Publications by authors named "Eamon Comer"

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Author Correction: Diversity-oriented synthesis yields novel multistage antimalarial inhibitors.
Nobutaka Kato, Eamon Comer, Tomoyo Sakata-Kato, Arvind Sharma, Manmohan Sharma

Nature· December 2025

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Bicyclic Pyrrolidine Inhibitors of Phenylalanine t-RNA Synthetase with Antiparasitic Potency In Vitro and Brain Exposure.
Chloe C Ence, Taher Uddin, Julien Borrel, Payal Mittal, Han Xie, Eamon Comer

ACS Infect Dis· June 2024

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Bicyclic pyrrolidine inhibitors of phenylalanine t-RNA synthetase with antiparasitic potency and brain exposure.
Chloe C Ence, Taher Uddin, Julien Borrel, Payal Mittal, Han Xie, Eamon Comer

bioRxiv· February 2024

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Inhibition of Plasmodium falciparum phenylalanine tRNA synthetase provides opportunity for antimalarial drug development.
Manmohan Sharma, Nachiappan Mutharasappan, Yogavel Manickam, Karl Harlos, Bruno Melillo, Eamon Comer

Structure· July 2022

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Bicyclic azetidines target acute and chronic stages of Toxoplasma gondii by inhibiting parasite phenylalanyl t-RNA synthetase.
Joshua B Radke, Bruno Melillo, Payal Mittal, Manmohan Sharma, Amit Sharma, Eamon Comer

Nat Commun· January 2022

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Structural basis of malaria parasite phenylalanine tRNA-synthetase inhibition by bicyclic azetidines.
Manmohan Sharma, Nipun Malhotra, Manickam Yogavel, Karl Harlos, Bruno Melillo, Eamon Comer

Nat Commun· January 2021

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Bicyclic azetidines kill the diarrheal pathogen in mice by inhibiting parasite phenylalanyl-tRNA synthetase.
Sumiti Vinayak, Rajiv S Jumani, Peter Miller, Muhammad M Hasan, Briana I McLeod, Eamon Comer

Sci Transl Med· September 2020

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Tetracyclines Modify Translation by Targeting Key Human rRNA Substructures.
Jonathan D Mortison, Monica Schenone, Jacob A Myers, Ziyang Zhang, Linfeng Chen, Eamon Comer

Cell Chem Biol· December 2018

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Novel tricyclic glycal-based inducers that reprogram LDL metabolism in hepatic cells.
Marek M Nagiec, Jeremy R Duvall, Adam P Skepner, Eleanor A Howe, Jessica Bastien, Eamon Comer

Medchemcomm· November 2018

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High Throughput Screen Identifies Interferon γ-Dependent Inhibitors of Toxoplasma gondii Growth.
Joshua B Radke, Kimberly L Carey, Subrata Shaw, Shailesh R Metkar, Carol Mulrooney, Eamon Comer

ACS Infect Dis· October 2018

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Synthesis of a Bicyclic Azetidine with In Vivo Antimalarial Activity Enabled by Stereospecific, Directed C(sp)-H Arylation.
Micah Maetani, Jochen Zoller, Bruno Melillo, Oscar Verho, Nobutaka Kato, Eamon Comer

J Am Chem Soc· August 2017

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Diversity-oriented synthesis yields novel multistage antimalarial inhibitors.
Nobutaka Kato, Eamon Comer, Tomoyo Sakata-Kato, Arvind Sharma, Manmohan Sharma

Nature· October 2016

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High-Throughput Luciferase-Based Assay for the Discovery of Therapeutics That Prevent Malaria.
Justine Swann, Victoria Corey, Christina A Scherer, Nobutaka Kato, Eamon Comer

ACS Infect Dis· April 2016

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Modulators of hepatic lipoprotein metabolism identified in a search for small-molecule inducers of tribbles pseudokinase 1 expression.
Marek M Nagiec, Adam P Skepner, Joseph Negri, Michelle Eichhorn, Nicolas Kuperwasser, Eamon Comer

PLoS One· March 2016

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High-Throughput Assay and Discovery of Small Molecules that Interrupt Malaria Transmission.
David M Plouffe, Melanie Wree, Alan Y Du, Stephan Meister, Fengwu Li, Eamon Comer

Cell Host Microbe· January 2016

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Development and Validation of a Novel Leishmania donovani Screening Cascade for High-Throughput Screening Using a Novel Axenic Assay with High Predictivity of Leishmanicidal Intracellular Activity.
Andrea Nühs, Manu De Rycker, Sujatha Manthri, Eamon Comer, Christina A Scherer

PLoS Negl Trop Dis· September 2015

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Utilizing diversity-oriented synthesis in antimicrobial drug discovery.
Eamon Comer, Jeremy R Duvall, Maurice duPont Lee

Future Med Chem· August 2015

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Kinase-Independent Small-Molecule Inhibition of JAK-STAT Signaling.
Danny Hung-Chieh Chou, Amedeo Vetere, Amit Choudhary, Stephen S Scully, Monica Schenone, Eamon Comer

J Am Chem Soc· June 2015

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Diversity-oriented synthesis probe targets Plasmodium falciparum cytochrome b ubiquinone reduction site and synergizes with oxidation site inhibitors.
Amanda K Lukens, Richard W Heidebrecht, Carol Mulrooney, Jennifer A Beaudoin, Eamon Comer

J Infect Dis· April 2015

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Diversity-oriented synthesis-facilitated medicinal chemistry: toward the development of novel antimalarial agents.
Eamon Comer, Jennifer A Beaudoin, Nobutaka Kato, Mark E Fitzgerald, Richard W Heidebrecht

J Med Chem· October 2014

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Lenalidomide causes selective degradation of IKZF1 and IKZF3 in multiple myeloma cells.
Jan Krönke, Namrata D Udeshi, Anupama Narla, Peter Grauman, Slater N Hurst, Eamon Comer

Science· January 2014

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Hits, leads and drugs against malaria through diversity-oriented synthesis.
Sivaraman Dandapani, Eamon Comer, Jeremy R Duvall, Benito Munoz

Future Med Chem· December 2012

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Diversity-Oriented Synthesis Yields a Novel Lead for the Treatment of Malaria.
Richard W Heidebrecht, Carol Mulrooney, Christopher P Austin, Robert H Barker, Jennifer A Beaudoin, Eamon Comer

ACS Med Chem Lett· February 2012

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Diversity-oriented synthesis of 13- to 18-membered macrolactams via ring-closing metathesis.
Sivaraman Dandapani, Jason T Lowe, Eamon Comer, Lisa A Marcaurelle

J Org Chem· October 2011

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Fragment-based domain shuffling approach for the synthesis of pyran-based macrocycles.
Eamon Comer, Haibo Liu, Adrien Joliton, Alexandre Clabaut, Christopher Johnson

Proc Natl Acad Sci U S A· April 2011

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