Publications by authors named "Dirk Spitzer"

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Trametinib Thwarts Activation of Survival Pathways Induced by Pro-ferroptotic Drug Conjugate ACXT-3102 Resulting in Enhanced Pancreatic Cancer Cell Death.
Kumar S Bishnupuri, Kenneth F Newcomer, Qingqing Gong, Rony Takchi, Li Ye, Dirk Spitzer

Mol Cancer Ther· December 2025

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Cytotoxic sigma-2 ligands trigger cancer cell death via cholesterol-induced-ER-stress.
Rony Takchi, Bethany C Prudner, Qingqing Gong, Takaomi Hagi, Kenneth F Newcomer, Dirk Spitzer

Cell Death Dis· May 2024

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The novel drug candidate S2/IAPinh improves survival in models of pancreatic and ovarian cancer.
Takaomi Hagi, Suwanna Vangveravong, Rony Takchi, Qingqing Gong, S Peter Goedegebuure, Dirk Spitzer

Sci Rep· March 2024

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Malic Enzyme 1 Absence in Synovial Sarcoma Shifts Antioxidant System Dependence and Increases Sensitivity to Ferroptosis Induction with ACXT-3102.
Caitlyn B Brashears, Bethany C Prudner, Richa Rathore, Katharine E Caldwell, Carina A Dehner, Dirk Spitzer

Clin Cancer Res· August 2022

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The targeted SMAC mimetic SW IV-134 augments platinum-based chemotherapy in pre-clinical models of ovarian cancer.
Pratibha S Binder, Yassar M Hashim, James Cripe, Tommy Buchanan, Abigail Zamorano, Dirk Spitzer

BMC Cancer· March 2022

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Preclinical Evaluation of an Engineered Single-Chain Fragment Variable-Fragment Crystallizable Targeting Human CD44.
Philipp Diebolder, Cedric Mpoy, Jalen Scott, Truc T Huynh, Ryan Fields, Dirk Spitzer

J Nucl Med· January 2021

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Adenovirus platform enhances transduction efficiency of human mesenchymal stem cells: An opportunity for cellular carriers of targeted TRAIL-based TR3 biologics in ovarian cancer.
Lindsay M Kuroki, Xingjian Jin, Igor P Dmitriev, Elena A Kashentseva, Matthew A Powell, Dirk Spitzer

PLoS One· January 2018

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Multifunctional thiosemicarbazones and deconstructed analogues as a strategy to study the involvement of metal chelation, Sigma-2 (σ) receptor and P-gp protein in the cytotoxic action: In vitro and in vivo activity in pancreatic tumors.
Maria Laura Pati, Mauro Niso, Dirk Spitzer, Francesco Berardi, Marialessandra Contino

Eur J Med Chem· January 2018

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Sigma-2 receptor agonist derivatives of 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) induce cell death via mitochondrial superoxide production and caspase activation in pancreatic cancer.
Maria Laura Pati, John R Hornick, Mauro Niso, Francesco Berardi, Dirk Spitzer

BMC Cancer· January 2017

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The Targeted SMAC Mimetic SW IV-134 is a strong enhancer of standard chemotherapy in pancreatic cancer.
Yassar M Hashim, Suwanna Vangveravong, Narendra V Sankpal, Pratibha S Binder, Jingxia Liu, Dirk Spitzer

J Exp Clin Cancer Res· January 2017

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Conjugation to the sigma-2 ligand SV119 overcomes uptake blockade and converts dm-Erastin into a potent pancreatic cancer therapeutic.
Kerri A Ohman, Yassar M Hashim, Suwanna Vangveravong, Timothy M Nywening, Darren R Cullinan, Dirk Spitzer

Oncotarget· June 2016

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Mesothelin's minimal MUC16 binding moiety converts TR3 into a potent cancer therapeutic via hierarchical binding events at the plasma membrane.
Yang Su, Katharina Tatzel, Xuejun Wang, Brian Belt, Pratibha Binder, Dirk Spitzer

Oncotarget· May 2016

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Erratum: Membrane-proximal TRAIL species are incapable of inducing short circuit apoptosis signaling: Implications for drug development and basic cytokine biology.
Katharina Tatzel, Lindsay Kuroki, Igor Dmitriev, Elena Kashentseva, David T Curiel, Dirk Spitzer

Sci Rep· May 2016

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Membrane-proximal TRAIL species are incapable of inducing short circuit apoptosis signaling: Implications for drug development and basic cytokine biology.
Katharina Tatzel, Lindsay Kuroki, Igor Dmitriev, Elena Kashentseva, David T Curiel, Dirk Spitzer

Sci Rep· March 2016

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Incorporation of porcine adenovirus 4 fiber protein enhances infectivity of adenovirus vector on dendritic cells: implications for immune-mediated cancer therapy.
Ivy Wilkinson-Ryan, Julius Kim, Sojung Kim, Ferhat Ak, Lindzy Dodson, Dirk Spitzer

PLoS One· January 2016

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Targeted pancreatic cancer therapy with the small molecule drug conjugate SW IV-134.
Yassar M Hashim, Dirk Spitzer, Suwanna Vangveravong, Mary C Hornick, Gunjal Garg

Mol Oncol· July 2014

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Synergistic effects of concurrent blockade of PI3K and MEK pathways in pancreatic cancer preclinical models.
Hua Zhong, Cesar Sanchez, Dirk Spitzer, Stacy Plambeck-Suess, Jesse Gibbs

PLoS One· June 2014

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Conjugation to a SMAC mimetic potentiates sigma-2 ligand induced tumor cell death in ovarian cancer.
Gunjal Garg, Suwanna Vangveravong, Chenbo Zeng, Lynne Collins, Mary Hornick, Dirk Spitzer

Mol Cancer· March 2014

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Novel treatment option for MUC16-positive malignancies with the targeted TRAIL-based fusion protein Meso-TR3.
Gunjal Garg, Jesse Gibbs, Brian Belt, Matthew A Powell, David G Mutch, Dirk Spitzer

BMC Cancer· January 2014

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A dual function of NKG2D ligands in NK-cell activation.
Elizabeth E Cheney, Erica L Wise, Jack D Bui, Robert D Schreiber, Leonidas N Carayannopoulos, Dirk Spitzer

Eur J Immunol· September 2012

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Therapeutic targeting of pancreatic cancer utilizing sigma-2 ligands.
John R Hornick, Dirk Spitzer, Peter Goedegebuure, Robert H Mach, William G Hawkins

Surgery· September 2012

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Targeting recombinant thrombomodulin fusion protein to red blood cells provides multifaceted thromboprophylaxis.
Sergei Zaitsev, M Anna Kowalska, Michael Neyman, Ronald Carnemolla, Samira Tliba, Dirk Spitzer

Blood· May 2012

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Lysosomal membrane permeabilization is an early event in Sigma-2 receptor ligand mediated cell death in pancreatic cancer.
John R Hornick, Suwanna Vangveravong, Dirk Spitzer, Carmen Abate, Francesco Berardi

J Exp Clin Cancer Res· May 2012

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Use of multifunctional sigma-2 receptor ligand conjugates to trigger cancer-selective cell death signaling.
Dirk Spitzer, Peter O Simon, Hiroyuki Kashiwagi, Jinbin Xu, Chenbo Zeng

Cancer Res· January 2012

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Fluorescent derivatives of σ receptor ligand 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) as a tool for uptake and cellular localization studies in pancreatic tumor cells.
Carmen Abate, John R Hornick, Dirk Spitzer, William G Hawkins, Mauro Niso

J Med Chem· August 2011

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