Publications by authors named "Douwe Samplonius"

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CD19-ReTARG: A Novel Fusion Protein for Physiological Engagement of Anti-CMV Cytotoxic T Cells Against CD19-Expressing Malignancies.
Anne Paulien van Wijngaarden, Isabel Britsch, Matthias Peipp, Douwe Freerk Samplonius, Wijnand Helfrich

Cancers (Basel)· July 2025

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Enhancing the Anticancer Activity of a Carcinoma-Directed Peptide-HLA-I Fusion Protein by Armoring with Mutein IFNα.
Douwe Freerk Samplonius, Anne Paulien van Wijngaarden, Lisanne Koll, Xiurong Ke, Wijnand Helfrich

Int J Mol Sci· March 2025

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Visible Light Control over the Cytolytic Activity of a Toxic Pore-Forming Protein.
Jana Volarić, Nieck J van der Heide, Natalie L Mutter, Douwe F Samplonius, Wijnand Helfrich

ACS Chem Biol· February 2024

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Bispecific antibody CD73xEGFR more selectively inhibits the CD73/adenosine immune checkpoint on cancer cells and concurrently counteracts pro-oncogenic activities of CD73 and EGFR.
Emily Maria Ploeg, Douwe Freerk Samplonius, Xiao Xiong, Xiurong Ke, Mark Alexander Johannes Martinus Hendriks

J Immunother Cancer· September 2023

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A Novel Bispecific Antibody for EpCAM-Directed Inhibition of the CD73/Adenosine Immune Checkpoint in Ovarian Cancer.
Emily Maria Ploeg, Isabel Britsch, Anne Paulien van Wijngaarden, Xiurong Ke, Mark Alexander Johannes Martinus Hendriks, Douwe Freerk Samplonius

Cancers (Basel)· July 2023

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Novel Fab-peptide-HLA-I fusion proteins for redirecting pre-existing anti-CMV T cell immunity to selective eliminate carcinoma cells.
Isabel Britsch, Anne P van Wijngaarden, Xiurong Ke, Mark A J M Hendriks, Douwe F Samplonius

Oncoimmunology· May 2023

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A proof-of-concept study on the use of a fluorescein-based F-tracer for pretargeted PET.
Hugo Helbert, Emily M Ploeg, Douwe F Samplonius, Simon N Blok, Ines F Antunes

EJNMMI Radiopharm Chem· March 2022

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Cancer cells under immune attack acquire CD47-mediated adaptive immune resistance independent of the myeloid CD47-SIRPα axis.
Mark A J M Hendriks, Isabel Britsch, Xiurong Ke, Anne P van Wijngarden, Douwe F Samplonius

Oncoimmunology· January 2022

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Bispecific antibody CD73xEpCAM selectively inhibits the adenosine-mediated immunosuppressive activity of carcinoma-derived extracellular vesicles.
Emily M Ploeg, Xiurong Ke, Isabel Britsch, Mark A J M Hendriks, Femke A Van der Zant, Douwe F Samplonius

Cancer Lett· November 2021

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Synthesis and Evaluation of F-Enzalutamide, a New Radioligand for PET Imaging of Androgen Receptors: A Comparison with 16β-F-Fluoro-5α-Dihydrotestosterone.
Inês F Antunes, Rutger J Dost, Hilde D Hoving, Aren van Waarde, Rudi A J O Dierckx, Douwe F Samplonius

J Nucl Med· August 2021

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Corrigendum: Modular Medical Imaging Agents Based on Azide-Alkyne Huisgen Cycloadditions: Synthesis and Pre-Clinical Evaluation of 18F-Labeled PSMA-Tracers for Prostate Cancer Imaging.
Verena I Böhmer, Wiktor Szymanski, Keimpe-Oeds van den Berg, Chantal Mulder, Piermichele Kobauri, Douwe F Samplonius

Chemistry· April 2021

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Bispecific antibody approach for EGFR-directed blockade of the CD47-SIRPα "don't eat me" immune checkpoint promotes neutrophil-mediated trogoptosis and enhances antigen cross-presentation.
Mark A J M Hendriks, Emily M Ploeg, Iris Koopmans, Isabel Britsch, Xiurong Ke, Douwe F Samplonius

Oncoimmunology· September 2020

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Modular Medical Imaging Agents Based on Azide-Alkyne Huisgen Cycloadditions: Synthesis and Pre-Clinical Evaluation of F-Labeled PSMA-Tracers for Prostate Cancer Imaging.
Verena I Böhmer, Wiktor Szymanski, Keimpe-Oeds van den Berg, Chantal Mulder, Piermichele Kobauri, Douwe F Samplonius

Chemistry· August 2020

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Bispecific Antibody Approach for Improved Melanoma-Selective PD-L1 Immune Checkpoint Blockade.
Iris Koopmans, Mark A J M Hendriks, Robert J van Ginkel, Douwe F Samplonius, Edwin Bremer

J Invest Dermatol· November 2019

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Quantitative proteomics analysis identifies MUC1 as an effect sensor of EGFR inhibition.
H Rudolf de Boer, Martin Pool, Esméé Joosten, Marieke Everts, Douwe F Samplonius

Oncogene· February 2019

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A novel bispecific antibody for EGFR-directed blockade of the PD-1/PD-L1 immune checkpoint.
Iris Koopmans, Djoke Hendriks, Douwe F Samplonius, Robert J van Ginkel, Sandra Heskamp

Oncoimmunology· May 2018

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A versatile pretargeting approach for tumour-selective delivery and activation of TNF superfamily members.
Yuan He, Peter E van Bommel, Douwe F Samplonius, Edwin Bremer, Wijnand Helfrich

Sci Rep· October 2017

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CD20-selective inhibition of CD47-SIRPα "don't eat me" signaling with a bispecific antibody-derivative enhances the anticancer activity of daratumumab, alemtuzumab and obinutuzumab.
Peter E van Bommel, Yuan He, Ilona Schepel, Mark A J M Hendriks, Valerie R Wiersma, Douwe F Samplonius

Oncoimmunology· October 2017

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CD103+ intraepithelial T cells in high-grade serous ovarian cancer are phenotypically diverse TCRαβ+ CD8αβ+ T cells that can be targeted for cancer immunotherapy.
Fenne L Komdeur, Maartje C A Wouters, Hagma H Workel, Aline M Tijans, Anouk L J Terwindt, Douwe F Samplonius

Oncotarget· November 2016

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Programmed Death Ligand 1 (PD-L1)-targeted TRAIL combines PD-L1-mediated checkpoint inhibition with TRAIL-mediated apoptosis induction.
Djoke Hendriks, Yuan He, Iris Koopmans, Valerie R Wiersma, Robert J van Ginkel, Douwe F Samplonius

Oncoimmunology· August 2016

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The epithelial polarity regulator LGALS9/galectin-9 induces fatal frustrated autophagy in KRAS mutant colon carcinoma that depends on elevated basal autophagic flux.
Valerie R Wiersma, Marco de Bruyn, Yunwei Wei, Robert J van Ginkel, Mitsuomi Hirashima, Douwe F Samplonius

Autophagy· June 2016

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Melanoma-Directed Activation of Apoptosis Using a Bispecific Antibody Directed at MCSP and TRAIL Receptor-2/Death Receptor-5.
Yuan He, Djoke Hendriks, Robert van Ginkel, Douwe Samplonius, Edwin Bremer

J Invest Dermatol· February 2016

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C-type lectin-like molecule-1 (CLL1)-targeted TRAIL augments the tumoricidal activity of granulocytes and potentiates therapeutic antibody-dependent cell-mediated cytotoxicity.
Valerie R Wiersma, Marco de Bruyn, Ce Shi, Marloes J M Gooden, Maartje C A Wouters, Douwe F Samplonius

MAbs· November 2015

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CD20 T cells have a predominantly Tc1 effector memory phenotype and are expanded in the ascites of patients with ovarian cancer.
Marco de Bruyn, Valerie R Wiersma, Maartje C A Wouters, Douwe F Samplonius, Harry G Klip

Oncoimmunology· April 2015

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Photochemical internalization (PCI)-mediated enhancement of bleomycin cytotoxicity by liposomal mTHPC formulations in human head and neck cancer cells.
Wei Peng, Douwe F Samplonius, Sebastiaan de Visscher, Jan L N Roodenburg, Wijnand Helfrich

Lasers Surg Med· October 2014

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