Publications by authors named "Dunming Zhu"

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Engineering Imine Reductase for the Synthesis of Pharmaceutically Relevant 1-Aminomethylbenzocycloalkanes via Dynamic Kinetic Resolution-Asymmetric Reductive Amination.
Xiaoshi Lv, Zefei Xu, Xiangtao Liu, Jinhui Feng, Hongkai Zhang, Dunming Zhu

Org Lett· December 2025

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Efficient Synthesis of Steroidal Intermediates with a C17 Side Chain from Phytosterols by Genetically Modified Mycolicibacterium neoaurum NRRL B-3805 Strain.
Xuemei Li, Liangyan Zhu, Qiong Wu, Rui Zhang, Yiyin Liu, Dunming Zhu

ChemistryOpen· September 2025

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Identification of Enoyl-CoA Hydratase EchA19 in Mycolicibacterium neoaurum Involved in the First β-Oxidation Pathway of Phytosterols for Key Steroidal Intermediate Synthesis.
Liangyan Zhu, Han Si, Xuemei Li, Na Liu, Jinhui Feng, Dunming Zhu

Appl Biochem Biotechnol· July 2025

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Enzymatic synthesis of four stereoisomers of 3-substituted-4-hydroxypiperidines by carbonyl reductase-catalyzed reduction.
Jing Chen, Xi Chen, Jinsong Song, Hongliu Zhang, Hongjiang Yang, Dunming Zhu

RSC Adv· June 2025

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Asymmetric Synthesis of -Hydroxyethyl Amino Indane Derivatives Catalyzed by an Engineered Imine Reductase.
Jinyang Li, Zefei Xu, Jinhui Feng, Shuhong Mao, Peiyuan Yao, Dunming Zhu

Org Lett· April 2025

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Discovery and directed evolution of C-C bond formation enzymes for the biosynthesis of β-hydroxy-α-amino acids and derivatives.
Qijia Chen, Jingmin Wang, Sisi Zhang, Xi Chen, Jianxiong Hao, Dunming Zhu

Crit Rev Biotechnol· December 2024

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[Research progress of the multifunctional oxidase scopolamine 6β-hydroxylase].
Xi Chen, Qiaqing Wu, Dunming Zhu

Sheng Wu Gong Cheng Xue Bao· September 2024

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Identification and structure-based engineering of a dipeptidase CpPepD from Clostridium perfringens for the synthesis of l-carnosine.
Xiaohan Zhang, Xiangtao Liu, Xi Chen, Jinhui Feng, Qing Zhao, Dunming Zhu

J Biotechnol· June 2024

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Engineered Imine Reductase for Asymmetric Synthesis of Dextromethorphan Key Intermediate.
Xiaofeng Lin, Yixuan Li, Zefei Xu, Shanshan Yu, Jinhui Feng, Dunming Zhu

Org Lett· May 2024

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Chemo-Enzymatic Strategy for the Efficient Synthesis of Steroidal Drugs with 10α-Methyl Group and a Side Chain at C17-Position from Biorenewable Phytosterols.
Xuemei Li, Rui Zhang, Jianjiong Li, Na Liu, Xi Chen, Dunming Zhu

JACS Au· April 2024

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Reshaping the Substrate Binding Pocket of β-Amino Acid Dehydrogenase for the Synthesis of Aromatic β-Amino Acids.
Na Liu, Jinhui Feng, Xi Chen, Yuyang Luo, Tong Lv, Dunming Zhu

Org Lett· December 2023

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Photoredox/Enzymatic Catalysis Enabling Redox-Neutral Decarboxylative Asymmetric C-C Coupling for Asymmetric Synthesis of Chiral 1,2-Amino Alcohols.
Yiyin Liu, Liangyan Zhu, Xuemei Li, Yunfeng Cui, Atefeh Roosta, Dunming Zhu

JACS Au· November 2023

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Semirational Engineering of a Thermostable Carbonyl Reductase for the Precision Synthesis of (2,3)-2-Methyl-2-benzyl-3-hydroxycyclopentanone and Its Analogues.
Liangyan Zhu, Xi Chen, Jinhui Feng, Yunfeng Cui, Qiaqing Wu, Dunming Zhu

J Org Chem· August 2023

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Enantiodivergent Synthesis of 1-Heteroaryl Tetrahydroisoquinolines Catalyzed by Imine Reductases.
Tingting Liu, Zefei Xu, Jinhui Feng, Shanshan Yu, Min Wang, Dunming Zhu

Org Lett· April 2023

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[Green biosynthesis of chiral pharmaceutical chemicals].
Xi Chen, Fengli Wu, Feiyu Fan, Qiaqing Wu, Dunming Zhu

Sheng Wu Gong Cheng Xue Bao· November 2022

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[Construction of strains for bioconversion of steroid key intermediates and intelligent industrial production].
Jinhui Feng, Rujin Zhang, Zhengbin Zhang, Qiaqing Wu, Dunming Zhu

Sheng Wu Gong Cheng Xue Bao· November 2022

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Asymmetric Synthesis of Fused-Ring Tetrahydroisoquinolines and Tetrahydro-β-carbolines from 2-Arylethylamines via a Chemoenzymatic Approach.
Linsong Yang, Jianjiong Li, Zefei Xu, Peiyuan Yao, Qiaqing Wu, Dunming Zhu

Org Lett· September 2022

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Biotransformation Enables Innovations Toward Green Synthesis of Steroidal Pharmaceuticals.
Jinhui Feng, Qiaqing Wu, Dunming Zhu, Yanhe Ma

ChemSusChem· May 2022

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Asymmetric Synthesis of N-Substituted 1,2-Amino Alcohols from Simple Aldehydes and Amines by One-Pot Sequential Enzymatic Hydroxymethylation and Asymmetric Reductive Amination.
Yu Li, Na Hu, Zefei Xu, Yunfeng Cui, Jinhui Feng, Dunming Zhu

Angew Chem Int Ed Engl· April 2022

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Engineering a Carbonyl Reductase for Scalable Preparation of (S)-3-Cyclopentyl-3-hydroxypropanenitrile, the Key Building Block of Ruxolitinib.
Yunfeng Cui, Liangyan Zhu, Xi Chen, Jinhui Feng, Qiaqing Wu, Dunming Zhu

Chembiochem· March 2022

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A New 3-Ketosteroid-Δ-Dehydrogenase with High Activity and Broad Substrate Scope for Efficient Transformation of Hydrocortisone at High Substrate Concentration.
Yu Wang, Rui Zhang, Jinhui Feng, Qiaqing Wu, Dunming Zhu

Microorganisms· February 2022

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[Catalytic mechanism, molecular engineering and applications of threonine aldolases].
Qijia Chen, Xi Chen, Jianxiong Hao, Dunming Zhu

Sheng Wu Gong Cheng Xue Bao· December 2021

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Modulating the active site lid of an alcohol dehydrogenase from Ralstonia sp. enabled efficient stereospecific synthesis of 17β-hydroxysteroids.
Yingying Zhou, Yu Wang, Xi Chen, Jinhui Feng, Min Wang, Dunming Zhu

Enzyme Microb Technol· September 2021

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Asymmetric Synthesis of N-Substituted α-Amino Esters from α-Ketoesters via Imine Reductase-Catalyzed Reductive Amination.
Peiyuan Yao, James R Marshall, Zefei Xu, Jesmine Lim, Simon J Charnock, Dunming Zhu

Angew Chem Int Ed Engl· April 2021

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Crystal Structures and Catalytic Mechanism of l-erythro-3,5-Diaminohexanoate Dehydrogenase and Rational Engineering for Asymmetric Synthesis of β-Amino Acids.
Na Liu, Lian Wu, Jinhui Feng, Xiang Sheng, Jian Li, Dunming Zhu

Angew Chem Int Ed Engl· April 2021

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