Publications by authors named "Devin Tesar"

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Exploring How Antibody Format Drives Clearance from the Brain.
Kelly Schwinghamer, Brian M Kopec, Ebehiremen Ayewoh, Xun Tao, Shraddha Sadekar, Devin B Tesar

Mol Pharm· September 2024

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Selective Uptake of Macromolecules to the Brain in Microfluidics and Animal Models Using the HAVN1 Peptide as a Blood-Brain Barrier Modulator.
Kelly Schwinghamer, Stacey Line, Devin B Tesar, Donald W Miller, Alavattam Sreedhara

Mol Pharm· April 2024

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A Review of Protein- and Peptide-Based Chemical Conjugates: Past, Present, and Future.
Emily Holz, Martine Darwish, Devin B Tesar, Whitney Shatz-Binder

Pharmaceutics· February 2023

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Insights into ultra-low affinity lipase-antibody noncovalent complex binding mechanisms.
Elizabeth Sara Hecht, Shrenik Mehta, Aaron T Wecksler, Ben Aguilar, Nathaniel Swanson, Devin Tesar

MAbs· October 2022

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Generation of a Porcine Antibody Fab Fragment Using Protein Engineering to Facilitate the Evaluation of Ocular Sustained Delivery Technology.
Robert F Kelley, Devin B Tesar, Yue Wang, Nicholas J Agard, Patrick G Holder

Mol Pharm· May 2022

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Retinal and Lens Degeneration in New Zealand White Rabbits Administered Intravitreal TSG-6 Link Domain-Rabbit FAb Fusion Proteins.
Steven T Laing, Nardos Tassew, Devin Tesar, Yue Wang, Susan R Crowell

Toxicol Pathol· April 2021

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An Approach to Bioactivity Assessment for Critical Quality Attribute Identification Based on Antibody-Antigen Complex Structure.
Xuan Gao, Weiru Wang, Devin Tesar, Bingchuan Wei, John Eschelbach

J Pharm Sci· April 2021

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Protein conjugates and fusion proteins as ocular therapeutics.
Shrenik C Mehta, Robert F Kelley, Devin B Tesar

Drug Discov Today· August 2019

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An FcRn- dependent transcytosis assay as a screening tool for predictive assessment of nonspecific clearance of antibody therapeutics in humans.
Shan Chung, Van Nguyen, Yuwen Linda Lin, Julien Lafrance-Vanasse, Suzie J Scales, Devin Tesar

MAbs· July 2019

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Protein engineering to increase the potential of a therapeutic antibody Fab for long-acting delivery to the eye.
Devin Tesar, Jacob Luoma, Emily A Wyatt, Catherine Shi, Whitney Shatz

MAbs· July 2018

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Evaluating the Use of Antibody Variable Region (Fv) Charge as a Risk Assessment Tool for Predicting Typical Cynomolgus Monkey Pharmacokinetics.
Daniela Bumbaca Yadav, Vikas K Sharma, Charles Andrew Boswell, Isidro Hotzel, Devin Tesar

J Biol Chem· December 2015

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Modular protein expression by RNA trans-splicing enables flexible expression of antibody formats in mammalian cells from a dual-host phage display vector.
Yonglei Shang, Devin Tesar, Isidro Hötzel

Protein Eng Des Sel· October 2015

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Framework selection can influence pharmacokinetics of a humanized therapeutic antibody through differences in molecule charge.
Bing Li, Devin Tesar, C Andrew Boswell, Hendry S Cahaya, Anne Wong

MAbs· August 2015

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Quantitative cumulative biodistribution of antibodies in mice: effect of modulating binding affinity to the neonatal Fc receptor.
Victor Yip, Enzo Palma, Devin B Tesar, Eduardo E Mundo, Daniela Bumbaca

MAbs· May 2015

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Minipig as a potential translatable model for monoclonal antibody pharmacokinetics after intravenous and subcutaneous administration.
Yanan Zheng, Devin B Tesar, Lisa Benincosa, Herbert Birnböck, C Andrew Boswell

MAbs· February 2015

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A dual host vector for Fab phage display and expression of native IgG in mammalian cells.
Devin Tesar, Isidro Hötzel

Protein Eng Des Sel· October 2013

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Intracellular neutralization of viral infection in polarized epithelial cells by neonatal Fc receptor (FcRn)-mediated IgG transport.
Yu Bai, Lilin Ye, Devin B Tesar, Haichen Song, Deming Zhao

Proc Natl Acad Sci U S A· November 2011

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Charge variants in IgG1: Isolation, characterization, in vitro binding properties and pharmacokinetics in rats.
Leslie A Khawli, Sirj Goswami, Ryan Hutchinson, Zephania W Kwong, Jihong Yang, Devin Tesar

MAbs· March 2011

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Effects of charge on antibody tissue distribution and pharmacokinetics.
C Andrew Boswell, Devin B Tesar, Kiran Mukhyala, Frank-Peter Theil, Paul J Fielder

Bioconjug Chem· December 2010

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Comparison of FcRn- and pIgR-mediated transport in MDCK cells by fluorescence confocal microscopy.
Galina V Jerdeva, Devin B Tesar, Kathryn E Huey-Tubman, Mark S Ladinsky, Scott E Fraser

Traffic· September 2010

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An intracellular traffic jam: Fc receptor-mediated transport of immunoglobulin G.
Devin B Tesar, Pamela J Björkman

Curr Opin Struct Biol· April 2010

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The chicken yolk sac IgY receptor, a mammalian mannose receptor family member, transcytoses IgY across polarized epithelial cells.
Devin B Tesar, Evelyn J Cheung, Pamela J Bjorkman

Mol Biol Cell· April 2008

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A freeze substitution fixation-based gold enlarging technique for EM studies of endocytosed Nanogold-labeled molecules.
Wanzhong He, Christine Kivork, Suman Machinani, Mary K Morphew, Anna M Gail, Devin B Tesar

J Struct Biol· October 2007

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Ligand valency affects transcytosis, recycling and intracellular trafficking mediated by the neonatal Fc receptor.
Devin B Tesar, Noreen E Tiangco, Pamela J Bjorkman

Traffic· September 2006

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