Publications by authors named "Douglas Linn"

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Toward a CRISPR-based mouse model of -deficient clear cell kidney cancer: Initial experience and lessons learned.
Laura A Stransky, Wenhua Gao, Laura S Schmidt, Kevin Bi, Christopher J Ricketts, Douglas E Linn

Proc Natl Acad Sci U S A· October 2024

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Single-Cell Analysis Identifies NOTCH3-Mediated Interactions between Stromal Cells That Promote Microenvironment Remodeling and Invasion in Lung Adenocarcinoma.
Handan Xiang, Yidan Pan, Marc A Sze, Marta Wlodarska, Ling Li, Douglas E Linn

Cancer Res· May 2024

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Interplay of IGF1R and estrogen signaling regulates hematopoietic stem and progenitor cells.
Ying Xie, Dongxi Xiang, Xin Hu, Hubert Pakula, Eun-Sil Park, Douglas E Linn

bioRxiv· March 2024

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Reverse Translating Molecular Determinants of Anti-Programmed Death 1 Immunotherapy Response in Mouse Syngeneic Tumor Models.
Peter Georgiev, Eric S Muise, Douglas E Linn, Marlene C Hinton, Yun Wang

Mol Cancer Ther· March 2022

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A capillary electrophoresis based approach for the identification of anti-drug antibodies against camelid VHH biologics (Nanobodies®).
Derek Wiswell, Divas Neupane, Minchao Chen, Edward P Bowman, Douglas Linn

J Pharmacol Toxicol Methods· February 2021

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Protocols for Studies on TMPRSS2/ERG in Prostate Cancer.
Hubert Pakula, Douglas E Linn, Daniel R Schmidt, Marit Van Gorsel, Matthew G Vander Heiden

Methods Mol Biol· February 2019

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Single-Cell Analysis Identifies LY6D as a Marker Linking Castration-Resistant Prostate Luminal Cells to Prostate Progenitors and Cancer.
João D Barros-Silva, Douglas E Linn, Ivana Steiner, Guoji Guo, Adnan Ali

Cell Rep· December 2018

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Deletion of Interstitial Genes between TMPRSS2 and ERG Promotes Prostate Cancer Progression.
Douglas E Linn, Kathryn L Penney, Roderick T Bronson, Lorelei A Mucci, Zhe Li

Cancer Res· April 2016

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Genetic interaction between Tmprss2-ERG gene fusion and Nkx3.1-loss does not enhance prostate tumorigenesis in mouse models.
Douglas E Linn, Roderick T Bronson, Zhe Li

PLoS One· December 2015

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Pim-1 kinase phosphorylates and stabilizes 130 kDa FLT3 and promotes aberrant STAT5 signaling in acute myeloid leukemia with FLT3 internal tandem duplication.
Karthika Natarajan, Yingqiu Xie, Mehmet Burcu, Douglas E Linn, Yun Qiu

PLoS One· July 2014

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ETV1 directs androgen metabolism and confers aggressive prostate cancer in targeted mice and patients.
Esther Baena, Zhen Shao, Douglas E Linn, Kimberly Glass, Melanie J Hamblen

Genes Dev· March 2013

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Differential regulation of androgen receptor by PIM-1 kinases via phosphorylation-dependent recruitment of distinct ubiquitin E3 ligases.
Douglas E Linn, Xi Yang, Yingqiu Xie, Alan Alfano, Dhanraj Deshmukh

J Biol Chem· June 2012

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A Role for OCT4 in Tumor Initiation of Drug-Resistant Prostate Cancer Cells.
Douglas E Linn, Xi Yang, Feng Sun, Yingqiu Xie, Hege Chen

Genes Cancer· September 2010

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Pim-1 kinase protects P-glycoprotein from degradation and enables its glycosylation and cell surface expression.
Yingqiu Xie, Mehmet Burcu, Douglas E Linn, Yun Qiu, Maria R Baer

Mol Pharmacol· August 2010

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Compensatory upregulation of tyrosine kinase Etk/BMX in response to androgen deprivation promotes castration-resistant growth of prostate cancer cells.
Bojie Dai, Hege Chen, Shengjie Guo, Xi Yang, Douglas E Linn

Cancer Res· July 2010

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Regulation of androgen receptor transcriptional activity and specificity by RNF6-induced ubiquitination.
Kexin Xu, Hermela Shimelis, Douglas E Linn, Richeng Jiang, Xi Yang

Cancer Cell· April 2009

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A novel androgen receptor splice variant is up-regulated during prostate cancer progression and promotes androgen depletion-resistant growth.
Zhiyong Guo, Xi Yang, Feng Sun, Richeng Jiang, Douglas E Linn

Cancer Res· March 2009

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EBP1, an ErbB3-binding protein, is decreased in prostate cancer and implicated in hormone resistance.
Yuexing Zhang, Douglas Linn, Zhenqiu Liu, Jonathan Melamed, Fabio Tavora

Mol Cancer Ther· October 2008

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The 44-kDa Pim-1 kinase phosphorylates BCRP/ABCG2 and thereby promotes its multimerization and drug-resistant activity in human prostate cancer cells.
Yingqiu Xie, Kexin Xu, Douglas E Linn, Xi Yang, Zhiyong Guo

J Biol Chem· February 2008

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