Publications by authors named "Edward Bertaccini"

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Assessment of a new class of slow γ-aminobutyric acid type A receptor anesthetic on mouse neuronal and astrocyte mitochondrial function.
Creed M Stary, Brian Griffiths, Xiaoyun Sun, Frances Davies, Alam Jahangir, Edward Bertaccini

Res Sq· September 2025

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Comparative Electroencephalographic Profile of a New Anesthetic and Anticonvulsant That Is Selective for the GABA A R Slow Receptor Subtype.
M Bruce Maciver, Hillary S McCarren, Sarah L Eagleman, Frances M Davies, Alam Jahangir, Edward J Bertaccini

Anesth Analg· August 2025

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Anesthesia, Coming of Age in the World of Modern In Silico Drug Design.
Edward J Bertaccini

Anesthesiology· February 2023

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Modulation of α1β3γ2 GABA receptors expressed in oocytes using a propofol photoswitch tethered to the transmembrane helix.
Cecilia M Borghese, Hua-Yu L Wang, Stanton F McHardy, Robert O Messing, James R Trudell, Edward J Bertaccini

Proc Natl Acad Sci U S A· February 2021

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An In Vitro Model for Identifying Cardiac Side Effects of Anesthetics.
Alex C Y Chang, Andrew C H Chang, Luka Nicin, Gerhard J Weber, Colin Holbrook, Edward J Bertaccini

Anesth Analg· January 2020

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A newly developed anesthetic based on a unique chemical core.
Noëlie S Cayla, Beza A Dagne, Yun Wu, Yao Lu, Larry Rodriguez, Edward J Bertaccini

Proc Natl Acad Sci U S A· July 2019

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Insights Into Receptor-Based Anesthetic Pharmacophores and Anesthetic-Protein Interactions.
Victoria S Fahrenbach, Edward J Bertaccini

Methods Enzymol· April 2019

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The Role of the Hydroxyl Group in Propofol-Protein Target Recognition: Insights from ONIOM Studies.
Ling Qiu, Jianguo Lin, Qingzhu Liu, Shanshan Wang, Gaochao Lv, Edward J Bertaccini

J Phys Chem B· June 2017

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Design and Implementation of a Perioperative Surgical Home at a Veterans Affairs Hospital.
Tessa L Walters, Steven K Howard, Alex Kou, Edward J Bertaccini, T Kyle Harrison

Semin Cardiothorac Vasc Anesth· June 2016

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Identification of an Inhibitory Alcohol Binding Site in GABAA ρ1 Receptors.
Cecilia M Borghese, Carlos I Ruiz, Ui S Lee, Madeline A Cullins, Edward J Bertaccini

ACS Chem Neurosci· January 2016

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Insights into the Nature of Anesthetic-Protein Interactions: An ONIOM Study.
Ling Qiu, Jianguo Lin, Edward J Bertaccini

J Phys Chem B· October 2015

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Invasive Mechanical Ventilation in California Over 2000-2009: Implications for Emergency Medicine.
Seshadri C Mudumbai, Juli Barr, Jennifer Scott, Edward R Mariano, Edward Bertaccini

West J Emerg Med· September 2015

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Molecular modeling of a tandem two pore domain potassium channel reveals a putative binding site for general anesthetics.
Edward J Bertaccini, Robert Dickinson, James R Trudell, Nicholas P Franks

ACS Chem Neurosci· December 2014

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Structural models of ligand-gated ion channels: sites of action for anesthetics and ethanol.
Richard W Olsen, Guo-Dong Li, Martin Wallner, James R Trudell, Edward J Bertaccini

Alcohol Clin Exp Res· March 2014

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Assessment of homology templates and an anesthetic binding site within the γ-aminobutyric acid receptor.
Edward J Bertaccini, Ozge Yoluk, Erik R Lindahl, James R Trudell

Anesthesiology· November 2013

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Stabilization of the GluCl ligand-gated ion channel in the presence and absence of ivermectin.
Ozge Yoluk, Torben Brömstrup, Edward J Bertaccini, James R Trudell, Erik Lindahl

Biophys J· August 2013

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Molecular mechanism for the dual alcohol modulation of Cys-loop receptors.
Samuel Murail, Rebecca J Howard, Torben Broemstrup, Edward J Bertaccini, R Adron Harris

PLoS Comput Biol· May 2013

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Teaching an old GABA receptor new tricks.
James R Trudell, Edward Bertaccini, M Bruce Maciver

Anesth Analg· August 2012

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Induced changes in protein receptors conferring resistance to anesthetics.
Edward J Bertaccini, James R Trudell

Curr Opin Anaesthesiol· August 2012

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Association of admission hematocrit with 6-month and 1-year mortality in intensive care unit patients.
Seshadri C Mudumbai, Ruth Cronkite, Kirsten U Hu, Todd Wagner, Ko Hayashi, Edward Bertaccini

Transfusion· October 2011

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Microsecond simulations indicate that ethanol binds between subunits and could stabilize an open-state model of a glycine receptor.
Samuel Murail, Björn Wallner, James R Trudell, Edward Bertaccini, Erik Lindahl

Biophys J· April 2011

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Modeling anesthetic binding sites within the glycine alpha one receptor based on prokaryotic ion channel templates: the problem with TM4.
Edward J Bertaccini, Björn Wallner, James R Trudell, Erik Lindahl

J Chem Inf Model· December 2010

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Normal mode gating motions of a ligand-gated ion channel persist in a fully hydrated lipid bilayer model.
Edward J Bertaccini, James R Trudell, Erik Lindahl

ACS Chem Neurosci· August 2010

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The Molecular Mechanisms of Anesthetic Action: Updates and Cutting Edge Developments from the Field of Molecular Modeling.
Edward J Bertaccini

Pharmaceuticals (Basel)· July 2010

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Disruption of an intersubunit electrostatic bond is a critical step in glycine receptor activation.
Jelena Todorovic, Brian T Welsh, Edward J Bertaccini, James R Trudell, S John Mihic

Proc Natl Acad Sci U S A· April 2010

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