Publications by authors named "Dezai Dai"

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AQP4-knockout aggravation of isoprenaline-induced myocardial injury is mediated by p66Shc and endoplasmic reticulum stress.
Yusi Cheng, Jie Chao, Dezai Dai, Yin Dai, Dongdong Zhu

Clin Exp Pharmacol Physiol· November 2017

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Exogenous hydrogen sulphide ameliorates diabetic cardiomyopathy in rats by reversing disordered calcium-handling system in sarcoplasmic reticulum.
Yu-Si Cheng, De-Zai Dai, Yin Dai, Dong-Dong Zhu, Bi-Cheng Liu

J Pharm Pharmacol· March 2016

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Argirein alleviates stress-induced and diabetic hypogonadism in rats via normalizing testis endothelin receptor A and connexin 43.
Ming Xu, Chen Hu, Hussein-hamed Khan, Fang-hong Shi, Xiao-dong Cong, Yin Dai, De-zai Dai

Acta Pharmacol Sin· February 2016

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David Triggle: Research collaborations and scientific exchanges with the China Pharmaceutical University, Nanjing, China.
De-Zai Dai

Biochem Pharmacol· November 2015

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CPUY11018, an azimilide derivative, ameliorates isoproterenol-induced cardiac insufficiency through relieving dysfunctional mitochondria and endoplasmic reticulum.
Meng Li, Yi-Qun Tang, Rong-Hui Du, Fang-Hong Shi, Humed Khan Hussein, De-Zai Dai, Yin Dai

J Pharm Pharmacol· August 2015

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Isoproterenol induced stressful reactions in the brain are characterized by inflammation due to activation of NADPH oxidase and ER stress: attenuated by Apocynin, Rehmannia complex and Triterpene acids.
Guo-Long Mo, Ying Li, Rong-Hui Du, De-Zai Dai, Xiao-Dong Cong, Yin Dai

Neurochem Res· April 2014

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Hypoxia/oxidative stress alters the pharmacokinetics of CPU86017-RS through mitochondrial dysfunction and NADPH oxidase activation.
Jie Gao, Xuan-sheng Ding, Yu-mao Zhang, De-zai Dai, Mei Liu, Yin Dai

Acta Pharmacol Sin· December 2013

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AQP4 KO exacerbating renal dysfunction is mediated by endoplasmic reticulum stress and p66Shc and is attenuated by apocynin and endothelin antagonist CPU0213.
Yu-Si Cheng, De-Zai Dai, Yin Dai

Eur J Pharmacol· December 2013

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Hypoxia alters pharmacokinetics of argirein because of mitochondrial dysfunction that is alleviated by apocynin.
Yu-Mao Zhang, Feng Yu, De-Zai Dai, Jie Gao, Xiao-Dong Cong, Yin Dai

J Pharm Pharmacol· September 2013

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Male hypogonadism induced by high fat diet and low dose streptozotocin is mediated by activated endoplasmic reticulum stress and IκBβ and attenuated by argirein and valsartan.
Gui-Lai Liu, Yu-Mao Zhang, De-Zai Dai, Ming-Jian Ding, Xiao-Dong Cong, Yin Dai

Eur J Pharmacol· August 2013

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Hepatosteatosis and hepatic insulin resistance are blunted by argirein, an anti-inflammatory agent, through normalizing endoplasmic reticulum stress and apoptosis in diabetic liver.
Fang-Hong Shi, You Wu, De-Zai Dai, Xiao-Dong Cong, Yu-Mao Zhang, Yin Dai

J Pharm Pharmacol· June 2013

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Apocynin and raisanberine alleviate intermittent hypoxia induced abnormal StAR and 3β-HSD and low testosterone by suppressing endoplasmic reticulum stress and activated p66Shc in rat testes.
Guo-Lin Zhang, De-Zai Dai, Can Zhang, Yin Dai

Reprod Toxicol· April 2013

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Argirein alleviates corpus cavernosum dysfunction by suppressing pro-inflammatory factors p66Shc and ER stress chaperone Bip in diabetic rats.
Yu-Si Cheng, Xiao-Dong Cong, De-Zai Dai, Yun Zhang, Yin Dai

J Pharm Pharmacol· January 2013

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Pharmacokinetic behavior of argirein, derived from rhein, is characterized as slow release and prolonged T₁/₂ of rhein in rats.
Xiao-Dong Cong, Peng-Rong Fu, De-Zai Dai, Yun Zhang, Yin Dai

Eur J Pharm Sci· August 2012

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Activation of AQP4, p66Shc and endoplasmic reticulum stress is involved in inflammation by carrageenan and is suppressed by argirein, a derivative of rhein.
Xiao-Dong Cong, You Wu, De-Zai Dai, Ming-Jian Ding, Yun Zhang, Yin Dai

J Pharm Pharmacol· August 2012

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ER stress, p66shc, and p-Akt/Akt mediate adjuvant-induced inflammation, which is blunted by argirein, a supermolecule and rhein in rats.
Xiao-Dong Cong, Ming-Jian Ding, De-Zai Dai, You Wu, Yun Zhang, Yin Dai

Inflammation· June 2012

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Raisanberine protected pulmonary arterial rings and cardiac myocytes of rats against hypoxia injury by suppressing NADPH oxidase and calcium influx.
Jie Gao, Yi-qun Tang, De-zai Dai, Yu-si Cheng, Guo-lin Zhang, Yin Dai

Acta Pharmacol Sin· May 2012

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CPU86017-RS attenuate hypoxia-induced testicular dysfunction in mice by normalizing androgen biosynthesis genes and pro-inflammatory cytokines.
Guo-lin Zhang, Feng Yu, De-zai Dai, Yu-si Cheng, Can Zhang, Yin Dai

Acta Pharmacol Sin· April 2012

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Comparison of sildenafil with strontium fructose diphosphate in improving erectile dysfunction against upregulated cavernosal NADPH oxidase, protein kinase Cε, and endothelin system in diabetic rats.
Ming Xu, Yi-Qun Tang, De-Zai Dai, Yu-Feng Zheng, Yu-Si Cheng, Yin Dai

J Pharm Pharmacol· February 2012

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AQP4 knockout mice manifest abnormal expressions of calcium handling proteins possibly due to exacerbating pro-inflammatory factors in the heart.
Yu-Si Cheng, Yi-Qun Tang, De-Zai Dai, Yin Dai

Biochem Pharmacol· January 2012

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Endoplasmic reticulum stress mediating downregulated StAR and 3-beta-HSD and low plasma testosterone caused by hypoxia is attenuated by CPU86017-RS and nifedipine.
Gui-Lai Liu, Feng Yu, De-Zai Dai, Guo-Lin Zhang, Can Zhang, Yin Dai

J Biomed Sci· January 2012

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Sildenafil improves diabetic vascular activity through suppressing endothelin receptor A, iNOS and NADPH oxidase which is comparable with the endothelin receptor antagonist CPU0213 in STZ-injected rats.
Lu Luo, De-Zai Dai, Yu-Si Cheng, Qi Zhang, Wen-Jun Yuan, Yin Dai

J Pharm Pharmacol· July 2011

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Sildenafil and FDP-Sr attenuate diabetic cardiomyopathy by suppressing abnormal expression of myocardial CASQ2, FKBP12.6, and SERCA2a in rats.
Yu-si Cheng, De-zai Dai, Hui Ji, Qi Zhang, Yin Dai

Acta Pharmacol Sin· April 2011

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Argirein alleviates diabetic nephropathy through attenuating NADPH oxidase, Cx43, and PERK in renal tissue.
C Hu, X D Cong, De-Zai Dai, Y Zhang, G L Zhang, Y Dai

Naunyn Schmiedebergs Arch Pharmacol· March 2011

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Isoproterenol-induced FKBP12.6/12 downregulation is modulated by ETA and ETB receptors and reversed by argirhein, a derivative of rhein.
Guo-lin Zhang, De-zai Dai, Tao Xi, Xiao-dong Cong, Yun Zhang, Yin Dai

Acta Pharmacol Sin· February 2011

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