Publications by authors named "Eiichi Tokuda"

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Diverse effects of coexpression of human SOD1 variants on motor neuron disease.
Eiichi Tokuda, Laura Leykam, Per Zetterström, Thomas Brännström, Peter M Andersen

Hum Mol Genet· August 2025

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MS785-MS27 Reactive Misfolded/Non-Native Zn-Deficient SOD1 Species Exhibit Cytotoxicity and Adopt Heterozygous Conformations in Motor Neurons.
Eiichi Tokuda, Yume Sakashita, Naoya Tokoro, Ayano Date, Yasuhiro Kosuge

Int J Mol Sci· May 2024

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FUS regulates RAN translation through modulating the G-quadruplex structure of GGGGCC repeat RNA in -linked ALS/FTD.
Yuzo Fujino, Morio Ueyama, Taro Ishiguro, Daisaku Ozawa, Hayato Ito, Eiichi Tokuda

Elife· July 2023

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Apoptotic Effects of a Thioether Analog of Vitamin K in a Human Leukemia Cell Line.
Satoru Asami, Mikana Suzuki, Toshimitsu Nakayama, Yasuyo Shimoda, Motofumi Miura, Eiichi Tokuda

Int J Toxicol· December 2021

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Stagnation of glymphatic interstitial fluid flow and delay in waste clearance in the SOD1-G93A mouse model of ALS.
Mikako Hirose, Mito Asano, Saori Watanabe-Matsumoto, Koji Yamanaka, Yoichiro Abe, Eiichi Tokuda

Neurosci Res· October 2021

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A Metal-Free, Disulfide Oxidized Form of Superoxide Dismutase 1 as a Primary Misfolded Species with Prion-Like Properties in the Extracellular Environments Surrounding Motor Neuron-Like Cells.
Chika Takashima, Yasuhiro Kosuge, Masahisa Inoue, Shin-Ichi Ono, Eiichi Tokuda

Int J Mol Sci· April 2021

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Does wild-type Cu/Zn-superoxide dismutase have pathogenic roles in amyotrophic lateral sclerosis?
Yoshiaki Furukawa, Eiichi Tokuda

Transl Neurodegener· August 2020

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Oxidative misfolding of Cu/Zn-superoxide dismutase triggered by non-canonical intramolecular disulfide formation.
Itsuki Anzai, Eiichi Tokuda, Sumika Handa, Hidemi Misawa, Shuji Akiyama

Free Radic Biol Med· February 2020

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Wild-type Cu/Zn-superoxide dismutase is misfolded in cerebrospinal fluid of sporadic amyotrophic lateral sclerosis.
Eiichi Tokuda, Yo-Ichi Takei, Shinji Ohara, Noriko Fujiwara, Isao Hozumi

Mol Neurodegener· November 2019

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[Prion-like Properties of Misfolded Cu/Zn-superoxide Dismutase in Amyotrophic Lateral Sclerosis: Update and Perspectives].
Eiichi Tokuda, Stefan L Marklund, Yoshiaki Furukawa

Yakugaku Zasshi· September 2019

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Cu/Zn-superoxide dismutase forms fibrillar hydrogels in a pH-dependent manner via a water-rich extended intermediate state.
Noriko Fujiwara, Michiru Wagatsuma, Naoto Oba, Daisaku Yoshihara, Eiichi Tokuda

PLoS One· March 2019

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A copper-deficient form of mutant Cu/Zn-superoxide dismutase as an early pathological species in amyotrophic lateral sclerosis.
Eiichi Tokuda, Takao Nomura, Shinji Ohara, Seiji Watanabe, Koji Yamanaka

Biochim Biophys Acta Mol Basis Dis· June 2018

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An essential role of N-terminal domain of copper chaperone in the enzymatic activation of Cu/Zn-superoxide dismutase.
Mami Fukuoka, Eiichi Tokuda, Kenta Nakagome, Zhiliang Wu, Isao Nagano

J Inorg Biochem· October 2017

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Aggregation of FET Proteins as a Pathological Change in Amyotrophic Lateral Sclerosis.
Yoshiaki Furukawa, Eiichi Tokuda

Adv Exp Med Biol· September 2017

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Abnormal protein oligomers for neurodegeneration.
Eiichi Tokuda, Yoshiaki Furukawa

Oncotarget· June 2017

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Regulatory Role of RNA Chaperone TDP-43 for RNA Misfolding and Repeat-Associated Translation in SCA31.
Taro Ishiguro, Nozomu Sato, Morio Ueyama, Nobuhiro Fujikake, Chantal Sellier, Eiichi Tokuda

Neuron· April 2017

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A misfolded dimer of Cu/Zn-superoxide dismutase leading to pathological oligomerization in amyotrophic lateral sclerosis.
Itsuki Anzai, Eiichi Tokuda, Atsushi Mukaiyama, Shuji Akiyama, Fumito Endo

Protein Sci· March 2017

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Immunochemical characterization on pathological oligomers of mutant Cu/Zn-superoxide dismutase in amyotrophic lateral sclerosis.
Eiichi Tokuda, Itsuki Anzai, Takao Nomura, Keisuke Toichi, Masahiko Watanabe

Mol Neurodegener· January 2017

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Screening of Drugs Inhibiting In vitro Oligomerization of Cu/Zn-Superoxide Dismutase with a Mutation Causing Amyotrophic Lateral Sclerosis.
Itsuki Anzai, Keisuke Toichi, Eiichi Tokuda, Atsushi Mukaiyama, Shuji Akiyama

Front Mol Biosci· August 2016

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Copper Homeostasis as a Therapeutic Target in Amyotrophic Lateral Sclerosis with SOD1 Mutations.
Eiichi Tokuda, Yoshiaki Furukawa

Int J Mol Sci· April 2016

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Low autophagy capacity implicated in motor system vulnerability to mutant superoxide dismutase.
Eiichi Tokuda, Thomas Brännström, Peter M Andersen, Stefan L Marklund

Acta Neuropathol Commun· January 2016

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Regulation of Intracellular Copper by Induction of Endogenous Metallothioneins Improves the Disease Course in a Mouse Model of Amyotrophic Lateral Sclerosis.
Eiichi Tokuda, Shunsuke Watanabe, Eriko Okawa, Shin-ichi Ono

Neurotherapeutics· April 2015

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Overexpression of metallothionein-I, a copper-regulating protein, attenuates intracellular copper dyshomeostasis and extends lifespan in a mouse model of amyotrophic lateral sclerosis caused by mutant superoxide dismutase-1.
Eiichi Tokuda, Eriko Okawa, Shunsuke Watanabe, Shin-Ichi Ono

Hum Mol Genet· March 2014

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Dysregulation of intracellular copper homeostasis is common to transgenic mice expressing human mutant superoxide dismutase-1s regardless of their copper-binding abilities.
Eiichi Tokuda, Eriko Okawa, Shunsuke Watanabe, Shin-Ichi Ono, Stefan L Marklund

Neurobiol Dis· June 2013

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Effects of pergolide mesilate on metallothionein mRNAs expression in a mouse model for Parkinson disease.
Shin-ichi Ono, Kohji Hirai, Ei-ichi Tokuda

Biol Pharm Bull· October 2009

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