Publications by authors named "Duncan Jodrell"

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Transcription factor switching drives subtype-specific pancreatic cancer.
Shalini V Rao, Lisa Young, Danya Cheeseman, Sean Flynn, Niklas Krebs, Duncan Jodrell

Nat Genet· December 2025

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First-in-Human Study to Evaluate the Safety and Efficacy of Anti-GDF15 Antibody AZD8853 in Patients with Advanced/Metastatic Solid Tumors.
Benedito A Carneiro, Olumide B Gbolahan, Albiruni Abdul Abdul Razak, John F Hilton, Arthur W Lambert, Duncan I Jodrell

Cancer Res Commun· June 2025

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Intratumoral antigen signaling traps CD8 T cells to confine exhaustion to the tumor site.
Munetomo Takahashi, Tsz Y So, Vitalina Chamberlain-Evans, Robert Hughes, Juan Carlos Yam-Puc, Duncan I Jodrell

Sci Immunol· May 2024

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Defining the spatial distribution of extracellular adenosine revealed a myeloid-dependent immunosuppressive microenvironment in pancreatic ductal adenocarcinoma.
Vincenzo Graziano, Andreas Dannhorn, Heather Hulme, Kate Williamson, Hannah Buckley, Duncan I Jodrell

J Immunother Cancer· August 2023

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Clinical and biological markers predictive of treatment response associated with metastatic pancreatic adenocarcinoma.
Alimu Dayimu, Lorena Di Lisio, Shubha Anand, Isart Roca-Carreras, Wendi Qian, Duncan Jodrell

Br J Cancer· May 2023

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Size-tuneable and immunocompatible polymer nanocarriers for drug delivery in pancreatic cancer.
Andrea Bistrović Popov, Francesca Melle, Emily Linnane, Cristina González-López, Ishtiaq Ahmed, Duncan I Jodrell

Nanoscale· May 2022

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Early Neutrophilia Marked by Aerobic Glycolysis Sustains Host Metabolism and Delays Cancer Cachexia.
Michele Petruzzelli, Miriam Ferrer, Martijn J Schuijs, Sam O Kleeman, Nicholas Mourikis, Duncan I Jodrell

Cancers (Basel)· February 2022

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Method To Visualize the Intratumor Distribution and Impact of Gemcitabine in Pancreatic Ductal Adenocarcinoma by Multimodal Imaging.
Nicole Strittmatter, Frances M Richards, Alan M Race, Stephanie Ling, Daniel Sutton, Duncan I Jodrell

Anal Chem· January 2022

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T Cell-Mediated Antitumor Immunity Cooperatively Induced By TGFβR1 Antagonism and Gemcitabine Counteracts Reformation of the Stromal Barrier in Pancreatic Cancer.
Dandan Li, Nicholas Schaub, Theresa M Guerin, Tashinga E Bapiro, Frances M Richards, Duncan I Jodrell

Mol Cancer Ther· October 2021

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Quantifying cell cycle-dependent drug sensitivities in cancer using a high throughput synchronisation and screening approach.
Timothy I Johnson, Christopher J Minteer, Daniel Kottmann, Charles R Dunlop, Sandra Bernaldo de Quirós Fernández, Duncan I Jodrell

EBioMedicine· June 2021

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Mechanisms Underlying Vascular Endothelial Growth Factor Receptor Inhibition-Induced Hypertension: The HYPAZ Trial.
Kaisa M Mäki-Petäjä, Adam McGeoch, Lucy L Yang, Annette Hubsch, Carmel M McEniery, Duncan I Jodrell

Hypertension· May 2021

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CXCR4 inhibition in human pancreatic and colorectal cancers induces an integrated immune response.
Daniele Biasci, Martin Smoragiewicz, Claire M Connell, Zhikai Wang, Ya Gao, Duncan I Jodrell

Proc Natl Acad Sci U S A· November 2020

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Complete loss of ATM function augments replication catastrophe induced by ATR inhibition and gemcitabine in pancreatic cancer models.
Charles R Dunlop, Yann Wallez, Timothy Isaac Johnson, Sandra Bernaldo de Quirós Fernández, Stephen T Durant, Duncan I Jodrell

Br J Cancer· October 2020

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Opportunities for Quantitative Translational Modeling in Oncology.
James W T Yates, Helen Byrne, Sonya C Chapman, Tao Chen, Lourdes Cucurull-Sanchez, Duncan Jodrell

Clin Pharmacol Ther· September 2020

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Depletion of Macrophages Improves Therapeutic Response to Gemcitabine in Murine Pancreas Cancer.
Soeren M Buchholz, Robert G Goetze, Shiv K Singh, Christoph Ammer-Herrmenau, Frances M Richards, Duncan I Jodrell

Cancers (Basel)· July 2020

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Early relapse on adjuvant gemcitabine associated with an exceptional response to 2nd line capecitabine chemotherapy in a patient with pancreatic adenosquamous carcinoma with strong intra-tumoural expression of cytidine deaminase: a case report.
Claire M Connell, Rebecca Brais, Hayley Whitaker, Sara Upponi, Ian Beh, Duncan I Jodrell

BMC Cancer· January 2020

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Multicenter Validation of the CamGFR Model for Estimated Glomerular Filtration Rate.
Edward H Williams, Claire M Connell, James M J Weaver, Ian Beh, Harry Potts, Duncan Jodrell

JNCI Cancer Spectr· December 2019

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Identification of Resistance Pathways Specific to Malignancy Using Organoid Models of Pancreatic Cancer.
Mariano Ponz-Sarvise, Vincenzo Corbo, Hervé Tiriac, Dannielle D Engle, Kristopher K Frese, Duncan I Jodrell

Clin Cancer Res· November 2019

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Quantifying Drug-Induced Bone Marrow Toxicity Using a Novel Haematopoiesis Systems Pharmacology Model.
Chiara Fornari, Lenka Oplustil O'Connor, Carmen Pin, Aaron Smith, James W T Yates, Duncan I Jodrell

CPT Pharmacometrics Syst Pharmacol· November 2019

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Targeting melanoma's MCL1 bias unleashes the apoptotic potential of BRAF and ERK1/2 pathway inhibitors.
Matthew J Sale, Emma Minihane, Noel R Monks, Rebecca Gilley, Frances M Richards, Duncan I Jodrell

Nat Commun· November 2019

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SPARC dependent collagen deposition and gemcitabine delivery in a genetically engineered mouse model of pancreas cancer.
Iswarya Ramu, Sören M Buchholz, Melanie S Patzak, Robert G Goetze, Shiv K Singh, Duncan I Jodrell

EBioMedicine· October 2019

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Loss of the interleukin-6 receptor causes immunodeficiency, atopy, and abnormal inflammatory responses.
Sarah Spencer, Sevgi Köstel Bal, William Egner, Hana Lango Allen, Syed I Raza, Duncan Ian Jodrell

J Exp Med· September 2019

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Cytosolic 5'-nucleotidase 1A is overexpressed in pancreatic cancer and mediates gemcitabine resistance by reducing intracellular gemcitabine metabolites.
Melanie S Patzak, Vijayalakshmi Kari, Shilpa Patil, Feda H Hamdan, Robert G Goetze, Duncan I Jodrell

EBioMedicine· February 2019

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The ATR Inhibitor AZD6738 Synergizes with Gemcitabine and to Induce Pancreatic Ductal Adenocarcinoma Regression.
Yann Wallez, Charles R Dunlop, Timothy Isaac Johnson, Siang-Boon Koh, Chiara Fornari, Duncan I Jodrell

Mol Cancer Ther· August 2018

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Mechanistic Distinctions between CHK1 and WEE1 Inhibition Guide the Scheduling of Triple Therapy with Gemcitabine.
Siang-Boon Koh, Yann Wallez, Charles R Dunlop, Sandra Bernaldo de Quirós Fernández, Tashinga E Bapiro, Duncan I Jodrell

Cancer Res· June 2018

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