Publications by authors named "Edna C Hardeman"

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Knock-out of Tpm4.2/Actin Filaments Alters Neuronal Signaling, Neurite Outgrowth, and Behavioral Phenotypes in Mice.
Sian Genoud, Chanchanok Chaichim, Rossana Rosa Porto, Tamara Tomanic, Holly Stefen, Edna C Hardeman

Mol Neurobiol· December 2025

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Isoform Specificity of a Compound Targeting Actin Filaments Containing Tropomyosin Tpm1.8/1.9.
Jeff Hook, Edna C Hardeman, Peter W Gunning

Cytoskeleton (Hoboken)· October 2025

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A truncation mutant of adenomatous polyposis coli impairs apical cell extrusion through elevated epithelial tissue tension.
Wan J Gan, Rabina Giri, Jakob Begun, Helen E Abud, Edna C Hardeman

Cytoskeleton (Hoboken)· July 2025

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Single molecule visualization of tropomyosin isoform organization in the mammalian actin cytoskeleton.
Maria L Cagigas, Nicholas Ariotti, Jeff Hook, James Rae, Robert G Parton, Edna C Hardeman

Cytoskeleton (Hoboken)· January 2025

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Coordination of force-generating actin-based modules stabilizes and remodels membranes in vivo.
Marco Heydecker, Akiko Shitara, Desu Chen, Duy T Tran, Andrius Masedunskas, Edna C Hardeman

J Cell Biol· November 2024

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Precision in situ cryogenic correlative light and electron microscopy of optogenetically positioned organelles.
Vikas A Tillu, Gregory M I Redpath, James Rae, Juanfang Ruan, Yin Yao, Edna C Hardeman

J Cell Sci· October 2024

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Tropomyosin1 isoforms underlie epithelial to mesenchymal plasticity, metastatic dissemination, and resistance to chemotherapy in high-grade serous ovarian cancer.
Tong Xu, Mathijs P Verhagen, Miriam Teeuwssen, Wenjie Sun, Rosalie Joosten, Edna C Hardeman

Cell Death Differ· March 2024

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Preexisting tissue mechanical hypertension at adherens junctions disrupts apoptotic extrusion in epithelia.
Zoya Mann, Fayth Lim, Suzie Verma, Bageshri N Nanavati, Julie M Davies, Edna C Hardeman

Mol Biol Cell· January 2024

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Spatial and Temporal Coordination of Force-generating Actin-based Modules Drives Membrane Remodeling .
Marco Heydecker, Akiko Shitara, Desu Chen, Duy Tran, Andrius Masedunskas, Edna C Hardeman

bioRxiv· December 2023

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Different Mouse Models of Nemaline Myopathy Harboring Acta1 Mutations Display Differing Abnormalities Related to Mitochondrial Biology.
Jennifer A Tinklenberg, Rebecca A Slick, Jessica Sutton, Liwen Zhang, Hui Meng, Edna C Hardeman

Am J Pathol· October 2023

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Cortical tension drug screen links mitotic spindle integrity to Rho pathway.
Dejiang Wang, Yao Wang, Xiangjun Di, Fan Wang, Amanda Wanninayaka, Edna C Hardeman

Curr Biol· October 2023

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Highly efficient platelet generation in lung vasculature reproduced by microfluidics.
Xiaojuan Zhao, Dominic Alibhai, Tony G Walsh, Nathalie Tarassova, Maximilian Englert, Edna C Hardeman

Nat Commun· July 2023

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Irradiation-Induced Dysbiosis: The Compounding Effect of High-Fat Diet on Metabolic and Immune Functions in Mice.
Briana K Clifford, Nadia M L Amorim, Nadeem O Kaakoush, Lykke Boysen, Nicodemus Tedla, Edna C Hardeman

Int J Mol Sci· March 2023

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Correlative cryo-ET identifies actin/tropomyosin filaments that mediate cell-substrate adhesion in cancer cells and mechanosensitivity of cell proliferation.
Maria Lastra Cagigas, Nicole S Bryce, Nicholas Ariotti, Simon Brayford, Peter W Gunning, Edna C Hardeman

Nat Mater· January 2022

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Targeting the actin/tropomyosin cytoskeleton in epithelial ovarian cancer reveals multiple mechanisms of synergy with anti-microtubule agents.
Xing Xu, Yao Wang, Nicole S Bryce, Katrina Tang, Nicola S Meagher, Edna C Hardeman

Br J Cancer· July 2021

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A robust method for particulate detection of a genetic tag for 3D electron microscopy.
James Rae, Charles Ferguson, Nicholas Ariotti, Richard I Webb, Han-Hao Cheng, Edna C Hardeman

Elife· April 2021

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Induction of muscle-regenerative multipotent stem cells from human adipocytes by PDGF-AB and 5-azacytidine.
Avani Yeola, Shruthi Subramanian, Rema A Oliver, Christine A Lucas, Julie A I Thoms, Edna C Hardeman

Sci Adv· January 2021

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Visualizing the in vitro assembly of tropomyosin/actin filaments using TIRF microscopy.
Miro Janco, Irina Dedova, Nicole S Bryce, Edna C Hardeman, Peter W Gunning

Biophys Rev· August 2020

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Drug Targeting the Actin Cytoskeleton Potentiates the Cytotoxicity of Low Dose Vincristine by Abrogating Actin-Mediated Repair of Spindle Defects.
Yao Wang, Jeffrey H Stear, Ashleigh Swain, Xing Xu, Nicole S Bryce, Edna C Hardeman

Mol Cancer Res· July 2020

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Impact of the actin cytoskeleton on cell development and function mediated via tropomyosin isoforms.
Edna C Hardeman, Nicole S Bryce, Peter W Gunning

Semin Cell Dev Biol· June 2020

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Tropomyosin Tpm3.1 Is Required to Maintain the Structure and Function of the Axon Initial Segment.
Amr Abouelezz, Holly Stefen, Mikael Segerstråle, David Micinski, Rimante Minkeviciene, Edna C Hardeman

iScience· May 2020

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Irradiation impairs mitochondrial function and skeletal muscle oxidative capacity: significance for metabolic complications in cancer survivors.
Nadia M L Amorim, Anthony Kee, Adelle C F Coster, Christine Lucas, Sarah Bould, Edna C Hardeman

Metabolism· February 2020

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Life and death agendas of actin filaments.
Edna C Hardeman, Peter W Gunning

Nat Mater· February 2020

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High-Content Imaging of Unbiased Chemical Perturbations Reveals that the Phenotypic Plasticity of the Actin Cytoskeleton Is Constrained.
Nicole S Bryce, Tim W Failes, Justine R Stehn, Karen Baker, Stefan Zahler, Edna C Hardeman

Cell Syst· November 2019

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Molecular integration of the anti-tropomyosin compound ATM-3507 into the coiled coil overlap region of the cancer-associated Tpm3.1.
Miro Janco, Michael J Rynkiewicz, Liang Li, Jeff Hook, Eleanor Eiffe, Edna C Hardeman

Sci Rep· August 2019

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