Publications by authors named "Douglas Chapin"

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Cross-site strain comparison of pharmacological deficits in the touchscreen visual discrimination test.
Eric G Mohler, Zhiyong Ding, Lynne E Rueter, Douglas Chapin, Damon Young

Psychopharmacology (Berl)· November 2015

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Reduction of brain kynurenic acid improves cognitive function.
Rouba Kozak, Brian M Campbell, Christine A Strick, Weldon Horner, William E Hoffmann, Douglas S Chapin

J Neurosci· August 2014

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Phosphodiesterase 9A regulates central cGMP and modulates responses to cholinergic and monoaminergic perturbation in vivo.
Robin J Kleiman, Douglas S Chapin, Curt Christoffersen, Jody Freeman, Kari R Fonseca

J Pharmacol Exp Ther· May 2012

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Use of structure-based design to discover a potent, selective, in vivo active phosphodiesterase 10A inhibitor lead series for the treatment of schizophrenia.
Christopher J Helal, Zhijun Kang, Xinjun Hou, Jayvardhan Pandit, Thomas A Chappie, Douglas S Chapin

J Med Chem· July 2011

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Discovery of a novel class of phosphodiesterase 10A inhibitors and identification of clinical candidate 2-[4-(1-methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-phenoxymethyl]-quinoline (PF-2545920) for the treatment of schizophrenia.
Patrick R Verhoest, Douglas S Chapin, Michael Corman, Kari Fonseca, John F Harms

J Med Chem· August 2009

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Behavioral and neurochemical characterization of mice deficient in the phosphodiesterase-4B (PDE4B) enzyme.
Judith A Siuciak, Sheryl A McCarthy, Douglas S Chapin, Ashley N Martin

Psychopharmacology (Berl)· March 2008

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Behavioral characterization of mice deficient in the phosphodiesterase-10A (PDE10A) enzyme on a C57/Bl6N congenic background.
Judith A Siuciak, Sheryl A McCarthy, Douglas S Chapin, Ashley N Martin, John F Harms

Neuropharmacology· February 2008

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Antipsychotic profile of rolipram: efficacy in rats and reduced sensitivity in mice deficient in the phosphodiesterase-4B (PDE4B) enzyme.
Judith A Siuciak, Douglas S Chapin, Sheryl A McCarthy, Ashley N Martin

Psychopharmacology (Berl)· June 2007

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CP-809,101, a selective 5-HT2C agonist, shows activity in animal models of antipsychotic activity.
Judith A Siuciak, Douglas S Chapin, Sheryl A McCarthy, Victor Guanowsky, Janice Brown

Neuropharmacology· February 2007

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Genetic deletion of the striatum-enriched phosphodiesterase PDE10A: evidence for altered striatal function.
Judith A Siuciak, Sheryl A McCarthy, Douglas S Chapin, Remie A Fujiwara, Larry C James

Neuropharmacology· August 2006

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Inhibition of the striatum-enriched phosphodiesterase PDE10A: a novel approach to the treatment of psychosis.
Judith A Siuciak, Douglas S Chapin, John F Harms, Lorraine A Lebel, Sheryl A McCarthy

Neuropharmacology· August 2006

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Pharmacology of selective acetylcholinesterase inhibitors: implications for use in Alzheimer's disease.
Dane R Liston, Jann A Nielsen, Anabella Villalobos, Douglas Chapin, Shawn B Jones

Eur J Pharmacol· February 2004

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Nuclear safety. Nuclear power plants and their fuel as terrorist targets.
Douglas M Chapin, Karl P Cohen, W Kenneth Davis, Edwin E Kintner, Leonard J Koch

Science· September 2002

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