Publications by authors named "Donald Awrey"

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Design and optimization of (3-aryl-1H-indazol-6-yl)spiro[cyclopropane-1,3'-indolin]-2'-ones as potent PLK4 inhibitors with oral antitumor efficacy.
Sze-Wan Li, Yong Liu, Peter B Sampson, Narendra Kumar Patel, Bryan T Forrest, Donald E Awrey

Bioorg Med Chem Lett· October 2016

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Discovery of 4-(4-aminopyrazolo[1,5-a][1,3,5]triazin-8-yl)benzamides as novel, highly potent and selective, orally bioavailable inhibitors of Tyrosine Threonine Kinase, TTK.
Radoslaw Laufer, Sze-Wan Li, Yong Liu, Grace Ng, Yunhui Lang, Donald E Awrey

Bioorg Med Chem Lett· August 2016

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Discovery of Pyrazolo[1,5-a]pyrimidine TTK Inhibitors: CFI-402257 is a Potent, Selective, Bioavailable Anticancer Agent.
Yong Liu, Radoslaw Laufer, Narendra Kumar Patel, Grace Ng, Peter B Sampson, Donald E Awrey

ACS Med Chem Lett· July 2016

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The Discovery of Orally Bioavailable Tyrosine Threonine Kinase (TTK) Inhibitors: 3-(4-(heterocyclyl)phenyl)-1H-indazole-5-carboxamides as Anticancer Agents.
Yong Liu, Yunhui Lang, Narendra Kumar Patel, Grace Ng, Radoslaw Laufer, Donald E Awrey

J Med Chem· April 2015

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The discovery of Polo-like kinase 4 inhibitors: design and optimization of spiro[cyclopropane-1,3'[3H]indol]-2'(1'H).ones as orally bioavailable antitumor agents.
Peter B Sampson, Yong Liu, Narendra Kumar Patel, Miklos Feher, Bryan Forrest, Donald E Awrey

J Med Chem· January 2015

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The discovery of Polo-like kinase 4 inhibitors: identification of (1R,2S).2-(3-((E).4-(((cis).2,6-dimethylmorpholino)methyl)styryl). 1H.indazol-6-yl)-5'-methoxyspiro[cyclopropane-1,3'-indolin]-2'-one (CFI-400945) as a potent, orally active antitumor agent.
Peter B Sampson, Yong Liu, Bryan Forrest, Graham Cumming, Sze-Wan Li, Donald E Awrey

J Med Chem· January 2015

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Functional characterization of CFI-400945, a Polo-like kinase 4 inhibitor, as a potential anticancer agent.
Jacqueline M Mason, Dan Chi-Chia Lin, Xin Wei, Yi Che, Yi Yao, Donald E Awrey

Cancer Cell· August 2014

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The discovery of PLK4 inhibitors: (E)-3-((1H-Indazol-6-yl)methylene)indolin-2-ones as novel antiproliferative agents.
Radoslaw Laufer, Bryan Forrest, Sze-Wan Li, Yong Liu, Peter Sampson, Donald E Awrey

J Med Chem· August 2013

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Hyperphosphorylation of glucosyl C6 carbons and altered structure of glycogen in the neurodegenerative epilepsy Lafora disease.
Felix Nitschke, Peixiang Wang, Peter Schmieder, Jean-Marie Girard, Donald E Awrey

Cell Metab· May 2013

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In vitro activity (MICs and rate of kill) of AFN-1252, a novel FabI inhibitor, in the presence of serum and in combination with other antibiotics.
Nachum Kaplan, Donald Awrey, Elias Bardouniotis, Judd Berman, Jeremy Yethon

J Chemother· February 2013

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Mode of action, in vitro activity, and in vivo efficacy of AFN-1252, a selective antistaphylococcal FabI inhibitor.
Nachum Kaplan, Monique Albert, Donald Awrey, Elias Bardouniotis, Judd Berman

Antimicrob Agents Chemother· November 2012

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2,3,4,5-Tetrahydro-1H-pyrido[2,3-b and e][1,4]diazepines as inhibitors of the bacterial enoyl ACP reductase, FabI.
Jailall Ramnauth, Mathew D Surman, Peter B Sampson, Bryan Forrest, Jeff Wilson, Donald E Awrey

Bioorg Med Chem Lett· September 2009

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Spiro-naphthyridinone piperidines as inhibitors of S. aureus and E. coli enoyl-ACP reductase (FabI).
Peter B Sampson, Christine Picard, Sean Handerson, Teresa E McGrath, Megan Domagala, Donald E Awrey

Bioorg Med Chem Lett· September 2009

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Systematic characterization of the protein interaction network and protein complexes in Saccharomyces cerevisiae using tandem affinity purification and mass spectrometry.
Mohan Babu, Nevan J Krogan, Donald E Awrey, Andrew Emili, Jack F Greenblatt

Methods Mol Biol· July 2009

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Screening for ligands using a generic and high-throughput light-scattering-based assay.
Guillermo A Senisterra, Eugene Markin, Ken Yamazaki, Raymond Hui, Masoud Vedadi, Donald E Awrey

J Biomol Screen· December 2006

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Intrinsic transcript cleavage in yeast RNA polymerase II elongation complexes.
Rodney G Weilbaecher, Donald E Awrey, Aled M Edwards, Caroline M Kane

J Biol Chem· June 2003

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Cytoskeleton interactions involved in the assembly and function of glycoprotein-80 adhesion complexes in dictyostelium.
Tony J C Harris, Amir Ravandi, Donald E Awrey, Chi-Hung Siu

J Biol Chem· January 2003

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