effects of Siponimod in a Mouse Model of Excitotoxicity-Induced Retinal Injury.
Devaraj Basavarajappa, Vivek Gupta, Nitin Chitranshi, Deepa Viswanathan, Veer Gupta

Mol Neurobiol· December 2023

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Signalling pathways and cell death mechanisms in glaucoma: Insights into the molecular pathophysiology.
Devaraj Basavarajappa, Caridad Galindo-Romero, Vivek Gupta, Marta Agudo-Barriuso, Veer B Gupta

Mol Aspects Med· December 2023

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Neuroserpin gene therapy inhibits retinal ganglion cell apoptosis and promotes functional preservation in glaucoma.
Nitin Chitranshi, Rashi Rajput, Angela Godinez, Kanishka Pushpitha, Mehdi Mirzaei, Devaraj Basavarajappa

Mol Ther· July 2023

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Siponimod exerts neuroprotective effects on the retina and higher visual pathway through neuronal S1PR1 in experimental glaucoma.
Devaraj Basavarajappa, Vivek Gupta, Nitin Chitranshi, Roshana Vander Wall, Rashi Rajput

Neural Regen Res· April 2023

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S1PR1 signaling attenuates apoptosis of retinal ganglion cells via modulation of cJun/Bim cascade and Bad phosphorylation in a mouse model of glaucoma.
Devaraj Basavarajappa, Vivek Gupta, Roshana Vander Wall, Veer Gupta, Nitin Chitranshi

FASEB J· January 2023

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Neuroprotective Effects of Neuropeptide Y on Human Neuroblastoma SH-SY5Y Cells in Glutamate Excitotoxicity and ER Stress Conditions.
Viswanthram Palanivel, Vivek Gupta, Seyed Shahab Oddin Mirshahvaladi, Samridhi Sharma, Veer Gupta, Devaraj Basavarajappa

Cells· November 2022

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Fingolimod effects on the brain are mediated through biochemical modulation of bioenergetics, autophagy, and neuroinflammatory networks.
Mehdi Mirzaei, Morteza Abyadeh, Anita J Turner, Roshana Vander Wall, Joel M Chick, Devaraj Basavarajappa

Proteomics· October 2022

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Retinoid X Receptor: Cellular and Biochemical Roles of Nuclear Receptor with a Focus on Neuropathological Involvement.
Samridhi Sharma, Ting Shen, Nitin Chitranshi, Veer Gupta, Devaraj Basavarajappa

Mol Neurobiol· April 2022

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Correction to: Retinoid X Receptor: Cellular and Biochemical Roles of Nuclear Receptor with a Focus on Neuropathological Involvement.
Samridhi Sharma, Ting Shen, Nitin Chitranshi, Veer Gupta, Devaraj Basavarajappa

Mol Neurobiol· April 2022

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Trans-synaptic degeneration in the visual pathway: Neural connectivity, pathophysiology, and clinical implications in neurodegenerative disorders.
Samridhi Sharma, Nitin Chitranshi, Roshana Vander Wall, Devaraj Basavarajappa, Vivek Gupta

Surv Ophthalmol· March 2022

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Neuroserpin, a crucial regulator for axogenesis, synaptic modelling and cell-cell interactions in the pathophysiology of neurological disease.
Angela Godinez, Rashi Rajput, Nitin Chitranshi, Veer Gupta, Devaraj Basavarajappa

Cell Mol Life Sci· March 2022

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Identification of Novel Cathepsin B Inhibitors with Implications in Alzheimer's Disease: Computational Refining and Biochemical Evaluation.
Nitin Chitranshi, Ashutosh Kumar, Samran Sheriff, Veer Gupta, Angela Godinez, Devaraj Basavarajappa

Cells· July 2021

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