Publications by authors named "Douglas B Kitchen"

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A humanized monoclonal antibody targeting an ectonucleotidase rescues cardiac metabolism and heart function after myocardial infarction.
Shen Li, Bo Tao, Jijun Wan, Enca Montecino-Rodriguez, Ping Wang, Douglas B Kitchen

Cell Rep Med· November 2024

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Design, Synthesis, and Preclinical Efficacy of Novel Nonretinoid Antagonists of Retinol-Binding Protein 4 in the Mouse Model of Hepatic Steatosis.
Christopher L Cioffi, Boglarka Racz, Andras Varadi, Emily E Freeman, Michael P Conlon, Douglas B Kitchen

J Med Chem· June 2019

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Discovery of Small-Molecule Antibiotics against a Unique tRNA-Mediated Regulation of Transcription in Gram-Positive Bacteria.
Kyla M Frohlich, Spencer F Weintraub, Janeen T Bell, Gabrielle C Todd, Ville Y P Väre, Douglas B Kitchen

ChemMedChem· April 2019

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Design and Characterization of Novel Covalent Bromodomain and Extra-Terminal Domain (BET) Inhibitors Targeting a Methionine.
Olesya A Kharenko, Reena G Patel, S David Brown, Cyrus Calosing, Andre White, Douglas B Kitchen

J Med Chem· September 2018

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Computer-aided drug discovery research at a global contract research organization.
Douglas B Kitchen

J Comput Aided Mol Des· March 2017

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Systems biology-guided identification of synthetic lethal gene pairs and its potential use to discover antibiotic combinations.
Ramy K Aziz, Jonathan M Monk, Robert M Lewis, Suh In Loh, Arti Mishra, Douglas B Kitchen

Sci Rep· November 2015

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Model-driven discovery of synergistic inhibitors against E. coli and S. enterica serovar Typhimurium targeting a novel synthetic lethal pair, aldA and prpC.
Ramy K Aziz, Valerie L Khaw, Jonathan M Monk, Elizabeth Brunk, Robert Lewis, Douglas B Kitchen

Front Microbiol· October 2015

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Bicyclic [3.3.0]-Octahydrocyclopenta[c]pyrrolo Antagonists of Retinol Binding Protein 4: Potential Treatment of Atrophic Age-Related Macular Degeneration and Stargardt Disease.
Christopher L Cioffi, Boglarka Racz, Emily E Freeman, Michael P Conlon, Ping Chen, Douglas B Kitchen

J Med Chem· August 2015

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Discovery of a new chemical series of BRD4(1) inhibitors using protein-ligand docking and structure-guided design.
Bryan C Duffy, Shuang Liu, Gregory S Martin, Ruifang Wang, Ming Min Hsia, Douglas B Kitchen

Bioorg Med Chem Lett· July 2015

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Lead optimization toward proof-of-concept tools for Huntington's disease within a 4-(1H-pyrazol-4-yl)pyrimidine class of pan-JNK inhibitors.
John Wityak, Kevin F McGee, Michael P Conlon, Ren Hua Song, Bryan C Duffy, Douglas B Kitchen

J Med Chem· April 2015

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Design, synthesis, and evaluation of nonretinoid retinol binding protein 4 antagonists for the potential treatment of atrophic age-related macular degeneration and Stargardt disease.
Christopher L Cioffi, Nicoleta Dobri, Emily E Freeman, Michael P Conlon, Ping Chen, Douglas B Kitchen

J Med Chem· September 2014

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The design and synthesis of novel SGLT2 inhibitors: C-glycosides with benzyltriazolopyridinone and phenylhydantoin as the aglycone moieties.
Cheng Guo, Min Hu, Russell J DeOrazio, Alexander Usyatinsky, Kevin Fitzpatrick, Douglas B Kitchen

Bioorg Med Chem· July 2014

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4-Phenyl tetrahydroisoquinolines as dual norepinephrine and dopamine reuptake inhibitors.
Anthony D Pechulis, James P Beck, Matt A Curry, Mark A Wolf, Arthur E Harms, Douglas B Kitchen

Bioorg Med Chem Lett· December 2012

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Early phase drug discovery: cheminformatics and computational techniques in identifying lead series.
Bryan C Duffy, Lei Zhu, Hélène Decornez, Douglas B Kitchen

Bioorg Med Chem· September 2012

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Design and synthesis of aryl ether and sulfone hydroxamic acids as potent histone deacetylase (HDAC) inhibitors.
Chittari Pabba, Brian T Gregg, Douglas B Kitchen, Zhen Jia Chen, Angela Judkins

Bioorg Med Chem Lett· January 2011

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5-Functionalized indazoles as glucocorticoid receptor agonists.
Mei Bai, Grant Carr, Russell J Deorazio, Thomas D Friedrich, Svetlana Dobritsa, Douglas B Kitchen

Bioorg Med Chem Lett· May 2010

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Design, selection, and evaluation of a general kinase-focused library.
Hélène Decornez, Anna Gulyás-Forró, Akos Papp, Miklós Szabó, Gabriella Sármay, Douglas B Kitchen

ChemMedChem· August 2009

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Computational approaches for modeling human intestinal absorption and permeability.
Govindan Subramanian, Douglas B Kitchen

J Mol Model· July 2006

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Docking and scoring in virtual screening for drug discovery: methods and applications.
Douglas B Kitchen, Hélène Decornez, John R Furr, Jürgen Bajorath

Nat Rev Drug Discov· November 2004

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Computational models to predict blood-brain barrier permeation and CNS activity.
Govindan Subramanian, Douglas B Kitchen

J Comput Aided Mol Des· October 2003

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Median Partitioning: a novel method for the selection of representative subsets from large compound pools.
Jeffrey W Godden, Ling Xue, Douglas B Kitchen, Florence L Stahura, E James Schermerhorn

J Chem Inf Comput Sci· September 2002

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