Publications by authors named "Edward D Sturrock"

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Ciprofloxacin Inhibits Angiotensin I‑Converting Enzyme (ACE) Activity by Binding at the Exosite, Distal to the Catalytic Pocket.
Kyle S Gregory, Vinasha Ramasamy, Edward D Sturrock, K Ravi Acharya

ACS Bio Med Chem Au· October 2025

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Molecular basis of domain-specific angiotensin I-converting enzyme inhibition by the antihypertensive drugs enalaprilat, ramiprilat, trandolaprilat, quinaprilat and perindoprilat.
Kyle S Gregory, Vinasha Ramasamy, Edward D Sturrock, K Ravi Acharya

FEBS J· August 2025

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Design of Novel Mercapto-3-phenylpropanoyl Dipeptides as Dual Angiotensin-Converting Enzyme C-Domain-Selective/Neprilysin Inhibitors.
Gyles E Cozier, Lauren B Coulson, Charles J Eyermann, Gregory S Basarab, Sylva L Schwager, Edward D Sturrock

J Med Chem· April 2025

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Molecular basis of human angiotensin-1 converting enzyme inhibition by a series of diprolyl-derived compounds.
Kyle S Gregory, Gyles E Cozier, Stephen Fienberg, Kelly Chibale, Edward D Sturrock

FEBS J· March 2025

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Advances in the structural basis for angiotensin-1 converting enzyme (ACE) inhibitors.
K Ravi Acharya, Kyle S Gregory, Edward D Sturrock

Biosci Rep· August 2024

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Proteomic Analysis of Human Macrophages Overexpressing Angiotensin-Converting Enzyme.
Delia Oosthuizen, Tariq A Ganief, Kenneth E Bernstein, Edward D Sturrock

Int J Mol Sci· June 2024

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Structural insights into the inhibitory mechanism of angiotensin-I-converting enzyme by the lactotripeptides IPP and VPP.
Kyle S Gregory, Gyles E Cozier, Sylva L U Schwager, Edward D Sturrock, K Ravi Acharya

FEBS Lett· January 2024

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Peptide inhibitors of angiotensin-I converting enzyme based on angiotensin (1-7) with selectivity for the C-terminal domain.
Rogerio L da Silva, Athanasios Papakyriakou, Adriana K Carmona, Georgios A Spyroulias, Edward D Sturrock

Bioorg Chem· December 2022

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Structural basis for the inhibition of human angiotensin-1 converting enzyme by fosinoprilat.
Gyles E Cozier, Emma C Newby, Sylva L U Schwager, R Elwyn Isaac, Edward D Sturrock

FEBS J· November 2022

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The Angiotensin AT Receptor: From a Binding Site to a Novel Therapeutic Target.
U Muscha Steckelings, Robert E Widdop, Edward D Sturrock, Lizelle Lubbe, Tahir Hussain

Pharmacol Rev· October 2022

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Cryo-EM reveals mechanisms of angiotensin I-converting enzyme allostery and dimerization.
Lizelle Lubbe, Bryan Trevor Sewell, Jeremy D Woodward, Edward D Sturrock

EMBO J· August 2022

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Exploring the Impact of ACE Inhibition in Immunity and Disease.
Delia Oosthuizen, Edward D Sturrock

J Renin Angiotensin Aldosterone Syst· August 2022

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Probing the Requirements for Dual Angiotensin-Converting Enzyme C-Domain Selective/Neprilysin Inhibition.
Lauren B Arendse, Gyles E Cozier, Charles J Eyermann, Gregory S Basarab, Sylva L Schwager, Edward D Sturrock

J Med Chem· February 2022

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Epitope mapping of novel monoclonal antibodies to human angiotensin I-converting enzyme.
Isolda A Popova, Lizelle Lubbe, Pavel A Petukhov, Gavriil F Kalantarov, Ilya N Trakht, Edward D Sturrock

Protein Sci· August 2021

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Novel ACE mutations mimicking sarcoidosis by increasing blood ACE levels.
Sergei M Danilov, Mark S Jain, Pavel A Petukhov, Chananya Goldman, Maria DiSanto-Rose, Edward D Sturrock

Transl Res· April 2021

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Angiotensin-converting enzyme open for business: structural insights into the subdomain dynamics.
Gyles E Cozier, Lizelle Lubbe, Edward D Sturrock, K Ravi Acharya

FEBS J· April 2021

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Prospects for SARS-CoV-2 diagnostics, therapeutics and vaccines in Africa.
Emmanuel Margolin, Wendy A Burgers, Edward D Sturrock, Marc Mendelson, Rosamund Chapman

Nat Rev Microbiol· December 2020

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ACE2 and ACE: structure-based insights into mechanism, regulation and receptor recognition by SARS-CoV.
Lizelle Lubbe, Gyles E Cozier, Delia Oosthuizen, K Ravi Acharya, Edward D Sturrock

Clin Sci (Lond)· November 2020

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Molecular Basis for Omapatrilat and Sampatrilat Binding to Neprilysin-Implications for Dual Inhibitor Design with Angiotensin-Converting Enzyme.
Urvashi Sharma, Gyles E Cozier, Edward D Sturrock, K Ravi Acharya

J Med Chem· May 2020

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ACE-domain selectivity extends beyond direct interacting residues at the active site.
Gyles E Cozier, Lizelle Lubbe, Edward D Sturrock, K Ravi Acharya

Biochem J· April 2020

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Novel Therapeutic Approaches Targeting the Renin-Angiotensin System and Associated Peptides in Hypertension and Heart Failure.
Lauren B Arendse, A H Jan Danser, Marko Poglitsch, Rhian M Touyz, John C Burnett, Edward D Sturrock

Pharmacol Rev· October 2019

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Interacting cogs in the machinery of the renin angiotensin system.
Lizelle Lubbe, Edward D Sturrock

Biophys Rev· June 2019

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Structural basis for the C-domain-selective angiotensin-converting enzyme inhibition by bradykinin-potentiating peptide b (BPPb).
Edward D Sturrock, Lizelle Lubbe, Gyles E Cozier, Sylva L U Schwager, Afolake T Arowolo

Biochem J· May 2019

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Molecular Basis for Multiple Omapatrilat Binding Sites within the ACE C-Domain: Implications for Drug Design.
Gyles E Cozier, Lauren B Arendse, Sylva L Schwager, Edward D Sturrock, K Ravi Acharya

J Med Chem· November 2018

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Established and novel pathophysiological mechanisms of pericardial injury and constrictive pericarditis.
Vinasha Ramasamy, Bongani M Mayosi, Edward D Sturrock, Mpiko Ntsekhe

World J Cardiol· September 2018

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