Publications by authors named "Dimitri Shcherbakov"

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Signs of Premature Kidney Aging in Mice With Error-Prone Protein Synthesis.
Laurine Lang, Rocío Fuente, José Manuel López, Eva-María Pastor-Arroyo, Petra Seebeck, Dimitri Shcherbakov

FASEB J· June 2025

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Translational error in mice increases with ageing in an organ-dependent manner.
Erik C Böttger, Harshitha Santhosh Kumar, Adrian Steiner, Emmanuel Sotirakis, Kader Thiam, Dimitri Shcherbakov

Nat Commun· February 2025

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Bacterial genome-wide association study substantiates papGII of Escherichia coli as a major risk factor for urosepsis.
Aline Cuénod, Jessica Agnetti, Helena M B Seth-Smith, Tim Roloff, Denise Wälchli, Dimitri Shcherbakov

Genome Med· October 2023

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Error-prone protein synthesis recapitulates early symptoms of Alzheimer disease in aging mice.
Margarita Brilkova, Martina Nigri, Harshitha Santhosh Kumar, James Moore, Matilde Mantovani, Dimitri Shcherbakov

Cell Rep· September 2022

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Optimization of the antimicrobial peptide Bac7 by deep mutational scanning.
Philipp Koch, Steven Schmitt, Alexander Heynisch, Anja Gumpinger, Irene Wüthrich, Dimitri Shcherbakov

BMC Biol· May 2022

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Phenotype of Mrps5-Associated Phylogenetic Polymorphisms Is Intimately Linked to Mitoribosomal Misreading.
Reda Juskeviciene, Ann-Kristina Fritz, Margarita Brilkova, Rashid Akbergenov, Karen Schmitt, Dimitri Shcherbakov

Int J Mol Sci· April 2022

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Premature aging in mice with error-prone protein synthesis.
Dimitri Shcherbakov, Martina Nigri, Rashid Akbergenov, Margarita Brilkova, Matilde Mantovani

Sci Adv· March 2022

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ER-misfolded proteins become sequestered with mitochondria and impair mitochondrial function.
Adrián Cortés Sanchón, Harshitha Santhosh Kumar, Matilde Mantovani, Ivan Osinnii, José María Mateos, Dimitri Shcherbakov

Commun Biol· December 2021

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Synthesis, antibacterial action, and ribosome inhibition of deoxyspectinomycins.
Suresh Dharuman, Laura A Wilt, Jiuyu Liu, Stephanie M Reeve, Carl W Thompson, Dimitri Shcherbakov

J Antibiot (Tokyo)· June 2021

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Random errors in protein synthesis activate an age-dependent program of muscle atrophy in mice.
James Moore, Rashid Akbergenov, Martina Nigri, Patricia Isnard-Petit, Amandine Grimm, Dimitri Shcherbakov

Commun Biol· June 2021

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Mitochondrial Mistranslation in Brain Provokes a Metabolic Response Which Mitigates the Age-Associated Decline in Mitochondrial Gene Expression.
Dimitri Shcherbakov, Reda Juskeviciene, Adrián Cortés Sanchón, Margarita Brilkova, Hubert Rehrauer

Int J Mol Sci· March 2021

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Mitochondrial misreading in skeletal muscle accelerates metabolic aging and confers lipid accumulation and increased inflammation.
Dimitri Shcherbakov, Stefan Duscha, Reda Juskeviciene, Lisa M Restelli, Stephan Frank

RNA· February 2021

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Stereocontrolled Synthesis of (-)-Bactobolin A.
Petra Vojáčková, Lucyna Michalska, Marek Nečas, Dimitri Shcherbakov, Erik C Böttger

J Am Chem Soc· April 2020

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Apralogs: Apramycin 5--Glycosides and Ethers with Improved Antibacterial Activity and Ribosomal Selectivity and Reduced Susceptibility to the Aminoacyltranserferase (3)-IV Resistance Determinant.
Jonathan C K Quirke, Parasuraman Rajasekaran, Vikram A Sarpe, Amr Sonousi, Ivan Osinnii, Dimitri Shcherbakov

J Am Chem Soc· January 2020

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Synthesis, ribosomal selectivity, and antibacterial activity of netilmicin 4'-derivatives.
Amr Sonousi, Dimitri Shcherbakov, Andrea Vasella, Erik C Böttger, David Crich

Medchemcomm· June 2019

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Design, Multigram Synthesis, and in Vitro and in Vivo Evaluation of Propylamycin: A Semisynthetic 4,5-Deoxystreptamine Class Aminoglycoside for the Treatment of Drug-Resistant Enterobacteriaceae and Other Gram-Negative Pathogens.
Takahiko Matsushita, Girish C Sati, Nuwan Kondasinghe, Michael G Pirrone, Takayuki Kato, Dimitri Shcherbakov

J Am Chem Soc· March 2019

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Mutant MRPS5 affects mitoribosomal accuracy and confers stress-related behavioral alterations.
Rashid Akbergenov, Stefan Duscha, Ann-Kristina Fritz, Reda Juskeviciene, Naoki Oishi, Dimitri Shcherbakov

EMBO Rep· November 2018

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Structure-Based Design and Synthesis of Apramycin-Paromomycin Analogues: Importance of the Configuration at the 6'-Position and Differences between the 6'-Amino and Hydroxy Series.
Appi Reddy Mandhapati, Guanyu Yang, Takayuki Kato, Dimitri Shcherbakov, Sven N Hobbie

J Am Chem Soc· October 2017

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N6', N6''', and O4' Modifications to Neomycin Affect Ribosomal Selectivity without Compromising Antibacterial Activity.
Girish C Sati, Dimitri Shcherbakov, Sven N Hobbie, Andrea Vasella, Erik C Böttger

ACS Infect Dis· May 2017

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Influence of 4'-O-Glycoside Constitution and Configuration on Ribosomal Selectivity of Paromomycin.
Takahiko Matsushita, Weiwei Chen, Reda Juskeviciene, Youjin Teo, Dimitri Shcherbakov

J Am Chem Soc· June 2015

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Aminomethyl spectinomycins as therapeutics for drug-resistant respiratory tract and sexually transmitted bacterial infections.
David F Bruhn, Samanthi L Waidyarachchi, Dora B Madhura, Dimitri Shcherbakov, Zhong Zheng

Sci Transl Med· May 2015

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Importance of the 6'-hydroxy group and its configuration for apramycin activity.
Appi Reddy Mandhapati, Dimitri Shcherbakov, Stefan Duscha, Andrea Vasella, Erik C Böttger

ChemMedChem· September 2014

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Identification and evaluation of improved 4'-O-(alkyl) 4,5-disubstituted 2-deoxystreptamines as next-generation aminoglycoside antibiotics.
Stefan Duscha, Heithem Boukari, Dimitri Shcherbakov, Sumantha Salian, Sandrina Silva

mBio· September 2014

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Phylogenetic sequence variations in bacterial rRNA affect species-specific susceptibility to drugs targeting protein synthesis.
Subramanian Akshay, Mihai Bertea, Sven N Hobbie, Björn Oettinghaus, Dimitri Shcherbakov

Antimicrob Agents Chemother· September 2011

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