Publications by authors named "Eike Spruth"

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CSF biomarkers of neuroinflammation are associated with regional atrophy.
Serap Özlü, Martin Dyrba, Alice Grazia, Frederic Brosseron, Katharina Buerger, Eike Jakob Spruth

J Neurol· December 2025

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A computational ontology framework for the synthesis of multi-level pathology reports from brain MRI scans.
Devesh Singh, Alice Grazia, Achim Reiz, Andreas Hermann, Slawek Altenstein, Eike J Spruth

J Alzheimers Dis· November 2025

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Speech-based digital cognitive assessments for detection of mild cognitive impairment: Validation against paper-based neurocognitive assessment scores.
Zampeta-Sofia Alexopoulou, Stefanie Köhler, Elisa Mallick, Johannes Tröger, Nicklas Linz, Eike Spruth

J Alzheimers Dis· November 2025

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Associations between digital speech features of automated cognitive tasks and trajectories of brain atrophy and cognitive decline in early Alzheimer's disease.
Qingyue Li, Stefanie Koehler, Alexandra Koenig, Martin Dyrba, Elisa Mallik, Eike Spruth

J Alzheimers Dis· September 2025

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Blood biomarkers confirm subjective cognitive decline (SCD) as a distinct molecular and clinical stage within the NIA-AA framework of Alzheimer´s disease.
David Mengel, Ester Soter, Julia Maren Ott, Madeleine Wacker, Alejandra Leyva, Eike Spruth

Mol Psychiatry· July 2025

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Disease stage-specific atrophy markers in Alzheimer's disease.
Hannah Baumeister, Helena M Gellersen, Sarah E Polk, René Lattmann, Anika Wuestefeld, Eike Spruth

Alzheimers Dement· July 2025

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Mini social cognition and emotional assessment: Diagnostic performance and neural correlates in behavioural-variant frontotemporal dementia.
Cem Doğdu, Neeraj Upadhyay, Ingo Frommann, Luca Kleineidam, Andreas Johnen, Eike Jakob Spruth

J Neuropsychol· June 2025

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The economic burden of subjective cognitive decline, mild cognitive impairment and Alzheimer's dementia: excess costs and associated clinical and risk factors.
Eva Gläser, Ingo Kilimann, Moritz Platen, Wolfgang Hoffmann, Frederic Brosseron, Eike Jakob Spruth

Alzheimers Res Ther· June 2025

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Application of IVDr NMR spectroscopy to stratify Parkinson's disease with absolute quantitation of blood serum metabolites and lipoproteins.
Georgy Berezhnoy, Gyuntae Bae, Leonie Wüst, Claudia Schulte, Claire Cannet, Eike Jakob Spruth

Sci Rep· May 2025

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Perivascular space and white matter hyperintensities in Alzheimer's disease: associations with disease progression and cognitive function.
Philine Marie Schirge, Robert Perneczky, Toshiaki Taoka, Adriana L Ruiz-Rizzo, Ersin Ersoezlue, Eike Spruth

Alzheimers Res Ther· March 2025

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Disease stage-specific atrophy markers in Alzheimer's disease.
Hannah Baumeister, Helena M Gellersen, Sarah E Polk, René Lattmann, Anika Wuestefeld, Eike Spruth

medRxiv· March 2025

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Linking higher amyloid beta 1-38 (Aβ(1-38)) levels to reduced Alzheimer's disease progression risk.
Luisa Sophie Schneider, Silka Dawn Freiesleben, Gerard van Breukelen, Xiao Wang, Frederic Brosseron, Eike Jakob Spruth

Alzheimers Dement· February 2025

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CSF biomarkers are differentially linked to brain areas high and low in noradrenaline, dopamine and serotonin across the Alzheimer's disease spectrum.
Lena Haag, Elisa Lancini, Renat Yakupov, Gabriel Ziegler, Yeo-Jin Yi, Eike Jakob Spruth

Brain Commun· January 2025

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Blood-based quantification of Aβ oligomers indicates impaired clearance from brain in ApoE ε4 positive subjects.
Lara Blömeke, Fabian Rehn, Marlene Pils, Victoria Kraemer-Schulien, Anneliese Cousin, Eike J Spruth

Commun Med (Lond)· December 2024

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Environmental enrichment is associated with favorable memory-related functional brain activity patterns in older adults.
Simon Hass, Maxie Liebscher, Anni Richter, Klaus Fliessbach, Christoph Laske, Eike Jakob Spruth

Front Aging Neurosci· December 2024

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Locus coeruleus signal intensity and emotion regulation in agitation in Alzheimer's disease.
Kathy Y Liu, Matthew J Betts, Dorothea Hämmerer, Emrah Düzel, Mara Mather, Eike J Spruth

Brain Commun· December 2024

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Author Correction: Whole-body metabolic modelling reveals microbiome and genomic interactions on reduced urine formate levels in Alzheimer's disease.
Filippo Martinelli, Almut Heinken, Ann-Kristin Henning, Maria A Ulmer, Tim Hensen, Eike Jakob Spruth

Sci Rep· November 2024

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Cognitive reserve against Alzheimer's pathology is linked to brain activity during memory formation.
Niklas Vockert, Judith Machts, Luca Kleineidam, Aditya Nemali, Enise I Incesoy, Eike Jakob Spruth

Nat Commun· November 2024

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GFAP and NfL as fluid biomarkers for clinical disease severity and disease progression in multiple system atrophy (MSA).
Sabrina Katzdobler, Georg Nübling, Martin Klietz, Urban M Fietzek, Carla Palleis, Eike Jakob Spruth

J Neurol· October 2024

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Association of Neurogranin and BACE1 With Clinical Cognitive Decline in Individuals With Subjective Cognitive Decline.
Xiao Wang, Silka D Freiesleben, Luisa-Sophie Schneider, Lukas Preis, Josef Priller, Eike J Spruth

Neurology· October 2024

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Longitudinal evidence for a mutually reinforcing relationship between white matter hyperintensities and cortical thickness in cognitively unimpaired older adults.
Jose Bernal, Inga Menze, Renat Yakupov, Oliver Peters, Julian Hellmann-Regen, Eike Jakob Spruth

Alzheimers Res Ther· October 2024

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Perivascular space enlargement accelerates in ageing and Alzheimer's disease pathology: evidence from a three-year longitudinal multicentre study.
Inga Menze, Jose Bernal, Pinar Kaya, Çağla Aki, Malte Pfister, Eike J Spruth

Alzheimers Res Ther· October 2024

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Amyloid and SCD jointly predict cognitive decline across Chinese and German cohorts.
Kai Shao, Xiaochen Hu, Luca Kleineidam, Melina Stark, Slawek Altenstein, Eike Jakob Spruth

Alzheimers Dement· September 2024

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Plasma amyloid beta X-42/X-40 ratio and cognitive decline in suspected early and preclinical Alzheimer's disease.
Jonathan Vogelgsang, Niels Hansen, Melina Stark, Michael Wagner, Hans Klafki, Eike Spruth

Alzheimers Dement· August 2024

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