Publications by authors named "Elena MacFarlane"

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Transforming growth factor-beta (TGF-β) in the pathogenesis of hereditary thoracic aneurysm disorders.
Wendy A Espinoza Camejo, Emily E Bramel, Elena Gallo MacFarlane

Cardiovasc Pathol· November 2025

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Chemokine (C-C Motif) Ligand 2 Expressing Adventitial Fibroblast Expansion During Loeys-Dietz Syndrome Aortic Aneurysm Formation.
Alex R Dalal, Albert J Pedroza, Jennifer L Kim, Casey Gilles, Wenduo Gu, Elena G MacFarlane

Arterioscler Thromb Vasc Biol· May 2025

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Map2k6 is a potent genetic modifier of arterial rupture in vascular Ehlers-Danlos syndrome mice.
Caitlin J Bowen, Rebecca Sorber, Juan Francisco Calderón Giadrosic, Jefferson J Doyle, Graham Rykiel, Elena Gallo MacFarlane

JCI Insight· January 2025

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Intrinsic expression sensitizes the aortic root to dilation in a Loeys-Dietz syndrome mouse model.
Emily E Bramel, Wendy A Espinoza Camejo, Tyler J Creamer, Leda Restrepo, Muzna Saqib, Elena Gallo MacFarlane

Res Sq· June 2024

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Early clinical outcomes and molecular smooth muscle cell phenotyping using a prophylactic aortic arch replacement strategy in Loeys-Dietz syndrome.
Albert J Pedroza, Paul Cheng, Alex R Dalal, Kathrin Baeumler, Aya Kino, Elena Gallo MacFarlane

J Thorac Cardiovasc Surg· November 2023

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Postnatal Smad3 Inactivation in Murine Smooth Muscle Cells Elicits a Temporally and Regionally Distinct Transcriptional Response.
Emily E Bramel, Tyler J Creamer, Muzna Saqib, Wendy A Camejo Nunez, Rustam Bagirzadeh, Elena Gallo MacFarlane

Front Cardiovasc Med· April 2022

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Insights on the Pathogenesis of Aneurysm through the Study of Hereditary Aortopathies.
Tyler J Creamer, Emily E Bramel, Elena Gallo MacFarlane

Genes (Basel)· January 2021

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Calpain 9 as a therapeutic target in TGFβ-induced mesenchymal transition and fibrosis.
David H Kim, James D Beckett, Varun Nagpal, Manuel A Seman-Senderos, Russell A Gould, Elena Gallo MacFarlane

Sci Transl Med· July 2019

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Epigenetic activation and memory at a enhancer in systemic sclerosis.
Joseph Yusup Shin, James Daniel Beckett, Rustam Bagirzadeh, Tyler J Creamer, Ami A Shah, Elena G MacFarlane

Sci Transl Med· June 2019

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Oxytocin antagonism prevents pregnancy-associated aortic dissection in a mouse model of Marfan syndrome.
Jennifer Pardo Habashi, Elena Gallo MacFarlane, Rustam Bagirzadeh, Caitlin Bowen, Nicholas Huso

Sci Transl Med· May 2019

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Lineage-specific events underlie aortic root aneurysm pathogenesis in Loeys-Dietz syndrome.
Elena Gallo MacFarlane, Sarah J Parker, Joseph Y Shin, Benjamin E Kang, Shira G Ziegler

J Clin Invest· February 2019

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Decreased mitochondrial respiration in aneurysmal aortas of Fibulin-4 mutant mice is linked to PGC1A regulation.
Ingrid van der Pluijm, Joyce Burger, Paula M van Heijningen, Arne IJpma, Nicole van Vliet, Elena G MacFarlane

Cardiovasc Res· November 2018

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Proteomics reveals Rictor as a noncanonical TGF-β signaling target during aneurysm progression in Marfan mice.
Sarah J Parker, Aleksandr Stotland, Elena MacFarlane, Nicole Wilson, Amanda Orosco

Am J Physiol Heart Circ Physiol· November 2018

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TGF-β Family Signaling in Connective Tissue and Skeletal Diseases.
Elena Gallo MacFarlane, Julia Haupt, Harry C Dietz, Eileen M Shore

Cold Spring Harb Perspect Biol· November 2017

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Nonmyocyte ERK1/2 signaling contributes to load-induced cardiomyopathy in Marfan mice.
Rosanne Rouf, Elena Gallo MacFarlane, Eiki Takimoto, Rahul Chaudhary, Varun Nagpal

JCI Insight· August 2017

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Ectopic calcification in pseudoxanthoma elasticum responds to inhibition of tissue-nonspecific alkaline phosphatase.
Shira G Ziegler, Carlos R Ferreira, Elena Gallo MacFarlane, Ryan C Riddle, Ryan E Tomlinson

Sci Transl Med· June 2017

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