Publications by authors named "Edward Hanley"

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Interleukin-23 is constitutively expressed in the human annulus in vivo and in vitro, and is up-regulated in vitro by TNF-α.
H E Gruber, E Marrero, M Cox, Edward Hanley

Biotech Histochem· October 2019

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The role of inhibition by phosphocitrate and its analogue in chondrocyte differentiation and subchondral bone advance in Hartley guinea pigs.
Yubo Sun, Alex J Kiraly, Michael Cox, David R Mauerhan, Edward N Hanley

Exp Ther Med· April 2018

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Cell Clusters Are Indicative of Stem Cell Activity in the Degenerate Intervertebral Disc: Can Their Properties Be Manipulated to Improve Intrinsic Repair of the Disc?
Sharon Brown, Ajay Matta, Mark Erwin, Sally Roberts, Helen E Gruber, Edward N Hanley

Stem Cells Dev· February 2018

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Biological effects and osteoarthritic disease-modifying activity of small molecule CM-01.
Yubo Sun, Andrea Roberts, David R Mauerhan, Michael Cox, Edward N Hanley

J Orthop Res· January 2018

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Proinflammatory Cytokines IL-1β and TNF-α Influence Human Annulus Cell Signaling Cues for Neurite Growth: In Vitro Coculture Studies.
Helen E Gruber, Brittany Jones, Emilio Marrero, Edward N Hanley

Spine (Phila Pa 1976)· October 2017

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Mucin 1, a signal transduction membrane-bound mucin, is present in human disc tissue and is downregulated in vitro by exposure to IL-1ß or TNF-α.
Helen E Gruber, Jane A Ingram, Gretchen L Hoelscher, Emilio Marrero, Edward N Hanley

BMC Musculoskelet Disord· May 2017

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Biological Effects of Phosphocitrate on Osteoarthritic Articular Chondrocytes.
Yubo Sun, Atiya M Franklin, David R Mauerhan, Edward N Hanley

Open Rheumatol J· May 2017

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Comparison of Meniscal Cell-Mediated and Chondrocyte-Mediated Calcification.
Alex J Kiraly, Andrea Roberts, Michael Cox, David Mauerhan, Edward Hanley

Open Orthop J· March 2017

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Human annulus signaling cues for nerve outgrowth: In vitro studies.
Helen E Gruber, Gretchen L Hoelscher, Letitia Bullock, Jane A Ingram, H James Norton, Edward N Hanley

J Orthop Res· August 2016

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Human annulus progenitor cells: Analyses of this viable endogenous cell population.
Helen E Gruber, Frank E Riley, Gretchen L Hoelscher, Jane A Ingram, Letitia Bullock, Edward N Hanley

J Orthop Res· August 2016

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Cartilage Degeneration, Subchondral Mineral and Meniscal Mineral Densities in Hartley and Strain 13 Guinea Pigs.
Yubo Sun, Brian P Scannell, Patrick R Honeycutt, David R Mauerhan, James Norton H, Edward N Hanley

Open Rheumatol J· September 2015

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Disease-modifying effects of phosphocitrate and phosphocitrate-β-ethyl ester on partial meniscectomy-induced osteoarthritis.
Yubo Sun, Nikkole Haines, Andrea Roberts, Michael Ruffolo, David R Mauerhan, Edward N Hanley

BMC Musculoskelet Disord· September 2015

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Expression of phosphocitrate-targeted genes in osteoarthritis menisci.
Yubo Sun, David R Mauerhan, Nury M Steuerwald, Jane Ingram, Jeffrey S Kneisl, Edward N Hanley

Biomed Res Int· August 2015

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High-mobility group box-1 gene, a potent proinflammatory mediators, is upregulated in more degenerated human discs in vivo and its receptor upregulated by TNF-α exposure in vitro.
Helen E Gruber, Gretchen L Hoelscher, Synthia Bethea, Jane Ingram, Michael Cox, Edward N Hanley

Exp Mol Pathol· June 2015

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Mitochondrial Membrane Potential and Nuclear and Gene Expression Changes During Human Disc Cell Apoptosis: In Vitro and In Vivo Annulus Findings.
Helen E Gruber, Gretchen L Hoelscher, Synthia Bethea, Edward N Hanley

Spine (Phila Pa 1976)· June 2015

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Autophagy in the Degenerating Human Intervertebral Disc: In Vivo Molecular and Morphological Evidence, and Induction of Autophagy in Cultured Annulus Cells Exposed to Proinflammatory Cytokines-Implications for Disc Degeneration.
Helen E Gruber, Gretchen L Hoelscher, Jane A Ingram, Synthia Bethea, Edward N Hanley

Spine (Phila Pa 1976)· June 2015

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Proinflammatory cytokines modulate the chemokine CCL2 (MCP-1) in human annulus cells in vitro: CCL2 expression and production.
Helen E Gruber, Gretchen L Hoelscher, Jane A Ingram, Synthia Bethea, Michael Cox, Edward N Hanley

Exp Mol Pathol· February 2015

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Alkaptonuria-Associated Changes in Disc Degeneration: A Case Report.
Helen E Gruber, Edward N Hanley

JBJS Case Connect· January 2015

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A novel catechol-O-methyltransferase variant associated with human disc degeneration.
Helen E Gruber, Wei Sha, Cory R Brouwer, Nury Steuerwald, Gretchen L Hoelscher, Edward N Hanley

Int J Med Sci· December 2014

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Cortistatin is endogenous to the human intervertebral disc and exerts in vitro mitogenic effects on annulus cells and a downregulatory effect on TNF-α expression.
Helen E Gruber, Gretchen L Hoelscher, Synthia F Bethea, Evan A Menscher, Jane A Ingram, Edward N Hanley

Spine J· December 2014

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Matrix metalloproteinase-12 immunolocalization in the degenerating human intervertebral disc and sand rat spine: Biologic implications.
Helen E Gruber, Jane A Ingram, Michael D Cox, Edward N Hanley

Exp Mol Pathol· August 2014

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Spontaneous age-related cervical disc degeneration in the sand rat.
Helen E Gruber, Ryan Phillips, Jane A Ingram, H James Norton, Edward N Hanley

Clin Orthop Relat Res· June 2014

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Fibroblast-like synoviocytes induce calcium mineral formation and deposition.
Yubo Sun, David R Mauerhan, Atiya M Franklin, Natalia Zinchenko, Harry James Norton, Edward N Hanley

Arthritis· June 2014

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Production and expression of RANTES (CCL5) by human disc cells and modulation by IL-1-β and TNF-α in 3D culture.
Helen E Gruber, Gretchen L Hoelscher, Jane A Ingram, Synthia Bethea, H James Norton, Edward N Hanley

Exp Mol Pathol· April 2014

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Growth and differentiation factor-5 (GDF-5) in the human intervertebral annulus cells and its modulation by IL-1ß and TNF-α in vitro.
Helen E Gruber, Gretchen L Hoelscher, Jane A Ingram, Synthia Bethea, Edward N Hanley

Exp Mol Pathol· April 2014

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