Publications by authors named "Edgars Jecs"

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Synthesis and Evaluation of Novel Tetrahydronaphthyridine CXCR4 Antagonists with Improved Drug-like Profiles.
Edgars Jecs, Yesim A Tahirovic, Robert J Wilson, Eric J Miller, Michelle Kim

J Med Chem· March 2022

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Amino-Heterocycle Tetrahydroisoquinoline CXCR4 Antagonists with Improved ADME Profiles via Late-Stage Buchwald Couplings.
Huy H Nguyen, Yesim A Tahirovic, Valarie M Truax, Robert J Wilson, Edgars Jecs

ACS Med Chem Lett· October 2021

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Accelerated Discovery of Potent Fusion Inhibitors for Respiratory Syncytial Virus.
Nicole Pribut, Thomas M Kaiser, Robert J Wilson, Edgars Jecs, Zackery W Dentmon

ACS Infect Dis· May 2020

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Small molecule and peptide-based CXCR4 modulators as therapeutic agents. A patent review for the period from 2010 to 2018.
Yesim A Tahirovic, Sameshnee Pelly, Edgars Jecs, Eric J Miller, Savita K Sharma

Expert Opin Ther Pat· February 2020

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Design, Synthesis, and Pharmacological Evaluation of Second-Generation Tetrahydroisoquinoline-Based CXCR4 Antagonists with Favorable ADME Properties.
Huy H Nguyen, Michelle B Kim, Robert J Wilson, Christopher J Butch, Katie M Kuo, Edgars Jecs

J Med Chem· August 2018

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Discovery of -Alkyl Piperazine Side Chain Based CXCR4 Antagonists with Improved Drug-like Properties.
Yesim A Tahirovic, Valarie M Truax, Robert J Wilson, Edgars Jecs, Huy H Nguyen

ACS Med Chem Lett· May 2018

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Discovery of Tetrahydroisoquinoline-Containing CXCR4 Antagonists with Improved in Vitro ADMET Properties.
Eric J Miller, Edgars Jecs, Valarie M Truax, Brooke M Katzman, Yesim A Tahirovic

J Med Chem· February 2018

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Synthesis of Novel Tetrahydroisoquinoline CXCR4 Antagonists with Rigidified Side-Chains.
Edgars Jecs, Eric J Miller, Robert J Wilson, Huy H Nguyen, Yesim A Tahirovic

ACS Med Chem Lett· February 2018

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Synthesis and SAR of 1,2,3,4-Tetrahydroisoquinoline-Based CXCR4 Antagonists.
Robert J Wilson, Edgars Jecs, Eric J Miller, Huy H Nguyen, Yesim A Tahirovic

ACS Med Chem Lett· January 2018

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Two Ene-Yne Metathesis Approaches to the Total Synthesis of Amphidinolide P.
Edgars Jecs, Steven T Diver

Org Lett· July 2015

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Geminal alkene-alkyne cross metathesis using a relay strategy.
Joseph R Clark, Jonathan M French, Edgars Jecs, Steven T Diver

Org Lett· August 2012

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