Publications by authors named "Edward Lock"

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Increased prevalence of Parkinson's disease in alkaptonuria.
Lakshminarayan Ranganath, Milad Khedr, Anna M Milan, Andrew S Davison, Brendan P Norman, Edward Lock

JIMD Rep· July 2023

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The Discovery of the Mode of Action of Nitisinone.
Edward A Lock

Metabolites· September 2022

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Inhibition of rat brain and human red cell acetylcholinesterase by thiocarbamate herbicides.
Edward A Lock

Toxicol Res (Camb)· September 2020

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The effect of trichloroethylene metabolites on the hepatic vitamin B-dependent methionine salvage pathway and its relevance to increased excretion of formic acid in the rat.
Noreen Yaqoob, Katarzyna M Bloch, Andrew R Evans, Edward A Lock

Toxicol Res (Camb)· April 2020

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From Weed Killer to Wonder Drug.
Edward A Lock

Adv Exp Med Biol· December 2017

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Trichloroethylene-induced formic aciduria in the male C Bl/6 mouse.
Edward A Lock, Paul Keane, Philip H Rowe, John R Foster, Daniel Antoine

Toxicology· March 2017

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Aristolochic acids - Induced transcriptomic responses in rat renal proximal tubule cells in vitro.
Katarzyna M Bloch, Andrew Evans, Edward A Lock

Genom Data· September 2015

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The role of nitisinone in tyrosine pathway disorders.
Edward Lock, Lakshminarayan R Ranganath, Oliver Timmis

Curr Rheumatol Rep· November 2014

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Trichloroethylene and trichloroethanol-induced formic aciduria and renal injury in male F-344 rats following 12 weeks exposure.
Noreen Yaqoob, Andrew Evans, John R Foster, Edward A Lock

Toxicology· September 2014

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Trichloroethylene-induced formic aciduria: effect of dose, sex and strain of rat.
Noreen Yaqoob, Andrew R Evans, Edward A Lock

Toxicology· February 2013

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Solvents and Parkinson disease: a systematic review of toxicological and epidemiological evidence.
Edward A Lock, Jing Zhang, Harvey Checkoway

Toxicol Appl Pharmacol· February 2013

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Oxidative stress induced by potassium bromate exposure results in altered tight junction protein expression in renal proximal tubule cells.
Alice Limonciel, Anja Wilmes, Lydia Aschauer, Robert Radford, Katarzyna M Bloch, Edward A Lock

Arch Toxicol· November 2012

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Transcriptomic alterations induced by Ochratoxin A in rat and human renal proximal tubular in vitro models and comparison to a rat in vivo model.
Paul Jennings, Christina Weiland, Alice Limonciel, Katarzyna M Bloch, Robert Radford, Edward A Lock

Arch Toxicol· April 2012

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Biological qualification of biomarkers of chemical-induced renal toxicity in two strains of male rat.
Ernie Harpur, Daniela Ennulat, David Hoffman, Graham Betton, Jean-Charles Gautier, Edward Lock

Toxicol Sci· August 2011

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Sensitive and early markers of renal injury: where are we and what is the way forward?
Edward A Lock

Toxicol Sci· July 2010

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The carcinoGENOMICS project: critical selection of model compounds for the development of omics-based in vitro carcinogenicity screening assays.
Mathieu Vinken, Tatyana Doktorova, Heidrun Ellinger-Ziegelbauer, Hans-Jürgen Ahr, Edward Lock

Mutat Res· October 2008

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Biomarkers in translation; past, present and future.
Edward A Lock, Joseph V Bonventre

Toxicology· March 2008

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Proteomics of S-(1, 2-dichlorovinyl)-L-cysteine-induced acute renal failure and autoprotection in mice.
Midhun C Korrapati, Jaya Chilakapati, Frank A Witzmann, Chundury Rao, Edward A Lock

Am J Physiol Renal Physiol· October 2007

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Lack of formic acid production in rat hepatocytes and human renal proximal tubule cells exposed to chloral hydrate or trichloroacetic acid.
Edward A Lock, Celia J Reed, Joellyn M McMillan, John E Oatis, Rick G Schnellmann

Toxicology· February 2007

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Caspase-dependent and -independent induction of phosphatidylserine externalization during apoptosis in human renal carcinoma Cak(1)-1 and A-498 cells.
Edward A Lock, Celia J Reed, Gilbert R Kinsey, Rick G Schnellmann

Toxicology· January 2007

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Changes in gene expression in human renal proximal tubule cells exposed to low concentrations of S-(1,2-dichlorovinyl)-l-cysteine, a metabolite of trichloroethylene.
Edward A Lock, Jeremy L Barth, Scott W Argraves, Rick G Schnellmann

Toxicol Appl Pharmacol· October 2006

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Calpastatin overexpression prevents progression of S-1,2-dichlorovinyl-l-cysteine (DCVC)-initiated acute renal injury and renal failure (ARF) in diabetes.
Ankur V Dnyanmote, Sharmilee P Sawant, Edward A Lock, John R Latendresse, Alan A Warbritton

Toxicol Appl Pharmacol· September 2006

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Preplaced cell division: a critical mechanism of autoprotection against S-1,2-dichlorovinyl-L-cysteine-induced acute renal failure and death in mice.
Midhun C Korrapati, Jaya Chilakapati, Edward A Lock, John R Latendresse, Alan Warbritton

Am J Physiol Renal Physiol· August 2006

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Tyrosinemia produced by 2-(2-nitro-4-trifluoromethylbenzoyl)-cyclohexane-1,3-dione (NTBC) in experimental animals and its relationship to corneal injury.
Edward A Lock, Peter Gaskin, Martin Ellis, William M Provan, Lewis L Smith

Toxicol Appl Pharmacol· August 2006

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Trichloroethylene: mechanisms of renal toxicity and renal cancer and relevance to risk assessment.
Edward A Lock, Celia J Reed

Toxicol Sci· June 2006

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