Publications by authors named "Edwin Zwart"

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Altered cytokine release of airway epithelial cells in vitro by combinations of respiratory syncytial virus, Streptococcus pneumoniae, Printex 90 and diesel exhaust particles.
Marcia M Oldenburger, Raiza Hasrat, Axel A Bonacic Marinovic, Eric R Gremmer, Edwin P Zwart

Environ Res· June 2025

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The zebrafish embryo as a model for chemically-induced steatosis: A case study with three pesticides.
Harm J Heusinkveld, Edwin P Zwart, Angela de Haan, Albert Braeuning, Jimmy Alarcan

Toxicology· November 2024

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Dose addition in mixtures of compounds with dissimilar endocrine modes of action in in vitro receptor activation assays and the zebrafish sexual development test.
Toine Fh Bovee, Harm J Heusinkveld, Sophie Dodd, Ad Peijnenburg, Deborah Rijkers, Edwin P Zwart

Food Chem Toxicol· February 2024

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Transferability and reproducibility of exposed air-liquid interface co-culture lung models.
Hedwig M Braakhuis, Eric R Gremmer, Anne Bannuscher, Barbara Drasler, Sandeep Keshavan, Edwin Zwart

NanoImpact· July 2023

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Prolonged Differentiation of Neuron-Astrocyte Co-Cultures Results in Emergence of Dopaminergic Neurons.
Victoria C de Leeuw, Conny T M van Oostrom, Edwin P Zwart, Harm J Heusinkveld, Ellen V S Hessel

Int J Mol Sci· February 2023

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An inter-laboratory effort to harmonize the cell-delivered in vitro dose of aerosolized materials.
Anne Bannuscher, Otmar Schmid, Barbara Drasler, Alain Rohrbasser, Hedwig M Braakhuis, Edwin P Zwart

NanoImpact· October 2022

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Dose Addition in the Induction of Craniofacial Malformations in Zebrafish Embryos Exposed to a Complex Mixture of Food-Relevant Chemicals with Dissimilar Modes of Action.
Leo T M Van Der Ven, Paul Van Ommeren, Edwin P Zwart, Eric R Gremmer, Hennie M Hodemaekers

Environ Health Perspect· April 2022

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Discovery and optimization of covalent EGFR T790M/L858R mutant inhibitors.
Niels Hoogenboom, Dennis Demont, Edwin de Zwart, Saskia Verkaik, Maaike Emmelot

Bioorg Med Chem Lett· November 2021

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Exploring Neurobehaviour in Zebrafish Embryos as a Screening Model for Addictiveness of Substances.
Anne Havermans, Edwin P Zwart, Hans W J M Cremers, Maarten D M van Schijndel, Romy S Constant

Toxics· October 2021

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Developmental Neurotoxicity of Environmentally Relevant Pharmaceuticals and Mixtures Thereof in a Zebrafish Embryo Behavioural Test.
Alessandro Atzei, Ingrid Jense, Edwin P Zwart, Jessica Legradi, Bastiaan J Venhuis

Int J Environ Res Public Health· June 2021

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Mutagenicity of N-hydroxy-4-aminobiphenyl in human TP53 knock-in (Hupki) mouse embryo fibroblasts.
Lisa Hölzl-Armstrong, Jill E Kucab, Edwin P Zwart, Mirjam Luijten, David H Phillips

Environ Mol Mutagen· April 2021

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Mutagenicity of 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine (N-OH-PhIP) in human TP53 knock-in (Hupki) mouse embryo fibroblasts.
Lisa Hölzl-Armstrong, Sarah Moody, Jill E Kucab, Edwin P Zwart, Medjda Bellamri

Food Chem Toxicol· January 2021

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Mutagenicity of acrylamide and glycidamide in human TP53 knock-in (Hupki) mouse embryo fibroblasts.
Lisa Hölzl-Armstrong, Jill E Kucab, Sarah Moody, Edwin P Zwart, Lucie Loutkotová

Arch Toxicol· December 2020

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The effects of aliphatic alcohols and related acid metabolites in zebrafish embryos - correlations with rat developmental toxicity and with effects in advanced life stages in fish.
Leo T M van der Ven, Willem G Schoonen, Renate M Groot, Fatima den Ouden, Harm J Heusinkveld, Edwin P Zwart

Toxicol Appl Pharmacol· November 2020

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Discovery of quinoline-based irreversible BTK inhibitors.
Gerjan de Bruin, Dennis Demont, Edwin de Zwart, Saskia Verkaik, Niels Hoogenboom

Bioorg Med Chem Lett· July 2020

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An Air-liquid Interface Bronchial Epithelial Model for Realistic, Repeated Inhalation Exposure to Airborne Particles for Toxicity Testing.
Hedwig M Braakhuis, Ruiwen He, Rob J Vandebriel, Eric R Gremmer, Edwin Zwart

J Vis Exp· May 2020

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Dose addition in chemical mixtures inducing craniofacial malformations in zebrafish (Danio rerio) embryos.
Maria Zoupa, Edwin P Zwart, Eric R Gremmer, Ananditya Nugraha, Sharon Compeer

Food Chem Toxicol· March 2020

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In vitro mammalian cell mutation assays based on transgenic reporters: A report of the International Workshop on Genotoxicity Testing (IWGT).
Paul A White, Mirjam Luijten, Masayuki Mishima, Julie A Cox, Joleen N Hanna, Edwin P Zwart

Mutat Res Genet Toxicol Environ Mutagen· November 2019

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The development and prevalidation of an in vitro mutagenicity assay based on MutaMouse primary hepatocytes, Part I: Isolation, structural, genetic, and biochemical characterization.
Julie A Cox, Edwin P Zwart, Mirjam Luijten, Paul A White

Environ Mol Mutagen· May 2019

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The development and prevalidation of an in vitro mutagenicity assay based on MutaMouse primary hepatocytes, Part II: Assay performance for the identification of mutagenic chemicals.
Julie A Cox, Edwin P Zwart, Mirjam Luijten, Paul A White

Environ Mol Mutagen· May 2019

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Head skeleton malformations in zebrafish (Danio rerio) to assess adverse effects of mixtures of compounds.
Yvonne C M Staal, Jeroen Meijer, Remco J C van der Kris, Annamaria C de Bruijn, Anke Y Boersma, Edwin P Zwart

Arch Toxicol· December 2018

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Is current risk assessment of non-genotoxic carcinogens protective?
Hedwig M Braakhuis, Wout Slob, Evelyn D Olthof, Gerrit Wolterink, Edwin P Zwart

Crit Rev Toxicol· July 2018

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Acalabrutinib (ACP-196): A Covalent Bruton Tyrosine Kinase Inhibitor with a Differentiated Selectivity and In Vivo Potency Profile.
Tjeerd Barf, Todd Covey, Raquel Izumi, Bas van de Kar, Michael Gulrajani, Edwin de Zwart

J Pharmacol Exp Ther· November 2017

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Evaluation of the LacZ reporter assay in cryopreserved primary hepatocytes for In vitro genotoxicity testing.
Mirjam Luijten, Edwin P Zwart, Martijn E T Dollé, Maaike de Pooter, Julie A Cox

Environ Mol Mutagen· December 2016

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TP53 and lacZ mutagenesis induced by 3-nitrobenzanthrone in Xpa-deficient human TP53 knock-in mouse embryo fibroblasts.
Jill E Kucab, Edwin P Zwart, Harry van Steeg, Mirjam Luijten, Heinz H Schmeiser

DNA Repair (Amst)· March 2016

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