Publications by authors named "Du Guangying"

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Synthesis and evaluation of novel 5-HT receptor inverse agonist with excellent in vivo antipsychotic efficacy and superior tissue distribution for treatment of Parkinson's disease psychosis.
Mingxu Ma, Guangying Du, Wenyan Wang, Yusen Dai, Hengwei Xu

Eur J Med Chem· November 2025

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Design, synthesis, and biological evaluation of novel molecules as potent inhibitors of indoleamine 2,3-dioxygenase 1.
Shujuan Wei, Fuao Zhang, Wenyan Wang, Guangying Du, Pengfei Yu

Mol Divers· October 2025

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Pharmacodynamics, safety pharmacology and local tolerance of rotigotine behenate extended-release microspheres.
Yumeng Chen, Zhicong Yin, Caiyi Qin, Mengting Wu, Wenjing Lv, Guangying Du

Toxicol Appl Pharmacol· October 2025

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Machine learning and network toxicology reveal arsenic as a key driver of non-carcinogenic health risks from heavy metal residues in Chinese medicinal plants.
Guangying Du, Yuanju Zhang, Ting Zou, Chang Liu, Yingyue Hou

Sci Total Environ· September 2025

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Global research trends in tryptophan metabolism and cancer: a bibliometric and visualization analysis (2005-2024).
Huanhuan Ma, Ran Ding, Junwen Wang, Guangying Du, Yun Zhang

Front Oncol· July 2025

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Seasonal Variations in Sugar Accumulation Patterns of Dendrobium officinale: Integrated Analysis via Machine Learning, Physiology, and Transcriptomics.
Jing Li, Yuanju Zhang, Yingyue Hou, Rong Zhou, Yang Lu, Guangying Du

Physiol Plant· June 2025

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Multidimensional evaluation of quality differences for stems grown under different cultivation environments based on widely targeted metabolomics, network pharmacology, molecular docking, and cell experiments.
Yingyue Hou, Guangying Du, Jing Li, Pei Liu, Jinqiang Zhang

Front Plant Sci· March 2025

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Design, synthesis, and biological evaluation of novel molecules as potent inhibitors of PLK1.
Jing Lu, Hui Lei, Xinfa Bai, Wenyan Wang, Chunjiao Liu, Guangying Du

Bioorg Chem· October 2023

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Non-clinical pharmacology and toxicology studies of LPM6690061, a novel 5-hydroxytryptamine (5-HT) receptor inverse agonist.
Xiaoyin Zhu, Yue Yang, Guangying Du, Bin Liu, Xin Yu

Food Chem Toxicol· June 2023

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Use of Microscopic Characteristics and Multielemental Fingerprinting Analysis to Trace Three Different Cultivation Modes of Medicinal and Edible Dendrobium officinale in China.
Guangying Du, Ruidong Yang, Fulin Yan, Shenghua Wei, Deqiang Ren

Biol Trace Elem Res· February 2023

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Pharmacological and toxicological studies of a novel goserelin acetate extended-release microspheres in rats.
Mao Yutong, Ye Liang, Sha Chunjie, Guan Xiaolin, Gong Xiaoyan, Du Guangying

Front Pharmacol· February 2023

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Biparatopic antibody BA7208/7125 effectively neutralizes SARS-CoV-2 variants including Omicron BA.1-BA.5.
Yanqun Wang, An Yan, Deyong Song, Chuangchuang Dong, Muding Rao, Guangying Du

Cell Discov· January 2023

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Non-clinical pharmacology and toxicology studies of bevacizumab biosimilar LY01008.
Du Guangying, Ma Shuzhi, Zhu Xiaoyin, Yu Pengfei, Yu Xin

Eur J Pharmacol· December 2022

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9-Cyclopropylmethoxy-dihydrotetrabenazine and its stereoisomers as vesicular monoamine transporter-2 inhibitors.
Wenyan Wang, Shilan Lin, Guangying Du, Xinfa Bai, Jing Lu

Future Med Chem· July 2022

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Improving the treatment of Parkinson's disease: Structure-based development of novel 5-HT receptor antagonists/inverse agonists.
Mingxu Ma, Yifei Yang, Guangying Du, Yusen Dai, Xiaoyin Zhu

Eur J Med Chem· April 2022

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(+)-9-Trifluoroethoxy-α-Dihydrotetrabenazine as a Highly Potent Vesicular Monoamine Transporter 2 Inhibitor for Tardive Dyskinesia.
Wenyan Wang, Guangying Du, Shilan Lin, Jing Liu, Huijie Yang

Front Pharmacol· December 2021

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Synthesis and analysis of dihydrotetrabenazine derivatives as novel vesicular monoamine transporter 2 inhibitors.
Yifei Yang, Dawei Yu, Xiaoyin Zhu, Guangying Du, Wenyan Wang

Eur J Med Chem· November 2021

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Comparison study of different indoleamine-2,3 dioxygenase inhibitors from the perspective of pharmacodynamic effects.
Xue Jiang, Xiaopeng Li, Shuang Zheng, Guangying Du, Jinbo Ma

Int J Immunopathol Pharmacol· July 2021

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Structure and function analysis of a potent human neutralizing antibody CA521 against SARS-CoV-2.
Deyong Song, Wenbo Wang, Chuangchuang Dong, Zhenfei Ning, Xiu Liu, Guangying Du

Commun Biol· April 2021

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PCC0208009, an indirect IDO1 inhibitor, alleviates neuropathic pain and co-morbidities by regulating synaptic plasticity of ACC and amygdala.
Yu Wang, Chun-Mei Li, Rui Han, Zhe-Zhe Wang, Yong-Lin Gao

Biochem Pharmacol· July 2020

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PCC0208023, a potent SHP2 allosteric inhibitor, imparts an antitumor effect against KRAS mutant colorectal cancer.
Xiao Chen, Fangxia Zou, Zhengping Hu, Guangying Du, Pengfei Yu

Toxicol Appl Pharmacol· July 2020

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PCC0208025 (BMS202), a small molecule inhibitor of PD-L1, produces an antitumor effect in B16-F10 melanoma-bearing mice.
Zhengping Hu, Pengfei Yu, Guangying Du, Wenyan Wang, Haibo Zhu

PLoS One· June 2020

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Pharmacokinetics of S-EPA, and its inhibition on indoleamine 2,3-dioxgenase: a case of sulfur-substitution affecting distributions in blood cells.
Wenyan Wang, Xuhui Zhuang, Heyuan Sun, Lina Dong, Zongliang Liu, Guangying Du

Xenobiotica· November 2019

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PCC0208018 exerts antitumor effects by activating effector T cells.
Minmin Ge, Zhengping Hu, Xiao Chen, Guangying Du, Hongbo Wang

Int J Immunopathol Pharmacol· July 2019

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Determination of kynurnine and tryptophan, biomarkers of indoleamine 2,3-dioxygenase by LC-MS/MS in plasma and tumor.
Wenyan Wang, Xuhui Zhuang, Wenrong Liu, Lina Dong, Heyuan Sun, Guangying Du

Bioanalysis· August 2018

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