Publications by authors named "Dosh Whye"

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Excitatory cortical neurons from CDKL5 deficiency disorder patient-derived organoids show early hyperexcitability not identified in neurogenin2 induced neurons.
Madison R Glass, Dosh Whye, Nickesha C Anderson, Delaney Wood, Nina R Makhortova

Neurobiol Dis· October 2025

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An open-source pipeline for calcium imaging and all-optical physiology in human stem cell-derived neurons.
Wardiya Afshar-Saber, Federico M Gasparoli, Ziqin Yang, Nicole A Teaney, Lahin Lalani, Dosh Whye

bioRxiv· July 2025

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Excitatory Cortical Neurons from CDKL5 Deficiency Disorder Patient-Derived Organoids Show Early Hyperexcitability Not Identified in Neurogenin2 Induced Neurons.
Madison R Glass, Dosh Whye, Nickesha C Anderson, Delaney Wood, Nina R Makhortova

bioRxiv· November 2024

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A Hybrid 2D-to-3D in vitro Differentiation Platform Improves Outcomes of Cerebral Cortical Organoid Generation in hiPSCs.
Dosh Whye, Erika M Norabuena, Gayathri Rajaram Srinivasan, Delaney Wood, Taryn J Polanco

Curr Protoc· October 2024

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Rigor and reproducibility in human brain organoid research: Where we are and where we need to go.
Soraya O Sandoval, Gerarda Cappuccio, Karina Kruth, Sivan Osenberg, Saleh M Khalil, Dosh Whye

Stem Cell Reports· June 2024

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Cortical neurons obtained from patient-derived iPSCs with GNAO1 p.G203R variant show altered differentiation and functional properties.
Maria Cristina Benedetti, Tiziano D'andrea, Alessio Colantoni, Denis Silachev, Valeria de Turris, Dosh Whye

Heliyon· March 2024

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High-content screening identifies a small molecule that restores AP-4-dependent protein trafficking in neuronal models of AP-4-associated hereditary spastic paraplegia.
Afshin Saffari, Barbara Brechmann, Cedric Böger, Wardiya Afshar Saber, Hellen Jumo, Dosh Whye

Nat Commun· January 2024

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High-Content Small Molecule Screen Identifies a Novel Compound That Restores AP-4-Dependent Protein Trafficking in Neuronal Models of AP-4-Associated Hereditary Spastic Paraplegia.
Afshin Saffari, Barbara Brechmann, Cedric Boeger, Wardiya Afshar Saber, Hellen Jumo, Dosh Whye

Res Sq· June 2023

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A Robust Pipeline for the Multi-Stage Accelerated Differentiation of Functional 3D Cortical Organoids from Human Pluripotent Stem Cells.
Dosh Whye, Delaney Wood, Wardiya Afshar Saber, Erika M Norabuena, Nina R Makhortova

Curr Protoc· January 2023

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Dynamic 3D Combinatorial Generation of hPSC-Derived Neuromesodermal Organoids With Diverse Regional and Cellular Identities.
Dosh Whye, Delaney Wood, Kristina H Kim, Cidi Chen, Nina Makhortova

Curr Protoc· October 2022

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Crossing unlikely paths in science.
Dosh Whye

J Cell Sci· May 2022

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Applying Deep Neural Network Analysis to High-Content Image-Based Assays.
Samuel J Yang, Scott L Lipnick, Nina R Makhortova, Subhashini Venugopalan, Minjie Fan, Dosh Whye

SLAS Discov· September 2019

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Efficient differentiation of mouse embryonic stem cells into motor neurons.
Chia-Yen Wu, Dosh Whye, Robert W Mason, Wenlan Wang

J Vis Exp· June 2012

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Targeting nonclassical oncogenes for therapy in T-ALL.
Prem S Subramaniam, Dosh W Whye, Evgeni Efimenko, Jianchung Chen, Valeria Tosello

Cancer Cell· April 2012

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Proteomic assessment of a cell model of spinal muscular atrophy.
Chia-Yen Wu, Dosh Whye, Lisa Glazewski, Leila Choe, Douglas Kerr

BMC Neurosci· March 2011

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