Publications by authors named "Donald J Kyle"

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The nociceptin/orphanin FQ receptor partial agonist sunobinop promotes non-REM sleep in rodents and patients with insomnia.
Garth T Whiteside, Donald J Kyle, Ram P Kapil, Alessandra Cipriano, Ellie He

J Clin Invest· January 2024

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Hyperthermia induced by transient receptor potential vanilloid-1 (TRPV1) antagonists in human clinical trials: Insights from mathematical modeling and meta-analysis.
Andras Garami, Yury P Shimansky, Zoltan Rumbus, Robson C L Vizin, Nelli Farkas, Donald J Kyle

Pharmacol Ther· April 2020

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N-Aryl azacycles as novel sodium channel blockers.
Stephen M Lynch, Laykea Tafesse, Kevin Carlin, Parijat Ghatak, Bin Shao, Donald J Kyle

Bioorg Med Chem Lett· January 2015

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Dibenzazepines and dibenzoxazepines as sodium channel blockers.
Stephen M Lynch, Laykea Tafesse, Kevin Carlin, Parijat Ghatak, Donald J Kyle

Bioorg Med Chem Lett· January 2015

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Studies examining the relationship between the chemical structure of protoxin II and its activity on voltage gated sodium channels.
Jae H Park, Kevin P Carlin, Gang Wu, Victor I Ilyin, Laszlo L Musza, Donald J Kyle

J Med Chem· August 2014

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Structure-activity relationship studies and discovery of a potent transient receptor potential vanilloid (TRPV1) antagonist 4-[3-chloro-5-[(1S)-1,2-dihydroxyethyl]-2-pyridyl]-N-[5-(trifluoromethyl)-2-pyridyl]-3,6-dihydro-2H-pyridine-1-carboxamide (V116517) as a clinical candidate for pain management.
Laykea Tafesse, Toshiyuki Kanemasa, Noriyuki Kurose, Jianming Yu, Toshiyuki Asaki, Donald J Kyle

J Med Chem· August 2014

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Roles of μ-opioid receptors and nociceptin/orphanin FQ peptide receptors in buprenorphine-induced physiological responses in primates.
Colette M Cremeans, Erin Gruley, Donald J Kyle, Mei-Chuan Ko

J Pharmacol Exp Ther· October 2012

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Cysteine racemization during the Fmoc solid phase peptide synthesis of the Nav1.7-selective peptide--protoxin II.
Jae H Park, Kevin P Carlin, Gang Wu, Victor I Ilyin, Donald J Kyle

J Pept Sci· July 2012

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Sodium channel blockers.
Donald J Kyle, Victor I Ilyin

J Med Chem· May 2007

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Efficient medicinal chemistry.
Donald J Kyle

Comb Chem High Throughput Screen· February 2006

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Display of somatostatin-related peptides in the complementarity determining regions of an antibody light chain.
Peter J Simon, Kevin C Brogle, Baiyang Wang, Donald J Kyle, Daniel A Soltis

Arch Biochem Biophys· August 2005

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8-Substituted analogues of 3-(3-cyclopentyloxy-4-methoxy-benzyl)-8-isopropyl-adenine: highly potent and selective PDE4 inhibitors.
John W F Whitehead, Gary P Lee, Parviz Gharagozloo, Peter Hofer, André Gehrig, Donald J Kyle

J Med Chem· February 2005

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Design and synthesis of 4-phenyl piperidine compounds targeting the mu receptor.
Zhengming Chen, Ellen Davies, Wendy S Miller, Shen Shan, Kenneth J Valenzano, Donald J Kyle

Bioorg Med Chem Lett· November 2004

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Synthesis and evaluation of pyridazinylpiperazines as vanilloid receptor 1 antagonists.
Laykea Tafesse, Qun Sun, Lori Schmid, Kenneth J Valenzano, Yakov Rotshteyn, Donald J Kyle

Bioorg Med Chem Lett· November 2004

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1,3-Dihydro-2,1,3-benzothiadiazol-2,2-diones and 3,4-dihydro-1H-2,1,3-benzothidiazin-2,2-diones as ligands for the NOP receptor.
R Richard Goehring, John F W Whitehead, K Brown, Khondaker Islam, Xin Wen, Donald J Kyle

Bioorg Med Chem Lett· October 2004

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DiPOA ([8-(3,3-diphenyl-propyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-3-yl]-acetic acid), a novel, systemically available, and peripherally restricted mu opioid agonist with antihyperalgesic activity: I. In vitro pharmacological characterization and pharmacokinetic properties.
Kenneth J Valenzano, Wendy Miller, Zhengming Chen, Shen Shan, Gregg Crumley, Donald J Kyle

J Pharmacol Exp Ther· August 2004

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Design and synthesis of novel small molecule N/OFQ receptor antagonists.
Zhengming Chen, R Richard Goehring, Kenneth J Valenzano, Donald J Kyle

Bioorg Med Chem Lett· March 2004

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An efficient parallel synthesis of capsazepine and capsazepine analogs.
Laykea Tafesse, Donald J Kyle

Comb Chem High Throughput Screen· March 2004

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4-(2-pyridyl)piperazine-1-carboxamides: potent vanilloid receptor 1 antagonists.
Qun Sun, Laykea Tafesse, Khondaker Islam, Xiaoming Zhou, Sam F Victory, Donald J Kyle

Bioorg Med Chem Lett· October 2003

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Parallel synthesis of a biased library of thiazolidinones as novel sodium channel antagonists.
Qun Sun, Laykea Tafesse, James T Limberis, Khondekar Islam, Donald J Kyle

Comb Chem High Throughput Screen· August 2003

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Pharmacology of a new cyclic nucleotide phosphodiesterase type 4 inhibitor, V11294.
Donna D Gale, Peter Hofer, Domenico Spina, Esther A Seeds, Katherine H Banner, Donald J Kyle

Pulm Pharmacol Ther· July 2003

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Human B1 and B2 bradykinin receptors and their agonists target caveolae-related lipid rafts to different degrees in HEK293 cells.
Maria E Lamb, Chongwu Zhang, Thomas Shea, Donald J Kyle, L M Fredrik Leeb-Lundberg

Biochemistry· December 2002

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Novel, potent ORL-1 receptor agonist peptides containing alpha-Helix-promoting conformational constraints.
Chongwu Zhang, Wendy Miller, Kenneth J Valenzano, Donald J Kyle

J Med Chem· November 2002

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Solid-phase and solution-phase parallel synthesis of tetrahydro-isoquinolines via Pictet-Spengler reaction.
Qun Sun, Donald J Kyle

Comb Chem High Throughput Screen· February 2002

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