Publications by authors named "Dirk A Kleinjan"

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Lampreys, the jawless vertebrates, contain three Pax6 genes with distinct expression in eye, brain and pancreas.
Vydianathan Ravi, Shipra Bhatia, Prashant Shingate, Boon-Hui Tay, Byrappa Venkatesh, Dirk A Kleinjan

Sci Rep· December 2019

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Functional characteristics of novel pancreatic Pax6 regulatory elements.
Adam Buckle, Ryu-Suke Nozawa, Dirk A Kleinjan, Nick Gilbert

Hum Mol Genet· October 2018

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Drug-tunable multidimensional synthetic gene control using inducible degron-tagged dCas9 effectors.
Dirk A Kleinjan, Caroline Wardrope, Si Nga Sou, Susan J Rosser

Nat Commun· October 2017

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Regulation of SPRY3 by X chromosome and PAR2-linked promoters in an autism susceptibility region.
Zhenfei Ning, Andrew S McLellan, Melanie Ball, Freda Wynne, Cora O'Neill, Dirk A Kleinjan

Hum Mol Genet· December 2015

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Remotely acting SMCHD1 gene regulatory elements: in silico prediction and identification of potential regulatory variants in patients with FSHD.
Mary B Mayes, Taniesha Morgan, Jincy Winston, Daniel S Buxton, Mihir Anant Kamat, Dirk A Kleinjan

Hum Genomics· October 2015

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Regulation of SPRY3 by X chromosome and PAR2-linked promoters in an autism susceptibility region.
Zhenfei Ning, Andrew S McLellan, Melanie Ball, Freda Wynne, Cora O'Neill, Dirk A Kleinjan

Hum Mol Genet· September 2015

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Functional assessment of disease-associated regulatory variants in vivo using a versatile dual colour transgenesis strategy in zebrafish.
Shipra Bhatia, Christopher T Gordon, Robert G Foster, Lucie Melin, Véronique Abadie, Dirk A Kleinjan

PLoS Genet· June 2015

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Identification of novel craniofacial regulatory domains located far upstream of SOX9 and disrupted in Pierre Robin sequence.
Christopher T Gordon, Catia Attanasio, Shipra Bhatia, Sabina Benko, Morad Ansari, Dirk A Kleinjan

Hum Mutat· August 2014

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Disruption of long-range gene regulation in human genetic disease: a kaleidoscope of general principles, diverse mechanisms and unique phenotypic consequences.
Shipra Bhatia, Dirk A Kleinjan

Hum Genet· July 2014

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Identification of genomic regions regulating Pax6 expression in embryonic forebrain using YAC reporter transgenic mouse lines.
Da Mi, Yu-Ting Huang, Dirk A Kleinjan, John O Mason, David J Price

PLoS One· June 2014

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Disruption of SATB2 or its long-range cis-regulation by SOX9 causes a syndromic form of Pierre Robin sequence.
Jacqueline K Rainger, Shipra Bhatia, Hemant Bengani, Philippe Gautier, Joe Rainger, Dirk A Kleinjan

Hum Mol Genet· May 2014

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A survey of ancient conserved non-coding elements in the PAX6 locus reveals a landscape of interdigitated cis-regulatory archipelagos.
Shipra Bhatia, Jack Monahan, Vydianathan Ravi, Philippe Gautier, Emma Murdoch, Dirk A Kleinjan

Dev Biol· March 2014

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Genomic profiling of type-1 adult diabetic and aged normoglycemic mouse liver.
Flávia G Ghiraldini, André B Silveira, Dirk A Kleinjan, Nick Gilbert, Maria Luiza S Mello

BMC Endocr Disord· March 2014

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Disruption of autoregulatory feedback by a mutation in a remote, ultraconserved PAX6 enhancer causes aniridia.
Shipra Bhatia, Hemant Bengani, Margaret Fish, Alison Brown, Maria Teresa Divizia, Dirk A Kleinjan

Am J Hum Genet· December 2013

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The developmental regulator Pax6 is essential for maintenance of islet cell function in the adult mouse pancreas.
Alan W Hart, Sebastien Mella, Jacek Mendrychowski, Veronica van Heyningen, Dirk A Kleinjan

PLoS One· July 2013

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Sequencing of Pax6 loci from the elephant shark reveals a family of Pax6 genes in vertebrate genomes, forged by ancient duplications and divergences.
Vydianathan Ravi, Shipra Bhatia, Philippe Gautier, Felix Loosli, Boon-Hui Tay, Dirk A Kleinjan

PLoS Genet· May 2013

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DNaseI hypersensitivity and ultraconservation reveal novel, interdependent long-range enhancers at the complex Pax6 cis-regulatory region.
David J McBride, Adam Buckle, Veronica van Heyningen, Dirk A Kleinjan

PLoS One· April 2012

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Discovery and assessment of conserved Pax6 target genes and enhancers.
Pedro Coutinho, Sofia Pavlou, Shipra Bhatia, Kevin J Chalmers, Dirk A Kleinjan

Genome Res· August 2011

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Effects of elevated Pax6 expression and genetic background on mouse eye development.
Simon A Chanas, J Martin Collinson, Thaya Ramaesh, Natalie Dorà, Dirk A Kleinjan

Invest Ophthalmol Vis Sci· September 2009

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Mosaic analysis of stem cell function and wound healing in the mouse corneal epithelium.
Richard L Mort, Thaya Ramaesh, Dirk A Kleinjan, Steven D Morley, John D West

BMC Dev Biol· January 2009

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Long-range gene control and genetic disease.
Dirk A Kleinjan, Laura A Lettice

Adv Genet· November 2008

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Cited2 is required for the proper formation of the hyaloid vasculature and for lens morphogenesis.
Yu Chen, Yong-qiu Doughman, Shi Gu, Andrew Jarrell, Shin-ichi Aota, Dirk A Kleinjan

Development· September 2008

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Subfunctionalization of duplicated zebrafish pax6 genes by cis-regulatory divergence.
Dirk A Kleinjan, Ruth M Bancewicz, Philippe Gautier, Ralf Dahm, Helia B Schonthaler

PLoS Genet· February 2008

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Controlled overexpression of Pax6 in vivo negatively autoregulates the Pax6 locus, causing cell-autonomous defects of late cortical progenitor proliferation with little effect on cortical arealization.
Martine Manuel, Petrina A Georgala, Catherine B Carr, Simon Chanas, Dirk A Kleinjan

Development· February 2007

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Long-range downstream enhancers are essential for Pax6 expression.
Dirk A Kleinjan, Anne Seawright, Sebastien Mella, Catherine B Carr, David A Tyas

Dev Biol· November 2006

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