Publications by authors named "Dow Hurst"

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The NPXXY Motif Regulates β-Arrestin Recruitment by the CB1 Cannabinoid Receptor.
Luciana M Leo, Rufaida Al-Zoubi, Dow P Hurst, Anna P Stephan, Pingwei Zhao

Cannabis Cannabinoid Res· October 2023

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Design, synthesis, and evaluation of substituted alkylindoles that activate G protein-coupled receptors distinct from the cannabinoid CB and CB receptors.
Toni Kline, Cong Xu, Faith R Kreitzer, Dow P Hurst, Khalil M Eldeeb

Eur J Med Chem· March 2023

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Thienopyrimidine Derivatives as GPR55 Receptor Antagonists: Insight into Structure-Activity Relationship.
Laura Figuerola-Asencio, Paula Morales, Pingwei Zhao, Dow P Hurst, Sommayah S Sayed

ACS Med Chem Lett· January 2023

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Pharmacological evaluation of enantiomerically separated positive allosteric modulators of cannabinoid 1 receptor, GAT591 and GAT593.
Asher L Brandt, Sumanta Garai, Ayat Zagzoog, Dow P Hurst, Lesley A Stevenson

Front Pharmacol· October 2022

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TRPV1 Activation by Anandamide via a Unique Lipid Pathway.
Chanté Muller, Diane L Lynch, Dow P Hurst, Patricia H Reggio

J Chem Inf Model· December 2021

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Discovery of a Biased Allosteric Modulator for Cannabinoid 1 Receptor: Preclinical Anti-Glaucoma Efficacy.
Sumanta Garai, Luciana M Leo, Anna-Maria Szczesniak, Dow P Hurst, Peter C Schaffer

J Med Chem· June 2021

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Therapeutic Exploitation of GPR18: Beyond the Cannabinoids?
Paula Morales, Ana Lago-Fernandez, Dow P Hurst, Noori Sotudeh, Eugen Brailoiu

J Med Chem· December 2020

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A Closer Look at Anandamide Interaction With TRPV1.
Chante Muller, Diane L Lynch, Dow P Hurst, Patricia H Reggio

Front Mol Biosci· July 2020

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GPR6 Structural Insights: Homology Model Construction and Docking Studies.
Israa H Isawi, Paula Morales, Noori Sotudeh, Dow P Hurst, Diane L Lynch

Molecules· February 2020

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The Nucleotide-Free State of the Cannabinoid CB2/Gi Complex.
Diane L Lynch, Dow P Hurst, Patricia H Reggio

Cell· February 2020

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Application of Fluorine- and Nitrogen-Walk Approaches: Defining the Structural and Functional Diversity of 2-Phenylindole Class of Cannabinoid 1 Receptor Positive Allosteric Modulators.
Sumanta Garai, Pushkar M Kulkarni, Peter C Schaffer, Luciana M Leo, Asher L Brandt, Dow P Hurst

J Med Chem· January 2020

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Identification of CB1 Receptor Allosteric Sites Using Force-Biased MMC Simulated Annealing and Validation by Structure-Activity Relationship Studies.
Dow P Hurst, Sumanta Garai, Pushkar M Kulkarni, Peter C Schaffer, Patricia H Reggio

ACS Med Chem Lett· August 2019

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Towards A Molecular Understanding of The Cannabinoid Related Orphan Receptor GPR18: A Focus on Its Constitutive Activity.
Noori Sotudeh, Paula Morales, Dow P Hurst, Diane L Lynch, Patricia H Reggio

Int J Mol Sci· May 2019

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Up in Smoke: Uncovering a Lack of Evidence for Proton Pump Inhibitors as a Source of Tetrahydrocannabinol Immunoassay False Positives.
Jennifer L Powers, Natalie N Rasmussen, Dow Hurst, Frederick G Strathmann

Pain Med· November 2018

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( R)- N-(1-Methyl-2-hydroxyethyl)-13-( S)-methyl-arachidonamide (AMG315): A Novel Chiral Potent Endocannabinoid Ligand with Stability to Metabolizing Enzymes.
Yingpeng Liu, Lipin Ji, Marsha Eno, Shalley Kudalkar, Ai-Ling Li, Dow Hurst

J Med Chem· October 2018

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Synthesis, Pharmacological Evaluation, and Docking Studies of Novel Pyridazinone-Based Cannabinoid Receptor Type 2 Ligands.
Giulio Ragusa, Serena Bencivenni, Paula Morales, Tyra Callaway, Dow P Hurst

ChemMedChem· June 2018

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Methods for the Development of In Silico GPCR Models.
Paula Morales, Dow P Hurst, Patricia H Reggio

Methods Enzymol· April 2018

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Molecular Dynamics Methodologies for Probing Cannabinoid Ligand/Receptor Interaction.
Diane L Lynch, Dow P Hurst, Derek M Shore, Mike C Pitman, Patricia H Reggio

Methods Enzymol· April 2018

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Design, synthesis and biological evaluation of GPR55 agonists.
Lara Fakhouri, Christopher D Cook, Mohammed H Al-Huniti, Linda M Console-Bram, Dow P Hurst

Bioorg Med Chem· August 2017

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Molecular Targets of the Phytocannabinoids: A Complex Picture.
Paula Morales, Dow P Hurst, Patricia H Reggio

Prog Chem Org Nat Prod· June 2017

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A dual substrate kinetic model for cytochrome P450-F87G catalysis: simultaneous binding of long chain aldehydes and 4-fluorophenol.
Chelsea Ledford, Monica McMahon, Ashley Whitesell, Ghalib Khan, Suneel K Kandagatla, Dow P Hurst

Biotechnol Lett· February 2017

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Structure-activity relationships of benzothiazole GPR35 antagonists.
Manahil M Abdalhameed, Pingwei Zhao, Dow P Hurst, Patricia H Reggio, Mary E Abood

Bioorg Med Chem Lett· February 2017

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Identification of Crucial Amino Acid Residues Involved in Agonist Signaling at the GPR55 Receptor.
Mary A Lingerfelt, Pingwei Zhao, Haleli P Sharir, Dow P Hurst, Patricia H Reggio

Biochemistry· January 2017

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Chromenopyrazole, a Versatile Cannabinoid Scaffold with in Vivo Activity in a Model of Multiple Sclerosis.
Paula Morales, María Gómez-Cañas, Gemma Navarro, Dow P Hurst, Francisco J Carrillo-Salinas

J Med Chem· July 2016

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Mapping Cannabinoid 1 Receptor Allosteric Site(s): Critical Molecular Determinant and Signaling Profile of GAT100, a Novel, Potent, and Irreversibly Binding Probe.
Robert B Laprairie, Abhijit R Kulkarni, Pushkar M Kulkarni, Dow P Hurst, Diane Lynch

ACS Chem Neurosci· June 2016

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