Publications by authors named "Donald Heald"

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Minimal Physiologically Based Pharmacokinetic-Pharmacodynamic (mPBPK-PD) Model of -Acetylgalactosamine-Conjugated Small Interfering RNA Disposition and Gene Silencing in Preclinical Species and Humans.
Vivaswath S Ayyar, Dawei Song, Songmao Zheng, Thomas Carpenter, Donald L Heald

J Pharmacol Exp Ther· November 2021

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Bench-to-bedside translation of chimeric antigen receptor (CAR) T cells using a multiscale systems pharmacokinetic-pharmacodynamic model: A case study with anti-BCMA CAR-T.
Aman P Singh, Wenbo Chen, Xirong Zheng, Hardik Mody, Thomas J Carpenter, Donald L Heald

CPT Pharmacometrics Syst Pharmacol· April 2021

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Model-Based Cellular Kinetic Analysis of Chimeric Antigen Receptor-T Cells in Humans.
Can Liu, Vivaswath S Ayyar, Xirong Zheng, Wenbo Chen, Songmao Zheng, Donald Heald

Clin Pharmacol Ther· March 2021

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Development of a quantitative relationship between CAR-affinity, antigen abundance, tumor cell depletion and CAR-T cell expansion using a multiscale systems PK-PD model.
Aman P Singh, Xirong Zheng, Xiefan Lin-Schmidt, Wenbo Chen, Thomas J Carpenter, Donald L Heald

MAbs· January 2021

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Geriatrics 2030: Developing Drugs to Care for Older Persons-A Neglected and Growing Population.
S W Johnny Lau, Jan-Frederik Schlender, Patricia W Slattum, Donald L Heald, Robin O'Connor-Semmes

Clin Pharmacol Ther· January 2020

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Development of a Target cell-Biologics-Effector cell (TBE) complex-based cell killing model to characterize target cell depletion by T cell redirecting bispecific agents.
Xiling Jiang, Xi Chen, Thomas J Carpenter, Jun Wang, Rebecca Zhou, Donald L Heald

MAbs· February 2019

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Best practices for the use of itraconazole as a replacement for ketoconazole in drug-drug interaction studies.
Lichuan Liu, Akintunde Bello, Mark J Dresser, Donald Heald, Steven Ferenc Komjathy

J Clin Pharmacol· February 2016

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Clinical pharmacology, creating current and future success in drug development.
Mark C Rogge, Mark Dresser, Michael Fossler, Donald Heald, S Aubrey Stoch

J Clin Pharmacol· November 2015

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Molecular properties determining unbound intracellular and extracellular brain exposure of CNS drug candidates.
Irena Loryan, Vikash Sinha, Claire Mackie, Achiel Van Peer, Wilhelmus H Drinkenburg, Donald Heald

Mol Pharm· February 2015

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Pharmacokinetic interactions between topiramate and pioglitazone and metformin.
Prasarn Manitpisitkul, Christopher R Curtin, Kevin Shalayda, Shean-Sheng Wang, Lisa Ford, Donald Heald

Epilepsy Res· November 2014

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Pharmacokinetic interactions between topiramate and diltiazem, hydrochlorothiazide, or propranolol.
Prasarn Manitpisitkul, Christopher R Curtin, Kevin Shalayda, Shean-Sheng Wang, Lisa Ford, Donald Heald

Clin Pharmacol Drug Dev· September 2014

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Mechanistic understanding of brain drug disposition to optimize the selection of potential neurotherapeutics in drug discovery.
Irena Loryan, Vikash Sinha, Claire Mackie, Achiel Van Peer, Wilhelmus Drinkenburg, Donald Heald

Pharm Res· August 2014

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Pharmacokinetics of topiramate in patients with renal impairment, end-stage renal disease undergoing hemodialysis, or hepatic impairment.
Prasarn Manitpisitkul, Christopher R Curtin, Kevin Shalayda, Shean-Sheng Wang, Lisa Ford, Donald L Heald

Epilepsy Res· July 2014

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An open-label drug-drug interaction study of the steady-state pharmacokinetics of topiramate and glyburide in patients with type 2 diabetes mellitus.
Prasarn Manitpisitkul, Christopher R Curtin, Kevin Shalayda, Shean-Sheng Wang, Lisa Ford, Donald L Heald

Clin Drug Investig· December 2013

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From preclinical to human--prediction of oral absorption and drug-drug interaction potential using physiologically based pharmacokinetic (PBPK) modeling approach in an industrial setting: a workflow by using case example.
Vikash Kumar Sinha, Jan Snoeys, Nancy Van Osselaer, Achiel Van Peer, Claire Mackie, Donald Heald

Biopharm Drug Dispos· March 2012

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Pharmacokinetics of enoxaparin in patients undergoing percutaneous coronary intervention with and without glycoprotein IIb/IIIa therapy.
Domenick Argenti, Debra Hoppensteadt, Donald Heald, Brad Jensen, Jaweed Fareed

Am J Ther· November 2003

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Comparative Pharmacokinetics and Bioavailability of Dilacor XR and Cardizem CD in Healthy Volunteers.
Domenick Argenti, Mei-Yung Huang, Donald Heald, John Ziemniak

Am J Ther· January 1995

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The Pharmacokinetics of Once-Daily Diltiazem SR (Sustained-Release) in Young Versus Elderly Hypertensive Patients.
Domenick Argenti, Mei-Ying Huang, Donald Heald, John Ziemniak

Am J Ther· August 1994

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