Publications by authors named "Digantkumar Chapla"

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Mucin-type -glycans regulate proteoglycan stability and chondrocyte maturation.
Xiaolin Dong, Sydney Bedillion, Kaleigh E Gosnell, Peng Zhao, Amrita Basu, Digantkumar Chapla

bioRxiv· December 2025

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Biochemical and structural characterization of glycosyltransferase family 61 proteins reveal a key determinant of sugar donor specificity.
Hsin-Tzu Wang, Jose Henrique Pereira, Andy M DeGiovanni, Pradeep Kumar Prabhakar, Digantkumar Chapla

bioRxiv· July 2025

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Siglec-targeted liposomes to identify sialoglycans present on fungal pathogens.
Suresh Ambati, Quanita J Choudhury, Jesse Ann Peter, Kelley W Moremen, Digantkumar Gopaldas Chapla

Antimicrob Agents Chemother· April 2025

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Charge matters: how flanking substrate charge modulates O-glycan Core elongation.
Collin J Ballard, Matthew R Smutny, Lam D Chau, Collin K Wong, Haley M Aharoni, Digantkumar G Chapla

Glycobiology· March 2025

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Enforced E-selectin ligand installation enhances homing and efficacy of adoptively transferred T cells.
Yingqin Hou, Jinfeng Ye, Ke Qin, Leigh-Ann Cui, Shereen Chung, Digantkumar Gopaldas Chapla

bioRxiv· January 2025

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Chemoenzymatic Synthesis of Keratan Sulfate Oligosaccharides Using UDP-Galactose-6-aldehyde To Control Sulfation at Galactosides.
Yunfei Wu, Gerlof P Bosman, Gaël M Vos, Elif Uslu, Digantkumar Chapla

Org Lett· October 2024

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Chemoenzymatic Synthesis of Sulfated -Glycans Recognized by Siglecs and Other Glycan-Binding Proteins.
Kun Huang, Eleanor E Bashian, Guanghui Zong, Corwin M Nycholat, Ryan McBride, Digantkumar G Chapla

JACS Au· August 2024

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Integrated chemoenzymatic synthesis of a comprehensive sulfated ganglioside glycan library to decipher functional sulfoglycomics and sialoglycomics.
Zhuojia Xu, Yating Liu, Jialin Liu, Wenjing Ma, Zhumin Zhang, Digantkumar G Chapla

Nat Chem· June 2024

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A Biomimetic Synthetic Strategy Can Provide Keratan Sulfate I and II Oligosaccharides with Diverse Fucosylation and Sulfation Patterns.
Yunfei Wu, Gerlof P Bosman, Digantkumar Chapla, Chin Huang, Kelley W Moremen

J Am Chem Soc· April 2024

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Glycosyltransferase 8 domain-containing protein 1 (GLT8D1) is a UDP-dependent galactosyltransferase.
João B Vicente, Ana Catarina L Guerreiro, Beatriz Felgueiras, Digantkumar Chapla, Daniel Tehrani

Sci Rep· December 2023

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Exploiting Substrate Specificities of 6--Sulfotransferases to Enzymatically Synthesize Keratan Sulfate Oligosaccharides.
Yunfei Wu, Gaël M Vos, Chin Huang, Digantkumar Chapla, Anne L M Kimpel

JACS Au· November 2023

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Chemoenzymatic Tagging of Tn/TF/STF Antigens in Living Systems.
Yi Yang, Mingkuan Chen, Mengyao Wu, Senlian Hong, Bing Gao, Digantkumar Gopaldas Chapla

Isr J Chem· October 2023

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Structural basis for Lewis antigen synthesis by the α1,3-fucosyltransferase FUT9.
Renuka Kadirvelraj, Bhargavi M Boruah, Shuo Wang, Digantkumar Chapla, Chin Huang

Nat Chem Biol· August 2023

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The Plasminogen-Apple-Nematode (PAN) domain suppresses JA/ET defense pathways in plants.
Kuntal De, Debjani Pal, Carly M Shanks, Timothy B Yates, Kai Feng, Digantkumar Chapla

bioRxiv· June 2023

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Structural basis for heparan sulfate co-polymerase action by the EXT1-2 complex.
Hua Li, Digantkumar Chapla, Robert A Amos, Annapoorani Ramiah, Kelley W Moremen

Nat Chem Biol· May 2023

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Structural and biochemical insight into a modular β-1,4-galactan synthase in plants.
Pradeep Kumar Prabhakar, Jose Henrique Pereira, Rahil Taujale, Wanchen Shao, Vivek S Bharadwaj, Digantkumar Chapla

Nat Plants· March 2023

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Extracellular sialyltransferase st6gal1 in breast tumor cell growth and invasiveness.
Nitai C Hait, Aparna Maiti, Rongrong Wu, Valerie L Andersen, Chang-Chieh Hsu, Digantkumar G Chapla

Cancer Gene Ther· November 2022

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Site-selective sulfation of N-glycans by human GlcNAc-6-O-sulfotransferase 1 (CHST2) and chemoenzymatic synthesis of sulfated antibody glycoforms.
Kun Huang, Chao Li, Guanghui Zong, Sunaina Kiran Prabhu, Digantkumar G Chapla

Bioorg Chem· November 2022

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Sequential in vitro enzymatic N-glycoprotein modification reveals site-specific rates of glycoenzyme processing.
Trevor M Adams, Peng Zhao, Digantkumar Chapla, Kelley W Moremen, Lance Wells

J Biol Chem· October 2022

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A universal glycoenzyme biosynthesis pipeline that enables efficient cell-free remodeling of glycans.
Thapakorn Jaroentomeechai, Yong Hyun Kwon, Yiwen Liu, Olivia Young, Ruchika Bhawal, Digantkumar G Chapla

Nat Commun· October 2022

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Extracellular ST6GAL1 regulates monocyte-macrophage development and survival.
Michael E Rusiniak, Patrick R Punch, Nitai C Hait, Aparna Maiti, Robert T Burns, Digantkumar Chapla

Glycobiology· July 2022

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Human Intelectin-1 Promotes Cellular Attachment and Neutrophil Killing of Streptococcus pneumoniae in a Serotype-Dependent Manner.
Silke Andresen, Kayla Fantone, Digantkumar Chapla, Balázs Rada, Kelley W Moremen

Infect Immun· May 2022

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Elucidating Human Milk Oligosaccharide biosynthetic genes through network-based multi-omics integration.
Benjamin P Kellman, Anne Richelle, Jeong-Yeh Yang, Digantkumar Chapla, Austin W T Chiang

Nat Commun· May 2022

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Integrated Chemoenzymatic Approach to Streamline the Assembly of Complex Glycopeptides in the Liquid Phase.
Wenjing Ma, Yaqi Deng, Zhuojia Xu, Xingbang Liu, Digantkumar G Chapla

J Am Chem Soc· May 2022

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Glycan remodeled erythrocytes facilitate antigenic characterization of recent A/H3N2 influenza viruses.
Frederik Broszeit, Rosanne J van Beek, Luca Unione, Theo M Bestebroer, Digantkumar Chapla

Nat Commun· September 2021

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