Publications by authors named "El-Sayed Akool"

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Modulatory effect of metformin and its transporters on immune infiltration in tumor microenvironment: a bioinformatic study with experimental validation.
Ahmed A Rashad, Mohamed F Elshafie, Safwat A Mangoura, El-Sayed Akool

Discov Oncol· May 2025

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Molecular mechanisms of extracellular-ATP-mediated colorectal cancer progression: Implication of purinergic receptors-mediated nucleocytoplasmic shuttling of HuR.
Abdel-Aziz S Shatat, Elsayed M Mahgoup, Mohammed H Rashed, Ibrahim G Saleh, El-Sayed Akool

Purinergic Signal· December 2024

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Sorafenib and edaravone protect against renal fibrosis induced by unilateral ureteral obstruction via inhibition of oxidative stress, inflammation, and RIPK-3/MLKL pathway.
Mohamed A Abou Taha, Fares E M Ali, Ibrahim G Saleh, El-Sayed Akool

Naunyn Schmiedebergs Arch Pharmacol· November 2024

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P2 X 7 receptor is a critical regulator of extracellular ATP-induced profibrotic genes expression in rat kidney: implication of transforming growth factor-β/Smad signaling pathway.
Fatma Mounieb, Somaia A Abdel-Sattar, Amany Balah, El-Sayed Akool

Purinergic Signal· August 2024

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Hepatoprotective effects of carvedilol and crocin against leflunomide-induced liver injury.
Samia Salem Sokar, Mahmoud Abdelrahman Alkabbani, El-Sayed Akool, Sally El-Sayed Abu-Risha

Int Immunopharmacol· December 2022

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Concomitant Administration of Rosuvastatin and Lefleunamide in Low doses Synergize Against Complete Freunds Adjuvant (CFA)-Induced Rheumatoid Arthritis in Experimental Model.
Abdel-Aziz Saeed, Mohamed El-Shafey, Gouda K Helal, El-Sayed Akool

J Pharm Res Int· August 2021

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PEG-SOD attenuates the mitogenic ERK1/2 signaling cascade induced by cyclosporin A in the liver and kidney of albino mice.
Ahmed Yousef, I G Saleh, Adel R A Abd-Allah, Mohamed R Elnagar, El-Sayed Akool

Chem Biol Interact· October 2020

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Cyclosporin A activates human hepatocellular carcinoma (HepG2 cells) proliferation: implication of EGFR-mediated ERK1/2 signaling pathway.
Mohammed E Abo-El Fetoh, Gouda K Helal, I G Saleh, M Ewees, Mohamed ElShafey, El-Sayed Akool

Naunyn Schmiedebergs Arch Pharmacol· May 2020

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The potential antifibrotic impact of apocynin and alpha-lipoic acid in concanavalin A-induced liver fibrosis in rats: Role of NADPH oxidases 1 and 4.
Mostafa R Fayed, Reem N El-Naga, El-Sayed Akool, Ebtehal El-Demerdash

Drug Discov Ther· August 2019

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Vitamin E inhibits cyclosporin A-induced CTGF and TIMP-1 expression by repressing ROS-mediated activation of TGF-β/Smad signaling pathway in rat liver.
Amany Balah, Omnia Ezzat, El-Sayed Akool

Int Immunopharmacol· December 2018

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Propolis alleviates concanavalin A-induced hepatitis by modulating cytokine secretion and inhibition of reactive oxygen species.
Fatma Mounieb, Laila Ramadan, El-Sayed Akool, Amany Balah

Naunyn Schmiedebergs Arch Pharmacol· November 2017

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Molecular mechanisms of the protective role of wheat germ oil against cyclosporin A-induced hepatotoxicity in rats.
El-Sayed Akool

Pharm Biol· April 2016

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All-trans retinoic acid potentiates cisplatin-induced kidney injury in rats: impact of retinoic acid signaling pathway.
Abdelrahman M Elsayed, Tamer M Abdelghany, El-Sayed Akool, Abdel-Aziz H Abdel-Aziz, Mohamed S Abdel-Bakky

Naunyn Schmiedebergs Arch Pharmacol· March 2016

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Molecular mechanisms of PDGF-AA expression induced by the dsRNA-mimetic poly (I:C) and IL-18.
Amany Balah, Heiko Mühl, Josef Pfeilschifter, El-Sayed Akool

Biochem Biophys Res Commun· June 2013

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Cyclosporin A and tacrolimus induce renal Erk1/2 pathway via ROS-induced and metalloproteinase-dependent EGF-receptor signaling.
El-Sayed Akool, Stefan Gauer, Bashier Osman, Anke Doller, Sebastian Schulz

Biochem Pharmacol· January 2012

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Differential modulation of the cytokine-induced MMP-9/TIMP-1 protease-antiprotease system by the mTOR inhibitor rapamycin.
Bashier Osman, El-Sayed Akool, Anke Doller, Roswitha Müller, Josef Pfeilschifter

Biochem Pharmacol· January 2011

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Rapamycin induces the TGFbeta1/Smad signaling cascade in renal mesangial cells upstream of mTOR.
Bashier Osman, Anke Doller, El-Sayed Akool, Martin Holdener, Edith Hintermann

Cell Signal· December 2009

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The dsRNA-mimetic poly (I:C) and IL-18 synergize for IFNgamma and TNFalpha expression.
Amany Balah, El-Sayed Akool, Malte Bachmann, Josef Pfeilschifter, Heiko Mühl

Biochem Biophys Res Commun· November 2009

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Molecular mechanisms of nitric oxide-dependent inhibition of TPA-induced matrix metalloproteinase-9 (MMP-9) in MCF-7 cells.
Christine Jespersen, Anke Doller, El-Sayed Akool, Malte Bachmann, Roswitha Müller

J Cell Physiol· May 2009

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Molecular mechanisms of TGF beta receptor-triggered signaling cascades rapidly induced by the calcineurin inhibitors cyclosporin A and FK506.
El-Sayed Akool, Anke Doller, Andrea Babelova, Wasiliki Tsalastra, Kristin Moreth

J Immunol· August 2008

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Posttranslational modification of the AU-rich element binding protein HuR by protein kinase Cdelta elicits angiotensin II-induced stabilization and nuclear export of cyclooxygenase 2 mRNA.
Anke Doller, El-Sayed Akool, Andrea Huwiler, Roswitha Müller, Heinfried H Radeke

Mol Cell Biol· April 2008

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Modulation of mRNA stability as a novel therapeutic approach.
Wolfgang Eberhardt, Anke Doller, El-Sayed Akool, Josef Pfeilschifter

Pharmacol Ther· April 2007

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Molecular mechanisms of cyclosporin A inhibition of the cytokine-induced matrix metalloproteinase-9 in glomerular mesangial cells.
Anke Doller, El-Sayed Akool, Roswitha Müller, Paul Gutwein, Christine Kurowski

J Am Soc Nephrol· February 2007

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Nitric oxide induces TIMP-1 expression by activating the transforming growth factor beta-Smad signaling pathway.
El-Sayed Akool, Anke Doller, Roswitha Müller, Paul Gutwein, Cuiyan Xin

J Biol Chem· November 2005

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Dissociated glucocorticoids equipotently inhibit cytokine- and cAMP-induced matrix degrading proteases in rat mesangial cells.
Wolfgang Eberhardt, Tobias Kilz, El-Sayed Akool, Roswitha Müller, Josef Pfeilschifter

Biochem Pharmacol· August 2005

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