Publications by authors named "Dominic Cosgrove"

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Ototoxic impacts of adipose-derived extracts on a murine auditory cell line: molecular insights from proteomic analyses.
Appolinaire A Olou, Wesley Tom, Gary Krzyzanowski, Chao Jiang, Dinesh Chandel, Dominic Cosgrove

Int J Obes (Lond)· December 2025

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Alpha-dystroglycan receptor signaling likely influences basement membrane laminin α2 mediated pathology in the stria vascularis of Alport mice.
Daniel T Meehan, Julia Brockhouse, Katherine Connell, Jacob Madison, Michael Anne Gratton, Dominic Cosgrove

Hear Res· October 2025

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Ramipril therapy in integrin α1-null, autosomal recessive Alport mice triples lifespan: mechanistic clues from RNA-seq analysis.
Jacob Madison, Kevin Wilhelm, Daniel T Meehan, Michael Anne Gratton, Denise Vosik, Dominic Cosgrove

J Pathol· March 2024

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Dual inhibition of the endothelin and angiotensin receptor ameliorates renal and inner ear pathologies in Alport mice.
Dominic Cosgrove, Michael Anne Gratton, Jacob Madison, Denise Vosik, Gina Samuelson

J Pathol· July 2023

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The usherin mutation c.2299delG leads to its mislocalization and disrupts interactions with whirlin and VLGR1.
Lars Tebbe, Maggie L Mwoyosvi, Ryan Crane, Mustafa S Makia, Mashal Kakakhel, Dominic Cosgrove

Nat Commun· February 2023

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Glomerular basement membrane deposition of collagen α1(III) in Alport glomeruli by mesangial filopodia injures podocytes via aberrant signaling through DDR1 and integrin α2β1.
Jacob Madison, Kevin Wilhelm, Daniel T Meehan, Duane Delimont, Gina Samuelson, Dominic Cosgrove

J Pathol· September 2022

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Molecular and Cellular Mechanisms Underlying the Initiation and Progression of Alport Glomerular Pathology.
Dominic Cosgrove, Jacob Madison

Front Med (Lausanne)· February 2022

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RNA-seq analysis of gene expression profiles in isolated stria vascularis from wild-type and Alport mice reveals key pathways underling Alport strial pathogenesis.
Brianna Dufek, Daniel T Meehan, Duane Delimont, Kevin Wilhelm, Gina Samuelson, Dominic Cosgrove

PLoS One· October 2020

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Pericyte abnormalities precede strial capillary basement membrane thickening in Alport mice.
Brianna Dufek, Daniel T Meehan, Duane Delimont, Gina Samuelson, Jacob Madison, Dominic Cosgrove

Hear Res· May 2020

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Human α1 type IV collagen NC1 domain exhibits distinct antiangiogenic activity mediated by α1β1 integrin.
Akulapalli Sudhakar, Pia Nyberg, Venkateshwar G Keshamouni, Arjuna P Mannam, Jian Li, Dominic Cosgrove

J Clin Invest· January 2020

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Lysyl oxidase like-2 contributes to renal fibrosis in Col4α3/Alport mice.
Dominic Cosgrove, Brianna Dufek, Daniel T Meehan, Duane Delimont, Michael Hartnett

Kidney Int· August 2018

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X-Linked Alport Dogs Demonstrate Mesangial Filopodial Invasion of the Capillary Tuft as an Early Event in Glomerular Damage.
Sabrina D Clark, Mary B Nabity, Rachel E Cianciolo, Brianna Dufek, Dominic Cosgrove

PLoS One· July 2017

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Collagen IV diseases: A focus on the glomerular basement membrane in Alport syndrome.
Dominic Cosgrove, Shiguang Liu

Matrix Biol· January 2017

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Endothelin-1 mediated induction of extracellular matrix genes in strial marginal cells underlies strial pathology in Alport mice.
Daniel T Meehan, Duane Delimont, Brianna Dufek, Marisa Zallocchi, Grady Phillips, Dominic Cosgrove

Hear Res· November 2016

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Endothelin A receptor activation on mesangial cells initiates Alport glomerular disease.
Brianna Dufek, Daniel T Meehan, Duane Delimont, Linda Cheung, Michael Anne Gratton, Dominic Cosgrove

Kidney Int· August 2016

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Laminin α2-mediated focal adhesion kinase activation triggers Alport glomerular pathogenesis.
Duane Delimont, Brianna M Dufek, Daniel T Meehan, Marisa Zallocchi, Michael Anne Gratton, Dominic Cosgrove

PLoS One· January 2015

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EIAV-based retinal gene therapy in the shaker1 mouse model for usher syndrome type 1B: development of UshStat.
Marisa Zallocchi, Katie Binley, Yatish Lad, Scott Ellis, Peter Widdowson, Dominic Cosgrove

PLoS One· December 2014

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Photoreceptors in whirler mice show defective transducin translocation and are susceptible to short-term light/dark changes-induced degeneration.
Mei Tian, Weimin Wang, Duane Delimont, Linda Cheung, Marisa Zallocchi, Dominic Cosgrove

Exp Eye Res· January 2014

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Usher protein functions in hair cells and photoreceptors.
Dominic Cosgrove, Marisa Zallocchi

Int J Biochem Cell Biol· January 2014

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Light-induced translocation of RGS9-1 and Gβ5L in mouse rod photoreceptors.
Mei Tian, Marisa Zallocchi, Weimin Wang, Ching-Kang Chen, Krzysztof Palczewski, Dominic Cosgrove

PLoS One· October 2013

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α1β1 integrin/Rac1-dependent mesangial invasion of glomerular capillaries in Alport syndrome.
Marisa Zallocchi, Brianna M Johnson, Daniel T Meehan, Duane Delimont, Dominic Cosgrove

Am J Pathol· October 2013

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Regulated vesicular trafficking of specific PCDH15 and VLGR1 variants in auditory hair cells.
Marisa Zallocchi, Duane Delimont, Daniel T Meehan, Dominic Cosgrove

J Neurosci· October 2012

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Glomerular pathology in Alport syndrome: a molecular perspective.
Dominic Cosgrove

Pediatr Nephrol· June 2012

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Role for a novel Usher protein complex in hair cell synaptic maturation.
Marisa Zallocchi, Daniel T Meehan, Duane Delimont, Joseph Rutledge, Michael Anne Gratton, Dominic Cosgrove

PLoS One· June 2012

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Moderate light-induced degeneration of rod photoreceptors with delayed transducin translocation in shaker1 mice.
You-Wei Peng, Marisa Zallocchi, Wei-Min Wang, Duane Delimont, Dominic Cosgrove

Invest Ophthalmol Vis Sci· August 2011

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