Publications by authors named "Edward P Debold"

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The order of things: phosphate release or the power stroke, which does actomyosin do first?
Edward P Debold, Christopher P Marang, Brent D Scott

Front Physiol· December 2025

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A human skeletal muscle cross-bridge model to characterize the role of metabolite accumulation in muscle fatigue.
John I Hendry, Muhammet Enes Erol, Gwenael Layec, Edward P Debold, Shivendra G Tewari

Exp Physiol· September 2025

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Characterizing the concentration and load dependence of phosphate binding to rabbit fast skeletal actomyosin.
Christopher P Marang, Daniel J Petersen, Brent D Scott, Sam Walcott, Edward P Debold

Proc Natl Acad Sci U S A· May 2025

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Cellular and molecular contractile function in aged human skeletal muscle is altered by phosphate and acidosis and partially reversed with an ATP analog.
Aurora D Foster, Chad R Straight, Philip C Woods, Christopher Lee, Jane A Kent, Edward P Debold

Am J Physiol Cell Physiol· April 2025

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New insights into the cellular and molecular mechanisms of skeletal muscle fatigue: the Marion J. Siegman Award Lectureships.
Edward P Debold, Håkan Westerblad

Am J Physiol Cell Physiol· October 2024

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In defense of Huxley.
Sam Walcott, Sean Sun, Edward P Debold, Walter Herzog

Biophys J· October 2024

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A mutation in switch I alters the load-dependent kinetics of myosin Va.
Christopher Marang, Brent Scott, James Chambers, Laura K Gunther, Christopher M Yengo, Edward P Debold

Nat Commun· May 2023

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Recent insights into the relative timing of myosin's powerstroke and release of phosphate.
Edward P Debold

Cytoskeleton (Hoboken)· September 2021

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Myosin's powerstroke occurs prior to the release of phosphate from the active site.
Brent Scott, Christopher Marang, Mike Woodward, Edward P Debold

Cytoskeleton (Hoboken)· May 2021

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FRET and optical trapping reveal mechanisms of actin activation of the power stroke and phosphate release in myosin V.
Laura K Gunther, John A Rohde, Wanjian Tang, Joseph A Cirilo, Christopher P Marang, Edward P Debold

J Biol Chem· December 2020

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Positional Isomers of a Non-Nucleoside Substrate Differentially Affect Myosin Function.
Mike Woodward, Eric Ostrander, Seung P Jeong, Xiarong Liu, Brent Scott, Edward P Debold

Biophys J· August 2020

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Acidosis decreases the Ca sensitivity of thin filaments by preventing the first actomyosin interaction.
Matthew Unger, Edward P Debold

Am J Physiol Cell Physiol· October 2019

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Acidosis affects muscle contraction by slowing the rates myosin attaches to and detaches from actin.
Katelyn Jarvis, Mike Woodward, Edward P Debold, Sam Walcott

J Muscle Res Cell Motil· August 2018

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Acidosis and Phosphate Directly Reduce Myosin's Force-Generating Capacity Through Distinct Molecular Mechanisms.
Mike Woodward, Edward P Debold

Front Physiol· July 2018

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The molecular basis of thin filament activation: from single molecule to muscle.
Thomas Longyear, Sam Walcott, Edward P Debold

Sci Rep· May 2017

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Muscle Fatigue from the Perspective of a Single Crossbridge.
Edward P Debold, Robert H Fitts, Christopher W Sundberg, Thomas M Nosek

Med Sci Sports Exerc· November 2016

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Decreased Myofilament Calcium Sensitivity Plays a Significant Role in Muscle Fatigue.
Edward P Debold

Exerc Sport Sci Rev· October 2016

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Potential molecular mechanisms underlying muscle fatigue mediated by reactive oxygen and nitrogen species.
Edward P Debold

Front Physiol· September 2015

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Modifications of myofilament protein phosphorylation and function in response to cardiac arrest induced in a swine model.
Mike Woodward, Michael J Previs, Timothy J Mader, Edward P Debold

Front Physiol· August 2015

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Biological machines: Molecular motor teamwork.
Edward P Debold

Nat Nanotechnol· August 2015

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Phosphate and acidosis act synergistically to depress peak power in rat muscle fibers.
Cassandra R Nelson, Edward P Debold, Robert H Fitts

Am J Physiol Cell Physiol· November 2014

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Magnesium modulates actin binding and ADP release in myosin motors.
Anja M Swenson, Darshan V Trivedi, Anna A Rauscher, Yuan Wang, Yasuharu Takagi, Edward P Debold

J Biol Chem· August 2014

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Ca++-sensitizing mutations in troponin, P(i), and 2-deoxyATP alter the depressive effect of acidosis on regulated thin-filament velocity.
Thomas J Longyear, Matthew A Turner, Jonathan P Davis, Joseph Lopez, Brandon Biesiadecki, Edward P Debold

J Appl Physiol (1985)· May 2014

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Direct observation of phosphate inhibiting the force-generating capacity of a miniensemble of Myosin molecules.
Edward P Debold, Sam Walcott, Mike Woodward, Matthew A Turner

Biophys J· November 2013

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Cardiac muscle activation blunted by a mutation to the regulatory component, troponin T.
Minae Kobayashi, Edward P Debold, Matthew A Turner, Tomoyoshi Kobayashi

J Biol Chem· September 2013

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