Publications by authors named "Donald B Defranco"

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Estrogen regulation in the prostate underlies racial disparity in men with benign prostatic hyperplasia.
Teresa T Liu, Laura E Pascal, Emily A Ricke, Ana Lucila Bautista-Ruiz, Justin Townsend, Donald B DeFranco

J Pathol· November 2025

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ZC3H4, a novel regulator of mitochondrial complex I, impacts prostate stromal cell senescence, attachment, adhesion and anoikis resistance.
Teresa T Liu, Mia J Carrarini, Livianna K Myklebust, Kegan O Skalitzky, Nathalie El-Khoury, Donald B DeFranco

Cell Death Dis· October 2025

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Physiologic and structural characterization of desisobutyryl-ciclesonide, a selective glucocorticoid receptor modulator in newborn rats.
Juliann D Jaumotte, Nathalie El Khoury, Charles K Min, Jiefei Wang, Caroline Madigan, Donald B DeFranco

PNAS Nexus· January 2025

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Benign prostatic hyperplasia nodules in patients treated with celecoxib and/or finasteride have reduced levels of NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, a mitochondrial protein essential for efficient function of the electron transport chain.
Teresa T Liu, Taro Igarashi, Nathalie El-Khoury, Nnamdi Ihejirika, Kelsey Paxton, Donald B DeFranco

Prostate· October 2024

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Aging-Related Mitochondrial Dysfunction Is Associated With Fibrosis in Benign Prostatic Hyperplasia.
Alexis E Adrian, Teresa T Liu, Laura E Pascal, Scott R Bauer, Donald B DeFranco

J Gerontol A Biol Sci Med Sci· June 2024

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Age-Dependent Effects of Voluntary Wheel Running Exercise on Voiding Behavior and Potential Age-Related Molecular Mechanisms in Mice.
Teresa T Liu, Laura E Pascal, Scott R Bauer, Hannah N Miles, Jules B Panksepp, Donald B DeFranco

J Gerontol A Biol Sci Med Sci· June 2024

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Residency Program Directors' Views on Research Conducted During Medical School: A National Survey.
Rachel K Wolfson, Paige C Fairchild, Ingrid Bahner, Dwayne M Baxa, Deborah R Birnbaum, Donald B DeFranco

Acad Med· October 2023

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The SARS-CoV-2 E protein induces Toll-like receptor 2-mediated neonatal lung injury in a model of COVID-19 viremia that is rescued by the glucocorticoid ciclesonide.
Heather L Menden, Sherry M Mabry, Aparna Venkatraman, Sheng Xia, Donald B DeFranco

Am J Physiol Lung Cell Mol Physiol· May 2023

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Genomic glucocorticoid action in embryonic mouse neural stem cells.
Kimberly J Berry, Uma Chandran, Fangping Mu, Dinesh K Deochand, T Lei, Donald B DeFranco

Mol Cell Endocrinol· March 2023

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Genetic alterations in CREBRF influence prostate cancer survival and impact prostate tissue homeostasis in mice.
Laura E Pascal, Krystle A Frahm, Kegan O Skalitzky, Donald B DeFranco, Lora H Rigatti

Am J Clin Exp Urol· February 2023

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Increased COX-1 expression in benign prostate epithelial cells is triggered by mitochondrial dysfunction.
Chandler N Hudson, Kai He, Laura E Pascal, Teresa Liu, Livianna K Myklebust, Donald B DeFranco

Am J Clin Exp Urol· August 2022

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E-cadherin deficiency promotes prostate macrophage inflammation and bladder overactivity in aged male mice.
Laura E Pascal, Taro Igarashi, Shinsuke Mizoguchi, Wei Chen, Lora H Rigatti, Donald B DeFranco

Aging (Albany NY)· March 2022

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Ciclesonide activates glucocorticoid signaling in neonatal rat lung but does not trigger adverse effects in the cortex and cerebellum.
Juliann D Jaumotte, Alexis L Franks, Erin M Bargerstock, Edwina Philip Kisanga, Heather L Menden, Donald B DeFranco

Neurobiol Dis· August 2021

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Impact of A Required, Longitudinal Scholarly Project in Medical School: A Content Analysis of Medical Students' Reflections.
Tanya Nikiforova, Andrea Carter, Judy C Chang, Donald B DeFranco, Peter J Veldkamp

Med Sci Educ· August 2021

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Pten-NOLC1 fusion promotes cancers involving MET and EGFR signalings.
Jian-Hua Luo, Silvia Liu, Junyan Tao, Bao-Guo Ren, Katherine Luo, Donald B DeFranco

Oncogene· February 2021

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Claudin-1 down-regulation in the prostate is associated with aging and increased infiltration of inflammatory cells in BPH.
Laura E Pascal, Rajiv Dhir, Goundappa K Balasubramani, Wei Chen, Chandler N Hudson, Donald B DeFranco

Am J Clin Exp Urol· February 2021

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E-cadherin expression is inversely correlated with aging and inflammation in the prostate.
Laura E Pascal, Rajiv Dhir, Goundappa K Balasubramani, Wei Chen, Chandler N Hudson, Donald B DeFranco

Am J Clin Exp Urol· February 2021

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Prostate-Specific Deletion of Cdh1 Induces Murine Prostatic Inflammation and Bladder Overactivity.
Laura E Pascal, Shinsuke Mizoguchi, Wei Chen, Lora H Rigatti, Taro Igarashi, Donald B DeFranco

Endocrinology· January 2021

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Effects of dutasteride in a rat model of chemically induced prostatic inflammation-Potential role of estrogen receptor β.
Shinsuke Mizoguchi, Kenichi Mori, Toshitaka Shin, Zhou Wang, Donald B DeFranco

Prostate· December 2020

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Loss of CREBRF Reduces Anxiety-like Behaviors and Circulating Glucocorticoids in Male and Female Mice.
Krystle A Frahm, Akeem A Williams, Ashlee N Wood, Michael C Ewing, Polly E Mattila, Donald B DeFranco

Endocrinology· November 2020

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Differential impact of paired patient-derived BPH and normal adjacent stromal cells on benign prostatic epithelial cell growth in 3D culture.
Wei Chen, Laura E Pascal, Ke Wang, Rajiv Dhir, Alexa M Sims, Donald B DeFranco

Prostate· October 2020

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Tight junction protein claudin-1 is downregulated by TGF-β1 via MEK signaling in benign prostatic epithelial cells.
Ke Wang, Laura E Pascal, Feng Li, Wei Chen, Rajiv Dhir, Donald B DeFranco

Prostate· October 2020

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Transforming growth factor beta 1 impairs benign prostatic luminal epithelial cell monolayer barrier function.
Feng Li, Laura E Pascal, Ke Wang, Yibin Zhou, Goundappa K Balasubramani, Donald B DeFranco

Am J Clin Exp Urol· February 2020

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Prenatal drug exposure and neurodevelopmental programming of glucocorticoid signalling.
Alexis L Franks, Kimberly J Berry, Donald B DeFranco

J Neuroendocrinol· January 2020

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E-cadherin is downregulated in benign prostatic hyperplasia and required for tight junction formation and permeability barrier in the prostatic epithelial cell monolayer.
Feng Li, Laura E Pascal, Donna B Stolz, Ke Wang, Yibin Zhou, Donald B DeFranco

Prostate· August 2019

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