Publications by authors named "Dexin Deng"

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Novel Isoalantolactone-Based Derivatives as Potent NLRP3 Inflammasome Inhibitors: Design, Synthesis, and Biological Characterization.
Min Zhao, Neng Ye, Ling Liu, Rui-Jia Zhang, Na Li, De-Xin Deng

J Med Chem· May 2024

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Discovery of 4-amino-1,6-dihydro-7H-pyrrolo[2,3-d]pyridazin-7-one derivatives as potential receptor-interacting serine/threonine-protein kinase 1 (RIPK1) inhibitors.
Chufeng Zhang, Yulian Chen, Yong Li, Na Shi, Yaxin Teng, Dexin Deng

Eur J Med Chem· February 2024

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Discovery, Optimization, and Evaluation of Potent and Selective DNA-PK Inhibitors in Combination with Chemotherapy or Radiotherapy for the Treatment of Malignancies.
Kongjun Liu, Xue Yuan, Tao Yang, Dexin Deng, Yong Chen

J Med Chem· January 2024

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Discovery of pyrimidine-5-carboxamide derivatives as novel salt-inducible kinases (SIKs) inhibitors for inflammatory bowel disease (IBD) treatment.
Xiaoying Cai, Lun Wang, Yuyao Yi, Dexin Deng, Mingsong Shi

Eur J Med Chem· August 2023

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Discovery and Evaluation of 3-Quinoxalin Urea Derivatives as Potent, Selective, and Orally Available ATM Inhibitors Combined with Chemotherapy for the Treatment of Cancer via Goal-Oriented Molecule Generation and Virtual Screening.
Dexin Deng, Yingxue Yang, Yurong Zou, Kongjun Liu, Chufeng Zhang

J Med Chem· July 2023

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Design, synthesis and biological evaluation of purine-based derivatives as novel JAK2/BRD4(BD2) dual target inhibitors.
Yong Guo, Yurong Zou, Yong Chen, Dexin Deng, Zihao Zhang

Bioorg Chem· March 2023

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A bibliometric analysis of 16,826 triple-negative breast cancer publications using multiple machine learning algorithms: Progress in the past 17 years.
Kangtao Wang, Chanjuan Zheng, Lian Xue, Dexin Deng, Liang Zeng, Xiyun Deng

Front Med (Lausanne)· February 2023

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Discovery of Potent and Selective Receptor-Interacting Serine/Threonine Protein Kinase 2 (RIPK2) Inhibitors for the Treatment of Inflammatory Bowel Diseases (IBDs).
Xue Yuan, Yong Chen, Minghai Tang, Yuhan Wei, Mingsong Shi, Dexin Deng

J Med Chem· July 2022

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Discovery, Optimization, and Evaluation of Potent and Selective PI3Kδ-γ Dual Inhibitors for the Treatment of B-cell Malignancies.
Kongjun Liu, Wei Zheng, Yong Chen, Minghai Tang, Dan Li, Dexin Deng, Xiandeng Li

J Med Chem· July 2022

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Synthesis and biological evaluation of 6-(pyrimidin-4-yl)-1H-pyrazolo[4,3-b]pyridine derivatives as novel dual FLT3/CDK4 inhibitors.
Xiandeng Li, Tao Yang, Mengshi Hu, Yingxue Yang, Minghai Tang, Dexin Deng

Bioorg Chem· April 2022

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Degrading FLT3-ITD protein by proteolysis targeting chimera (PROTAC).
Yong Chen, Xue Yuan, Minghai Tang, Mingsong Shi, Tao Yang, Dexin Deng

Bioorg Chem· February 2022

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Discovery, Optimization, and Evaluation of Quinazolinone Derivatives with Novel Linkers as Orally Efficacious Phosphoinositide-3-Kinase Delta Inhibitors for Treatment of Inflammatory Diseases.
Kongjun Liu, Dan Li, Wei Zheng, Mingsong Shi, Yong Chen, Dexin Deng

J Med Chem· July 2021

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Discovery of 3-(4-(2-((1-Indol-5-yl)amino)-5-fluoropyrimidin-4-yl)-1-pyrazol-1-yl)propanenitrile Derivatives as Selective TYK2 Inhibitors for the Treatment of Inflammatory Bowel Disease.
Chufeng Zhang, Wenyan Qi, Yong Li, Minghai Tang, Tao Yang, Dexin Deng

J Med Chem· February 2021

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Synthesis and evaluation of new compounds bearing 3-(4-aminopiperidin-1-yl)methyl magnolol scaffold as anticancer agents for the treatment of non-small cell lung cancer via targeting autophagy.
Min Zhao, Yun-Hua Zheng, Qi-Yuan Zhao, Wei Zheng, Jian-Hong Yang, De-Xin Deng

Eur J Med Chem· January 2021

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Design, synthesis and discovery of 2(1H)-quinolone derivatives for the treatment of pulmonary fibrosis through inhibition of TGF-β/smad dependent and independent pathway.
Linlin Xue, Dexin Deng, Shoujun Zheng, Minghai Tang, Zhuang Yang

Eur J Med Chem· July 2020

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Synthesis and discovery of new compounds bearing coumarin scaffold for the treatment of pulmonary fibrosis.
Dexin Deng, Heying Pei, Tingxuan Lan, Jiali Zhu, Minghai Tang

Eur J Med Chem· January 2020

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Selective repression of retinoic acid target genes by RIP140 during induced tumor cell differentiation of pluripotent human embryonal carcinoma cells.
Kelly C Heim, Kristina A White, Dexin Deng, Craig R Tomlinson, Jason H Moore

Mol Cancer· September 2007

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Limiting effects of RIP140 in estrogen signaling: potential mediation of anti-estrogenic effects of retinoic acid.
Kristina A White, Mark M Yore, Dexin Deng, Michael J Spinella

J Biol Chem· March 2005

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