Publications by authors named "Donald A Winkelmann"

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A myosin hypertrophic cardiomyopathy mutation disrupts the super-relaxed state and boosts contractility by enhanced actin attachment.
Robert C Cail, Bipasha Barua, Faviolla A Báez-Cruz, Donald A Winkelmann, Yale E Goldman

Proc Natl Acad Sci U S A· December 2025

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S2Tag, a novel affinity tag for the capture and immobilization of coiled-coil proteins: Application to the study of human β-cardiac myosin.
Bipasha Barua, Robert C Cail, Yale E Goldman, E Michael Ostap, Donald A Winkelmann

J Biol Chem· November 2025

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A myosin hypertrophic cardiomyopathy mutation disrupts the super-relaxed state and boosts contractility by enhanced actin attachment.
Robert C Cail, Bipasha Barua, Faviolla A Báez-Cruz, Donald A Winkelmann, Yale E Goldman

bioRxiv· July 2025

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Swinging lever mechanism of myosin directly shown by time-resolved cryo-EM.
David P Klebl, Sean N McMillan, Cristina Risi, Eva Forgacs, Betty Virok, Donald A Winkelmann

Nature· June 2025

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Dynamics of β-cardiac myosin between the super-relaxed and disordered-relaxed states.
Robert C Cail, Faviolla A Báez-Cruz, Donald A Winkelmann, Yale E Goldman, E Michael Ostap

J Biol Chem· May 2025

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S2Tag, a novel affinity tag for the capture and immobilization of coiled-coil proteins: application to the study of human β-cardiac myosin.
Bipasha Barua, Robert C Cail, Yale E Goldman, E Michael Ostap, Donald A Winkelmann

bioRxiv· May 2025

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Mavacamten inhibits myosin activity by stabilising the myosin interacting-heads motif and stalling motor force generation.
Sean N McMillan, Jaime R T Pitts, Bipasha Barua, Donald A Winkelmann, Charlotte A Scarff

bioRxiv· February 2025

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Dynamics of β-cardiac myosin between the super-relaxed and disordered-relaxed states.
Robert C Cail, Faviolla A Baez-Cruz, Donald A Winkelmann, Yale E Goldman, E Michael Ostap

bioRxiv· December 2024

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Myosin with hypertrophic cardiac mutation R712L has a decreased working stroke which is rescued by omecamtiv mecarbil.
Aaron Snoberger, Bipasha Barua, Jennifer L Atherton, Henry Shuman, Eva Forgacs, Donald A Winkelmann

Elife· February 2021

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Single molecule mechanics resolves the earliest events in force generation by cardiac myosin.
Michael S Woody, Donald A Winkelmann, Marco Capitanio, E Michael Ostap, Yale E Goldman

Elife· September 2019

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Positive cardiac inotrope omecamtiv mecarbil activates muscle despite suppressing the myosin working stroke.
Michael S Woody, Michael J Greenberg, Bipasha Barua, Donald A Winkelmann, Yale E Goldman

Nat Commun· September 2018

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Structural basis for drug-induced allosteric changes to human β-cardiac myosin motor activity.
Donald A Winkelmann, Eva Forgacs, Matthew T Miller, Ann M Stock

Nat Commun· August 2015

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Omecamtiv Mecarbil modulates the kinetic and motile properties of porcine β-cardiac myosin.
Yingying Liu, Howard D White, Betty Belknap, Donald A Winkelmann, Eva Forgacs

Biochemistry· March 2015

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A periodic pattern of evolutionarily conserved basic and acidic residues constitutes the binding interface of actin-tropomyosin.
Bipasha Barua, Patricia M Fagnant, Donald A Winkelmann, Kathleen M Trybus, Sarah E Hitchcock-DeGregori

J Biol Chem· April 2013

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Regulation of actin-myosin interaction by conserved periodic sites of tropomyosin.
Bipasha Barua, Donald A Winkelmann, Howard D White, Sarah E Hitchcock-DeGregori

Proc Natl Acad Sci U S A· November 2012

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Unc45 activates Hsp90-dependent folding of the myosin motor domain.
Li Liu, Rajani Srikakulam, Donald A Winkelmann

J Biol Chem· May 2008

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Unc45b forms a cytosolic complex with Hsp90 and targets the unfolded myosin motor domain.
Rajani Srikakulam, Li Liu, Donald A Winkelmann

PLoS One· May 2008

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Chaperone-mediated folding and assembly of myosin in striated muscle.
Rajani Srikakulam, Donald A Winkelmann

J Cell Sci· February 2004

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Mutations in the motor domain modulate myosin activity and myofibril organization.
Qun Wang, Carole L Moncman, Donald A Winkelmann

J Cell Sci· October 2003

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Folding of the striated muscle myosin motor domain.
Diana Chow, Rajani Srikakulam, Ying Chen, Donald A Winkelmann

J Biol Chem· September 2002

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