Publications by authors named "Edward Timofeev"

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Thymidine-Inosine Dimer Building Block for Reversible Modification of Synthetic Oligonucleotides.
Natalia A Kolganova, Irina V Varizhuk, Andrey A Stomakhin, Marat M Khisamov, Pavel N Solyev, Edward N Timofeev

Molecules· September 2025

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Alpha-2'-deoxyguanosine promotes highly stable anti-parallel G-quadruplex DNA structures with therapeutic potential via guided G-quadruplex assembly.
Irina V Varizhuk, Andrey A Stomakhin, Anna N Ermolaeva, Ksenia V Petrova, Sergei A Surzhikov, Edward N Timofeev

Int J Biol Macromol· August 2025

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Alpha-Deoxyguanosine to Reshape the Alpha-Thrombin Binding Aptamer.
Natalia A Kolganova, Vladimir B Tsvetkov, Andrey A Stomakhin, Sergei A Surzhikov, Edward N Timofeev

Int J Mol Sci· May 2023

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The Regioselective Conjugation of the 15-nt Thrombin Aptamer with an Optimized Tripeptide Sequence Greatly Increases the Anticoagulant Activity of the Aptamer.
Irina V Varizhuk, Vladimir B Tsvetkov, Ilya Yu Toropygin, Andrey A Stomakhin, Natalia A Kolganova, Edward N Timofeev

Pharmaceutics· February 2023

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Anticoagulant Oligonucleotide-Peptide Conjugates: Identification of Thrombin Aptamer Conjugates with Improved Characteristics.
Vladimir B Tsvetkov, Irina V Varizhuk, Nikolay N Kurochkin, Sergei A Surzhikov, Igor P Smirnov, Edward N Timofeev

Int J Mol Sci· March 2022

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Recognition Interface of the Thrombin Binding Aptamer Requires Antiparallel Topology of the Quadruplex Core.
Julia Svetlova, Makar Sardushkin, Natalia Kolganova, Edward Timofeev

Biomolecules· September 2021

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Expanding the recognition interface of the thrombin-binding aptamer HD1 through modification of residues T3 and T12.
Igor Smirnov, Natalia Kolganova, Romualdo Troisi, Filomena Sica, Edward Timofeev

Mol Ther Nucleic Acids· March 2021

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Mononucleotide repeat expansions with non-natural polymerase substrates.
Alexander V Chudinov, Vadim A Vasiliskov, Viktoriya E Kuznetsova, Sergey A Lapa, Natalia A Kolganova, Edward N Timofeev

Sci Rep· January 2021

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Folding topology, structural polymorphism, and dimerization of intramolecular DNA G-quadruplexes with inverted polarity strands and non-natural loops.
Igor P Smirnov, Natalia A Kolganova, Sergei A Surzhikov, Irina V Grechishnikova, Roman A Novikov, Edward N Timofeev

Int J Biol Macromol· November 2020

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Probing the Nitroindole-Modified Central Loop of Thrombin Aptamer HD1 as a Recognition Site.
Natalia A Kolganova, Vladimir B Tsvetkov, Igor P Smirnov, Edward N Timofeev

Nucleic Acid Ther· August 2019

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Factors Affecting the Tailing of Blunt End DNA with Fluorescent Pyrimidine dNTPs.
Natalia A Kolganova, Vadim A Vasiliskov, Viktoriya E Kuznetsova, Valeriy E Shershov, Sergey A Lapa, Edward N Timofeev

Mol Biotechnol· December 2018

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Mass-spectrometry analysis of modifications at DNA termini induced by DNA polymerases.
Igor P Smirnov, Natalia A Kolganova, Vadim A Vasiliskov, Alexander V Chudinov, Edward N Timofeev

Sci Rep· July 2017

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Hydrogel microarray for detection of polymorphisms in the UGT1A1, DPYD, GSTP1 and ABCB1 genes.
Rustam Heydarov, Sergei Titov, Mikhail Abramov, Edward Timofeev, Vladimir Mikhailovich

Cancer Biomark· April 2017

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The Toolbox for Modified Aptamers.
Sergey A Lapa, Alexander V Chudinov, Edward N Timofeev

Mol Biotechnol· February 2016

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Anomeric DNA quadruplexes.
Natalia A Kolganova, Anna M Varizhuk, Roman A Novikov, Vladimir L Florentiev, Galina E Pozmogova, Edward N Timofeev

Artif DNA PNA XNA· July 2015

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Comparison of the 'chemical' and 'structural' approaches to the optimization of the thrombin-binding aptamer.
Olga Tatarinova, Vladimir Tsvetkov, Dmitry Basmanov, Nikolay Barinov, Igor Smirnov, Edward Timofeev

PLoS One· January 2015

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Synthesis, characterization and in vitro activity of thrombin-binding DNA aptamers with triazole internucleotide linkages.
Anna M Varizhuk, Vladimir B Tsvetkov, Olga N Tatarinova, Dmitry N Kaluzhny, Vladimir L Florentiev, Edward N Timofeev

Eur J Med Chem· September 2013

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Simple and stereoselective preparation of an 4-(aminomethyl)-1,2,3-triazolyl nucleoside phosphoramidite.
Natalia A Kolganova, Vladimir L Florentiev, Alexander V Chudinov, Alexander S Zasedatelev, Edward N Timofeev

Chem Biodivers· April 2011

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Oligonucleotide analogs with peptide internucleotide linkages.
Anna Varizhuk, Svetlana Kochetkova, Natalia Kolganova, Edward Timofeev, Vladimir Florentiev

Nucleosides Nucleotides Nucleic Acids· January 2011

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Oligodeoxynucleotides containing N1-methyl-2'-deoxyadenosine and N6-methyl-2'-deoxyadenosine.
Sergey N Mikhailov, Edward N Timofeev, Mikhail S Drenichev, Ekaterina V Efimtseva, Piet Herdewijn

Curr Protoc Nucleic Acid Chem· September 2009

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Recognition of base pair inversions in duplex by chimeric (alpha,beta) triplex-forming oligonucleotides.
Edward N Timofeev, Baira V Goryaeva, Vladimir L Florentiev

J Biomol Struct Dyn· October 2006

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