Publications by authors named "Diederik W D Kuster"

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Systemic administration of analgesic buprenorphine, but not carprofen, affects cardiomyocyte contractility in rodents.
Inez Duursma, Valentijn Jansen, Nicole Zaat, Tyler J Kirby, Jolanda van der Velden, Diederik W D Kuster

J Mol Cell Cardiol Plus· December 2025

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Hypercontractility and Oxidative Stress Drive Creatine Kinase Dysfunction in Hypertrophic Cardiomyopathy.
Anton Xu, David Weissman, Katharina J Ermer, Edoardo Bertero, Jan M Federspiel, Diederik W D Kuster

Circulation· December 2025

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Heterogeneous Dysregulation of Myosin Super-Relaxation and Energetics in Hypertrophic Cardiomyopathy.
Julien Ochala, Miao Feng, Qian Wang, Chahida Chaami, Edgar E Nollet, Diederik W D Kuster

Circ Heart Fail· September 2025

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Generation of induced pluripotent stem cell lines from five individuals from two families carrying a pathogenic Dutch MYBPC3 founder variant with variable degrees of hypertrophic cardiomyopathy.
Floor W van den Dolder, Vincent A J Warnaar, Yeszamin L Onderwater, Annette F Baas, Diederik W D Kuster

Stem Cell Res· August 2025

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Glycogen synthase kinase-3 inhibition and insulin enhance proliferation and inhibit maturation of human iPSC-derived cardiomyocytes via TCF and FOXO signaling.
Qianliang Yuan, Devin Verbueken, Rafeeh Dinani, Rosa Kim, Eric Schoger, Diederik W D Kuster

Stem Cell Reports· January 2025

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Integrating Clinical Phenotype With Multiomics Analyses of Human Cardiac Tissue Unveils Divergent Metabolic Remodeling in Genotype-Positive and Genotype-Negative Patients With Hypertrophic Cardiomyopathy.
Edgar E Nollet, Maike Schuldt, Vasco Sequeira, Aleksandra Binek, Thang V Pham, Diederik W D Kuster

Circ Genom Precis Med· June 2024

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Endothelial identity not found - Beyond passage 38, commercial cardiac microvascular endothelial cells do not express CD31 and VE-cadherin.
Sarah Hilderink, Jolanda van der Velden, Diederik W D Kuster

J Mol Cell Cardiol Plus· June 2024

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Translating myosin-binding protein C and titin abnormalities to whole-heart function using a novel calcium-contraction coupling model.
Theo Arts, Aurore Lyon, Tammo Delhaas, Diederik W D Kuster, Jolanda van der Velden

J Mol Cell Cardiol· May 2024

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Hypertrophic cardiomyopathy dysfunction mimicked in human engineered heart tissue and improved by sodium-glucose cotransporter 2 inhibitors.
Paul J M Wijnker, Rafeeh Dinani, Nico C van der Laan, Sila Algül, Bjorn C Knollmann, Diederik W D Kuster

Cardiovasc Res· March 2024

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Western diet triggers cardiac dysfunction in heterozygous -targeted knock-in mice: A two-hit model of hypertrophic cardiomyopathy.
Edgar E Nollet, Sila Algül, Max Goebel, Saskia Schlossarek, Nicole N van der Wel, Diederik W D Kuster

J Mol Cell Cardiol Plus· December 2023

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Characterization of heterozygous and homozygous mouse models with the most common hypertrophic cardiomyopathy mutation MYBPC3 in the Netherlands.
Sarah Hilderink, Maike Schuldt, Max Goebel, Valentijn J Jansen, Emmy Manders, Diederik W D Kuster

J Mol Cell Cardiol· December 2023

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DWORF Extends Life Span in a PLN-R14del Cardiomyopathy Mouse Model by Reducing Abnormal Sarcoplasmic Reticulum Clusters.
Nienke M Stege, Tim R Eijgenraam, Vivian Oliveira Nunes Teixeira, Anna M Feringa, Elisabeth M Schouten, Diederik W D Kuster

Circ Res· December 2023

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Geranylgeranylacetone reduces cardiomyocyte stiffness and attenuates diastolic dysfunction in a rat model of cardiometabolic syndrome.
Mark T Waddingham, Vasco Sequeira, Diederik W D Kuster, Elisa Dal Canto, M Louis Handoko

Physiol Rep· November 2023

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The microtubule signature in cardiac disease: etiology, disease stage, and age dependency.
Sıla Algül, Larissa M Dorsch, Oana Sorop, Aryan Vink, Michelle Michels, Diederik W D Kuster

J Comp Physiol B· October 2023

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EGFR/IGF1R Signaling Modulates Relaxation in Hypertrophic Cardiomyopathy.
Sila Algül, Maike Schuldt, Emmy Manders, Valentijn Jansen, Saskia Schlossarek, Diederik W D Kuster

Circ Res· August 2023

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The RNA-binding protein QKI governs a muscle-specific alternative splicing program that shapes the contractile function of cardiomyocytes.
Pablo Montañés-Agudo, Simona Aufiero, Eva N Schepers, Ingeborg van der Made, Lucia Cócera-Ortega, Diederik W D Kuster

Cardiovasc Res· May 2023

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Real-Time Measurements of Calcium and Contractility Parameters in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes.
Rafeeh Dinani, Emmy Manders, Michiel Helmes, Lili Wang, Bjorn Knollmann, Diederik W D Kuster

J Vis Exp· May 2023

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Mitochondrial dysfunction in human hypertrophic cardiomyopathy is linked to cardiomyocyte architecture disruption and corrected by improving NADH-driven mitochondrial respiration.
Edgar E Nollet, Inez Duursma, Anastasiya Rozenbaum, Moritz Eggelbusch, Rob C I Wüst, Diederik W D Kuster

Eur Heart J· April 2023

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COVID19 Impairs Cardiac Function via Endothelial H19 and IL6 Signaling.
Rio P Juni, Philippa G Phelp, Diewertje I Bink, Veerle Kremer, Anke S van Bergen, Diederik W D Kuster

Circ Res· March 2023

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Animal models and animal-free innovations for cardiovascular research: current status and routes to be explored. Consensus document of the ESC Working Group on Myocardial Function and the ESC Working Group on Cellular Biology of the Heart.
Jolanda van der Velden, Folkert W Asselbergs, Jeroen Bakkers, Sandor Batkai, Luc Bertrand, Diederik W D Kuster

Cardiovasc Res· December 2022

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Equal force generation potential of trabecular and compact wall ventricular cardiomyocytes.
Jaeike W Faber, Rob C I Wüst, Inge Dierx, Janneke A Hummelink, Diederik W D Kuster

iScience· November 2022

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Optical control of the β-adrenergic receptor with opto-prop-2: A -active azobenzene analog of propranolol.
Reggie Bosma, Nicola C Dijon, Yang Zheng, Hannes Schihada, Niels J Hauwert, Diederik W D Kuster

iScience· September 2022

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Characterization of cardiac metabolism in iPSC-derived cardiomyocytes: lessons from maturation and disease modeling.
Sofija Vučković, Rafeeh Dinani, Edgar E Nollet, Diederik W D Kuster, Jan Willem Buikema

Stem Cell Res Ther· July 2022

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Single-cell transcriptomics provides insights into hypertrophic cardiomyopathy.
Martijn Wehrens, Anne E de Leeuw, Maya Wright-Clark, Joep E C Eding, Cornelis J Boogerd, Diederik W D Kuster

Cell Rep· May 2022

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Beneficial Effects of Cardiomyopathy-Associated Genetic Variants on Physical Performance: A Hypothesis-Generating Scoping Review.
Sjoerd M Verwijs, Yigal M Pinto, Diederik W D Kuster, Jolanda van der Velden, Jacqueline Limpens

Cardiology· February 2022

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