Publications by authors named "Edwin C Chow"

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Clinical Pharmacology of Glucagon.
Mohamad M Kronfol, Edwin C Chow, S W Johnny Lau, Mohamed I Nounou, Jayabharathi Vaidyanathan

Clin Pharmacol Ther· October 2024

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Strategies and limitations associated with in vitro characterization of vitamin D receptor activators.
Paola Bukuroshi, Hiroshi Saitoh, Lilia Magomedova, Carolyn L Cummins, Edwin C Chow

Biochem Pharmacol· September 2018

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Disrupted Murine Gut-to-Human Liver Signaling Alters Bile Acid Homeostasis in Humanized Mouse Liver Models.
Edwin C Y Chow, Holly P Quach, Yueping Zhang, Jason Z Y Wang, David C Evans

J Pharmacol Exp Ther· January 2017

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Using Physiologically Based Pharmacokinetic (PBPK) Modeling to Evaluate the Impact of Pharmaceutical Excipients on Oral Drug Absorption: Sensitivity Analyses.
Edwin Chiu Yuen Chow, Arjang Talattof, Eleftheria Tsakalozou, Jianghong Fan, Liang Zhao

AAPS J· November 2016

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Functional Integrity of the Chimeric (Humanized) Mouse Liver: Enzyme Zonation, Physiologic Spaces, and Hepatic Enzymes and Transporters.
Edwin C Y Chow, Jason Z Ya Wang, Holly P Quach, Hui Tang, David C Evans

Drug Metab Dispos· September 2016

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Physiologically-Based Pharmacokinetic-Pharmacodynamic Modeling of 1α,25-Dihydroxyvitamin D3 in Mice.
Vidya Ramakrishnan, Qi Joy Yang, Holly P Quach, Y Cao, Edwin C Y Chow

Drug Metab Dispos· February 2016

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PKPD modelling to predict altered disposition of 1α,25-dihydroxyvitamin D3 in mice due to dose-dependent regulation of CYP27B1 on synthesis and CYP24A1 on degradation.
Holly P Quach, Qi J Yang, Edwin C Chow, Donald E Mager, Stacie Y Hoi

Br J Pharmacol· July 2015

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PBPK modeling to unravel nonlinear pharmacokinetics of verapamil to estimate the fractional clearance for verapamil N-demethylation in the recirculating rat liver preparation.
Qi Joy Yang, Luqin Si, Hui Tang, Helle H Sveigaard, Edwin C Y Chow

Drug Metab Dispos· April 2015

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1α,25-Dihydroxyvitamin D3 reduces cerebral amyloid-β accumulation and improves cognition in mouse models of Alzheimer's disease.
Matthew R Durk, Kyung Han, Edwin C Y Chow, Rosemary Ahrens, Jeffrey T Henderson

J Neurosci· May 2014

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Vitamin D receptor activation down-regulates the small heterodimer partner and increases CYP7A1 to lower cholesterol.
Edwin C Y Chow, Lilia Magomedova, Holly P Quach, Rucha Patel, Matthew R Durk

Gastroenterology· April 2014

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Comparative effects of 1α-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 on transporters and enzymes in fxr(+/+) and fxr(-/-) mice.
Edwin C Y Chow, Matthew R Durk, Han-Joo Maeng, K Sandy Pang

Biopharm Drug Dispos· October 2013

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Temporal changes in tissue 1α,25-dihydroxyvitamin D3, vitamin D receptor target genes, and calcium and PTH levels after 1,25(OH)2D3 treatment in mice.
Edwin C Y Chow, Holly P Quach, Reinhold Vieth, K Sandy Pang

Am J Physiol Endocrinol Metab· May 2013

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Why we need proper PBPK models to examine intestine and liver oral drug absorption.
Edwin C Y Chow, K Sandy Pang

Curr Drug Metab· January 2013

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1α,25-Dihydroxyvitamin D3-liganded vitamin D receptor increases expression and transport activity of P-glycoprotein in isolated rat brain capillaries and human and rat brain microvessel endothelial cells.
Matthew R Durk, Gary N Y Chan, Christopher R Campos, John C Peart, Edwin C Y Chow

J Neurochem· December 2012

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Commentary: theoretical predictions of flow effects on intestinal and systemic availability in physiologically based pharmacokinetic intestine models: the traditional model, segregated flow model, and QGut model.
K Sandy Pang, Edwin C Y Chow

Drug Metab Dispos· October 2012

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1Alpha,25-dihydroxyvitamin D3 up-regulates P-glycoprotein via the vitamin D receptor and not farnesoid X receptor in both fxr(-/-) and fxr(+/+) mice and increased renal and brain efflux of digoxin in mice in vivo.
Edwin C Y Chow, Matthew R Durk, Carolyn L Cummins, K Sandy Pang

J Pharmacol Exp Ther· June 2011

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Comparative effects of doxercalciferol (1α-hydroxyvitamin D₂) versus calcitriol (1α,25-dihydroxyvitamin D₃) on the expression of transporters and enzymes in the rat in vivo.
Edwin C Y Chow, Myrte Sondervan, Cheng Jin, Geny M M Groothuis, K Sandy Pang

J Pharm Sci· April 2011

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1α,25-dihydroxyvitamin D3 on intestinal transporter function: studies with the rat everted intestinal sac.
Han-Joo Maeng, Matthew R Durk, Edwin C Y Chow, Ragia Ghoneim, K Sandy Pang

Biopharm Drug Dispos· March 2011

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The role of lithocholic acid in the regulation of bile acid detoxication, synthesis, and transport proteins in rat and human intestine and liver slices.
Ansar A Khan, Edwin C Y Chow, Robert J Porte, K Sandy Pang, Geny M M Groothuis

Toxicol In Vitro· February 2011

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PBPK modeling of intestinal and liver enzymes and transporters in drug absorption and sequential metabolism.
Jianghong Fan, Shu Chen, Edwin C Y Chow, K Sandy Pang

Curr Drug Metab· November 2010

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Effects of 1alpha,25-dihydroxyvitamin D3 on transporters and enzymes of the rat intestine and kidney in vivo.
Edwin C Y Chow, Huadong Sun, Ansar A Khan, Geny M M Groothuis, K Sandy Pang

Biopharm Drug Dispos· January 2010

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1alpha,25-Dihydroxyvitamin D(3) triggered vitamin D receptor and farnesoid X receptor-like effects in rat intestine and liver in vivo.
Edwin C Y Chow, Han-Joo Maeng, Shanjun Liu, Ansar A Khan, Geny M M Groothuis

Biopharm Drug Dispos· November 2009

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Expression and regulation of the bile acid transporter, OSTalpha-OSTbeta in rat and human intestine and liver.
Ansar A Khan, Edwin C Y Chow, Robert J Porte, K Sandy Pang, Geny M M Groothuis

Biopharm Drug Dispos· July 2009

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Comparison of effects of VDR versus PXR, FXR and GR ligands on the regulation of CYP3A isozymes in rat and human intestine and liver.
Ansar A Khan, Edwin C Y Chow, Anne-miek M A van Loenen-Weemaes, Robert J Porte, K Sandy Pang

Eur J Pharm Sci· May 2009

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The Caco-2 cell monolayer: usefulness and limitations.
Huadong Sun, Edwin Cy Chow, Shanjun Liu, Yimin Du, K Sandy Pang

Expert Opin Drug Metab Toxicol· April 2008

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