Publications by authors named "Eman A Fayed"

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Flufenamic acid-based sulfonohydrazide and acetamide derivatives NSAI as inhibitors of multi-targets COX-1/COX-2/5-LOX: design, synthesis, in silico ADMET and binding mode studies.
Shaimaa Hussein, Eman A Fayed, Ahmed Ragab, Moustafa S Abusaif, Yousry A Ammar

BMC Chem· October 2025

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Unlocking Therapeutic Potential of Novel Thieno-Oxazepine Hybrids as Multi-Target Inhibitors of AChE/BChE and Evaluation Against Alzheimer's Disease: In Vivo, In Vitro, Histopathological, and Docking Studies.
Khulood H Oudah, Mazin A A Najm, Triveena M Ramsis, Maha A Ebrahim, Nirvana A Gohar, Eman A Fayed

Pharmaceuticals (Basel)· August 2025

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Novel Pyrrolidine-bearing quinoxaline inhibitors of DNA Gyrase, RNA polymerase and spike glycoprotein.
Maha A Ebrahim, Triveena M Ramsis, Nirvana A Gohar, Shimaa A Metwally, Areej Rushdi, Eman A Fayed

Bioorg Chem· March 2025

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Discovery of novel bicyclic and tricyclic cyclohepta[b]thiophene derivatives as multipotent AChE and BChE inhibitors, in-Vivo and in-Vitro assays, ADMET and molecular docking simulation.
Eman A Fayed, Samiha Ahmed El-Sebaey, Maha A Ebrahim, Karema Abu-Elfotuh, Reda El-Sayed Mansour

Eur J Med Chem· February 2025

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Exploring a novel thiazole derivatives hybrid with fluorinated-indenoquinoxaline as dual inhibitors targeting VEGFR2/AKT and apoptosis inducers against hepatocellular carcinoma with docking simulation.
Moustafa S Abusaif, Ahmed Ragab, Eman A Fayed, Yousry A Ammar, Ayah M H Gowifel

Bioorg Chem· January 2025

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Fluorinated indeno-quinoxaline bearing thiazole moieties as hypoglycaemic agents targeting -amylase, and -glucosidase: synthesis, molecular docking, and ADMET studies.
Nirvana A Gohar, Eman A Fayed, Yousry A Ammar, Ola A Abu Ali, Ahmed Ragab

J Enzyme Inhib Med Chem· December 2024

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The role of current synthetic and possible plant and marine phytochemical compounds in the treatment of acne.
Triveena Ramsis, Heba Mohammed Refat M Selim, Howida Elseedy, Eman A Fayed

RSC Adv· July 2024

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Erratum to "Facile synthesis and in anticancer evaluation of a new series of tetrahydroquinoline" [Heliyon 7(10) (October 2021) e08117].
Usama Fathy, Hayam A Abd El Salam, Eman A Fayed, Abdelbaset M Elgamal, Ahmed Gouda

Heliyon· January 2024

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Interception of Epoxide ring to quorum sensing system in Enterococcus faecalis and Staphylococcus aureus.
Mohammed Y Refai, Ahmed M Elazzazy, Said E Desouky, Mohammed Abu-Elghait, Eman A Fayed

AMB Express· November 2023

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Development of new spiro[1,3]dithiine-4,11'-indeno[1,2-b]quinoxaline derivatives as S. aureus Sortase A inhibitors and radiosterilization with molecular modeling simulation.
Ahmed Ragab, Moustafa S Abusaif, Nirvana A Gohar, Dina S Aboul-Magd, Eman A Fayed

Bioorg Chem· February 2023

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The effect of novel synthetic semicarbazone- and thiosemicarbazone-linked 1,2,3-triazoles on the apoptotic markers, VEGFR-2, and cell cycle of myeloid leukemia.
Esraa M Othman, Eman A Fayed, Ebtehal M Husseiny, Hamada S Abulkhair

Bioorg Chem· October 2022

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Apoptosis induction, PARP-1 inhibition, and cell cycle analysis of leukemia cancer cells treated with novel synthetic 1,2,3-triazole-chalcone conjugates.
Esraa M Othman, Eman A Fayed, Ebtehal M Husseiny, Hamada S Abulkhair

Bioorg Chem· June 2022

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Upregulation of BAX and caspase-3, as well as downregulation of Bcl-2 during treatment with indeno[1,2-b]quinoxalin derivatives, mediated apoptosis in human cancer cells.
Eman A Fayed, Nirvana A Gohar, Amel M Farrag, Yousry A Ammar

Arch Pharm (Weinheim)· May 2022

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Secondary Metabolites of Actinomycetales as Potent Quorum Sensing Inhibitors Targeting Gram-Positive Pathogens: In Vitro and In Silico Study.
Said E Desouky, Mohammed Abu-Elghait, Eman A Fayed, Samy Selim, Basit Yousuf

Metabolites· March 2022

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One-Pot Synthesis and Molecular Modeling Studies of New Bioactive Spiro-Oxindoles Based on Uracil Derivatives as SARS-CoV-2 Inhibitors Targeting RNA Polymerase and Spike Glycoprotein.
Samar A El-Kalyoubi, Ahmed Ragab, Ola A Abu Ali, Yousry A Ammar, Mohamed G Seadawy, Eman A Fayed

Pharmaceuticals (Basel)· March 2022

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In vitro antimicrobial evaluation and in silico studies of coumarin derivatives tagged with pyrano-pyridine and pyrano-pyrimidine moieties as DNA gyrase inhibitors.
Eman A Fayed, Eman S Nosseir, Ahmed Atef, Samar A El-Kalyoubi

Mol Divers· February 2022

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In vivo screening and toxicity studies of indolinone incorporated thiosemicarbazone, thiazole and piperidinosulfonyl moieties as anticonvulsant agents.
Eman A Fayed, Ahmed Ragab, Rogy R Ezz Eldin, Ashraf H Bayoumi, Yousry A Ammar

Bioorg Chem· November 2021

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Hydrazonoyl bromide precursors as DHFR inhibitors for the synthesis of bis-thiazolyl pyrazole derivatives; antimicrobial activities, antibiofilm, and drug combination studies against MRSA.
Seham A Ibrahim, Eman A Fayed, Hala F Rizk, Said E Desouky, Ahmed Ragab

Bioorg Chem· November 2021

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Facile synthesis and anticancer evaluation of a new series of tetrahydroquinoline.
Usama Fathy, Hayam A Abd El Salam, Eman A Fayed, Abdelbaset M Elgamal, Ahmed Gouda

Heliyon· October 2021

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Novel structural hybrids of quinoline and thiazole moieties: Synthesis and evaluation of antibacterial and antifungal activities with molecular modeling studies.
Sally I Eissa, Amel M Farrag, Samir Y Abbas, Mohamed F El Shehry, Ahmed Ragab, Eman A Fayed

Bioorg Chem· May 2021

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In vivo and in vitro anti-inflammatory, antipyretic and ulcerogenic activities of pyridone and chromenopyridone derivatives, physicochemical and pharmacokinetic studies.
Eman A Fayed, Ashraf H Bayoumi, Aya S Saleh, Elham M Ezz Al-Arab, Yousry A Ammar

Bioorg Chem· April 2021

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Electrode impedance changes over time in MED El cochlear implant children recipients: Relation to stimulation levels and behavioral measures.
Eman Asaad Fayed, Hesham Saad Zaghloul, Ashraf Elsayed Morgan

Cochlear Implants Int· July 2020

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In vitro cytotoxic activity of thiazole-indenoquinoxaline hybrids as apoptotic agents, design, synthesis, physicochemical and pharmacokinetic studies.
Eman A Fayed, Yousry A Ammar, Ahmed Ragab, Nirvana A Gohar, Ahmed B M Mehany

Bioorg Chem· July 2020

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Antimicrobial evaluation of thiadiazino and thiazolo quinoxaline hybrids as potential DNA gyrase inhibitors; design, synthesis, characterization and morphological studies.
Yousry A Ammar, Awatef A Farag, Abeer M Ali, Sadia A Hessein, Ahmed A Askar, Eman A Fayed

Bioorg Chem· June 2020

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Design, synthesis, cytotoxicity and molecular modeling studies of some novel fluorinated pyrazole-based heterocycles as anticancer and apoptosis-inducing agents.
Eman A Fayed, Sally I Eissa, Ashraf H Bayoumi, Nirvana A Gohar, Ahmed B M Mehany

Mol Divers· February 2019

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