Publications by authors named "Edmond Fleischer"

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The Molecular Basis of the Intrinsic and Acquired Resistance to Azole Antifungals in .
Parham Hosseini, Mikhail V Keniya, Alia A Sagatova, Stephanie Toepfer, Christoph Müller, Edmond Fleischer

J Fungi (Basel)· November 2024

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Novel artemisinin derivative FO8643 with anti-angiogenic activity inhibits growth and migration of cancer cells via VEGFR2 signaling.
Xiaohua Lu, Sebastian Blatt, Mona Dawood, Sabine M Klauck, Edmond Fleischer

Eur J Pharmacol· September 2022

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Artemisinin derivative FO-ARS-123 as a novel VEGFR2 inhibitor suppresses angiogenesis, cell migration, and invasion.
Xiaohua Lu, Mohamed Elbadawi, Sebastian Blatt, Mohamed E M Saeed, Xiaolin Xiao, Edmond Fleischer

Chem Biol Interact· September 2022

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Transcriptomics, molecular docking, and cross-resistance profiling of nobiletin in cancer cells and synergistic interaction with doxorubicin upon SOX5 transfection.
Aveen N Adham, Sara Abdelfatah, Alaadin Naqishbandi, Yoshikazu Sugimoto, Edmond Fleischer

Phytomedicine· June 2022

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Naphthoquinone derivatives as P-glycoprotein inducers in inflammatory bowel disease: 2D monolayers, 3D spheroids, and in vivo models.
Nuha Mahmoud, Mohamed-Elamir F Hegazy, Walaa Wadie, Mohamed Elbadawi, Edmond Fleischer

Pharmacol Res· May 2022

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Correction to: Identification and characterization of deschloro-chlorothricin obtained from a large natural product library targeting aurora A kinase in multiple myeloma.
Nadire Özenver, Sara Abdelfatah, Anette Klinger, Edmond Fleischer, Thomas Efferth

Invest New Drugs· April 2022

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A novel moniliformin derivative as pan-inhibitor of histone deacetylases triggering apoptosis of leukemia cells.
Xiaohua Lu, Ge Yan, Mona Dawood, Sabine M Klauck, Yoshikazu Sugimoto, Edmond Fleischer

Biochem Pharmacol· December 2021

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Cytotoxicity of 4-hydroxy-N-(naphthalen-1-yl)-2-oxo-2H-chromene-3-carboxamide in multidrug-resistant cancer cells through activation of PERK/eIF2α/ATF4 pathway.
Xiaohua Lu, Ge Yan, Sabine M Klauck, Edmond Fleischer, Anette Klinger

Biochem Pharmacol· November 2021

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Identification of Novel Anthracycline Resistance Genes and Their Inhibitors.
Onat Kadioglu, Mohamed Elbadawi, Edmond Fleischer, Thomas Efferth

Pharmaceuticals (Basel)· October 2021

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A novel ligand of the translationally controlled tumor protein (TCTP) identified by virtual drug screening for cancer differentiation therapy.
Nicolas Fischer, Ean-Jeong Seo, Sara Abdelfatah, Edmond Fleischer, Anette Klinger

Invest New Drugs· August 2021

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Selection of safe artemisinin derivatives using a machine learning-based cardiotoxicity platform and in vitro and in vivo validation.
Onat Kadioglu, Sabine M Klauck, Edmond Fleischer, Letian Shan, Thomas Efferth

Arch Toxicol· July 2021

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Isopetasin and S-isopetasin as novel P-glycoprotein inhibitors against multidrug-resistant cancer cells.
Sara Abdelfatah, Madeleine Böckers, Maitane Asensio, Onat Kadioglu, Anette Klinger, Edmond Fleischer

Phytomedicine· June 2021

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Identification and characterization of deschloro-chlorothricin obtained from a large natural product library targeting aurora A kinase in multiple myeloma.
Nadire Özenver, Sara Abdelfatah, Anette Klinger, Edmond Fleischer, Thomas Efferth

Invest New Drugs· April 2021

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AMG900 as novel inhibitor of the translationally controlled tumor protein.
Nicolas Fischer, Ean-Jeong Seo, Anette Klinger, Edmond Fleischer, Thomas Efferth

Chem Biol Interact· January 2021

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Inhibition of cell migration and induction of apoptosis by a novel class II histone deacetylase inhibitor, MCC2344.
Mona Dawood, Edmond Fleischer, Anette Klinger, Gerhard Bringmann, Letian Shan

Pharmacol Res· October 2020

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Putative molecular determinants mediating sensitivity or resistance towards carnosic acid tumor cell responses.
Nuha Mahmoud, Mohamed E M Saeed, Yoshikazu Sugimoto, Anette Klinger, Edmond Fleischer

Phytomedicine· October 2020

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Vitamin K chloro derivative (VKT-2) inhibits HDAC6, activates autophagy and apoptosis, and inhibits aggresome formation in hepatocellular carcinoma cells.
Mona Dawood, Mohamed-Elamir F Hegazy, Mohamed Elbadawi, Edmond Fleischer, Anette Klinger

Biochem Pharmacol· October 2020

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Chemometric and Transcriptomic Profiling, Microtubule Disruption and Cell Death Induction by Secalonic Acid in Tumor Cells.
Nadire Özenver, Mona Dawood, Edmond Fleischer, Anette Klinger, Thomas Efferth

Molecules· July 2020

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Vitamin K thio-derivative: a novel specific apoptotic inducer in the doxorubicin-sensitive and -resistant cancer cells.
Mohamed-Elamir F Hegazy, Masashi Fukaya, Mona Dawood, Ge Yan, Anette Klinger, Edmond Fleischer

Invest New Drugs· June 2020

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How To Design Selective Ligands for Highly Conserved Binding Sites: A Case Study Using -Myristoyltransferases as a Model System.
Christian Kersten, Edmond Fleischer, Josef Kehrein, Christoph Borek, Elmar Jaenicke

J Med Chem· March 2020

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Identification of inhibitors of the polo-box domain of polo-like kinase 1 from natural and semisynthetic compounds.
Sara Abdelfatah, Edmond Fleischer, Anette Klinger, Vincent Kam Wai Wong, Thomas Efferth

Invest New Drugs· February 2020

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MCC1019, a selective inhibitor of the Polo-box domain of Polo-like kinase 1 as novel, potent anticancer candidate.
Sara Abdelfatah, Angela Berg, Qi Huang, Li Jun Yang, Sami Hamdoun, Edmond Fleischer

Acta Pharm Sin B· September 2019

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Novel 3,4-Dihydroisocoumarins Inhibit Human P-gp and BCRP in Multidrug Resistant Tumors and Demonstrate Substrate Inhibition of Yeast Pdr5.
Julia Sachs, Katja Döhl, Anja Weber, Michele Bonus, Ferdinand Ehlers, Edmond Fleischer

Front Pharmacol· April 2019

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Lawsone derivatives target the Wnt/β-catenin signaling pathway in multidrug-resistant acute lymphoblastic leukemia cells.
Sami Hamdoun, Edmond Fleischer, Anette Klinger, Thomas Efferth

Biochem Pharmacol· December 2017

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Inhibitors of the Candida albicans Major Facilitator Superfamily Transporter Mdr1p Responsible for Fluconazole Resistance.
Mikhail V Keniya, Edmond Fleischer, Anette Klinger, Richard D Cannon, Brian C Monk

PLoS One· April 2016

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