Publications by authors named "Donald D Muccio"

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Next-generation retinoid X receptor agonists increase ATRA signaling in organotypic epithelium cultures and have distinct effects on receptor dynamics.
Nathalia Melo, Olga V Belyaeva, Wilhelm K Berger, Laszlo Halasz, Jianshi Yu, Donald D Muccio

J Biol Chem· January 2023

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Conformationally Defined Rexinoids for the Prevention of Inflammation and Nonmelanoma Skin Cancers.
Venkatram R Atigadda, Mahendra P Kashyap, Zhengrong Yang, Debasish Chattopadhyay, Nathalia Melo, Donald D Muccio

J Med Chem· November 2022

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Stability of the Retinoid X Receptor-α Homodimer in the Presence and Absence of Rexinoid and Coactivator Peptide.
Zhengrong Yang, Donald D Muccio, Nathalia Melo, Venkatram R Atigadda, Matthew B Renfrow

Biochemistry· April 2021

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A Small Molecule, UAB126, Reverses Diet-Induced Obesity and its Associated Metabolic Disorders.
Guang Ren, Teayoun Kim, Hae-Suk Kim, Martin E Young, Donald D Muccio

Diabetes· September 2020

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A Randomized, Placebo-Controlled, Double-Blind, Dose Escalation, Single Dose, and Steady-State Pharmacokinetic Study of 9cUAB30 in Healthy Volunteers.
Jill M Kolesar, Shannon Andrews, Heather Green, Tom C Havighurst, Barbara W Wollmer, Donald D Muccio

Cancer Prev Res (Phila)· December 2019

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A novel retinoid X receptor agonist, UAB30, inhibits rhabdomyosarcoma cells in vitro.
Adele P Williams, Alicia M Waters, Jerry E Stewart, Venkatram R Atigadda, Elizabeth Mroczek-Musulman, Donald D Muccio

J Surg Res· August 2018

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The retinoid X receptor agonist, 9-cis UAB30, inhibits cutaneous T-cell lymphoma proliferation through the SKP2-p27kip1 axis.
Chu-Fang Chou, Yu-Hua Hsieh, Clinton J Grubbs, Venkatram R Atigadda, James A Mobley, Donald D Muccio

J Dermatol Sci· June 2018

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Translation of a Tissue-Selective Rexinoid, UAB30, to the Clinic for Breast Cancer Prevention.
Donald D Muccio, Venkatram R Atigadda, Wayne J Brouillette, Kirby I Bland, Helen Krontiras

Curr Top Med Chem· February 2017

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Retinoid X Receptor Agonists Upregulate Genes Responsible for the Biosynthesis of All-Trans-Retinoic Acid in Human Epidermis.
Lizhi Wu, Sandeep C Chaudhary, Venkatram R Atigadda, Olga V Belyaeva, Steven R Harville, Donald D Muccio

PLoS One· September 2016

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Preclinical Evaluation of UAB30 in Pediatric Renal and Hepatic Malignancies.
Alicia M Waters, Jerry E Stewart, Venkatram R Atigadda, Elizabeth Mroczek-Musulman, Donald D Muccio

Mol Cancer Ther· May 2016

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Conformationally Defined Rexinoids and Their Efficacy in the Prevention of Mammary Cancers.
Venkatram R Atigadda, Gang Xia, Anil Deshpande, Lizhi Wu, Natalia Kedishvili, Donald D Muccio

J Med Chem· October 2015

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Preclinical Evaluation of a Novel RXR Agonist for the Treatment of Neuroblastoma.
Alicia M Waters, Jerry E Stewart, Venkatram R Atigadda, Elizabeth Mroczek-Musulman, Donald D Muccio

Mol Cancer Ther· July 2015

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Methyl substitution of a rexinoid agonist improves potency and reveals site of lipid toxicity.
Venkatram R Atigadda, Gang Xia, Anil Desphande, LeeAnn J Boerma, Susan Lobo-Ruppert, Donald D Muccio

J Med Chem· June 2014

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Defining the communication between agonist and coactivator binding in the retinoid X receptor α ligand binding domain.
Leeann J Boerma, Gang Xia, Cheng Qui, Bryan D Cox, Michael J Chalmers, Donald D Muccio

J Biol Chem· January 2014

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Methyl-substituted conformationally constrained rexinoid agonists for the retinoid X receptors demonstrate improved efficacy for cancer therapy and prevention.
Anil Desphande, Gang Xia, LeeAnn J Boerma, Kimberly K Vines, Venkatram R Atigadda, Donald D Muccio

Bioorg Med Chem· January 2014

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Conformational Analysis of Retinoic Acids: Effects of Steric Interactions on Nonplanar Conjugated Polyenes.
Bryan D Cox, Donald D Muccio, Tracy P Hamilton

Comput Theor Chem· May 2013

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Effects on gene expression in rat liver after administration of RXR agonists: UAB30, 4-methyl-UAB30, and Targretin (Bexarotene).
Peter T Vedell, Yan Lu, Clinton J Grubbs, Yuxin Yin, Hui Jiang, Donald D Muccio

Mol Pharmacol· March 2013

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The CDK4/6 inhibitor PD0332991 reverses epithelial dysplasia associated with abnormal activation of the cyclin-CDK-Rb pathway.
M Carla Cabrera, Edgar S Díaz-Cruz, Bhaskar V S Kallakury, Michael J Pishvaian, Clinton J Grubbs, Donald D Muccio

Cancer Prev Res (Phila)· June 2012

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The impact of novel retinoids in combination with platinum chemotherapy on ovarian cancer stem cells.
Jenny M Whitworth, Angelina I Londoño-Joshi, Jeffrey C Sellers, Patsy J Oliver, Donald D Muccio

Gynecol Oncol· April 2012

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The use of retinoids in ovarian cancer: a review of the literature.
Jenny M Whitworth, J Michael Straughn, Venkatram R Atigadda, Donald D Muccio, Donald J Buchsbaum

Int J Gynecol Cancer· February 2012

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A CXCL8 receptor antagonist based on the structure of N-acetyl-proline-glycine-proline.
Patricia L Jackson, Brett D Noerager, Michael J Jablonsky, Matthew T Hardison, Bryan D Cox, Donald D Muccio

Eur J Pharmacol· October 2011

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Structure, energetics, and dynamics of binding coactivator peptide to the human retinoid X receptor α ligand binding domain complex with 9-cis-retinoic acid.
Gang Xia, LeeAnn J Boerma, Bryan D Cox, Cheng Qiu, Sebyung Kang, Donald D Muccio

Biochemistry· January 2011

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Prevention of KLF4-mediated tumor initiation and malignant transformation by UAB30 rexinoid.
Wen Jiang, Wentao Deng, Sarah K Bailey, Clint D Nail, Andra R Frost, Donald D Muccio

Cancer Biol Ther· February 2009

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The Novel Retinoid, 9cUAB30, Inhibits Telomerase and Induces Apoptosis in HL60 Cells.
William K Love, J Tyson Deangelis, Joel B Berletch, Sharla Mo Phipps, Lucy G Andrews, Donald D Muccio

Transl Oncol· September 2008

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In vitro metabolic characterization, phenotyping, and kinetic studies of 9cUAB30, a retinoid X receptor-specific retinoid.
Gregory S Gorman, Lori Coward, Corenna Kerstner-Wood, Lea Cork, Izet M Kapetanovic, Donald D Muccio

Drug Metab Dispos· July 2007

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