Publications by authors named "Emil Tykesson"

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Design of Glycosyltransferase Inhibitors: Targeting the Biosynthesis of Glycosaminoglycans by Phosphonate-Xyloside.
Daniel Willén, Hanna Malmquist, Pilar Blasco, Joachim Björklund, Roberto Mastio, Emil Tykesson

ACS Omega· December 2025

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Synthesis, conformational analysis and biological activity of xylopyranosyl sulfur-containing glycosides: dependence of sulfur atom configuration.
Pilar Blasco, Jonas Ståhle, Karin Thorsheim, Axel Furevi, Anna Siegbahn, Emil Tykesson

RSC Adv· May 2025

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Quantification of chondroitin sulfate, hyaluronic acid and -glycans in synovial fluid - A technical performance study.
Elin Andersson, Emil Tykesson, L Stefan Lohmander, Niclas G Karlsson, Chunsheng Jin

Osteoarthr Cartil Open· September 2023

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Production and HPLC-Based Disaccharide Analysis of Xyloside-Primed Glycosaminoglycans.
Andrea Persson, Emil Tykesson, Ulf Ellervik, Katrin Mani

Methods Mol Biol· January 2022

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Assays for Evaluation of Substrates for and Inhibitors of β-1,4-Galactosyltransferase 7.
Emil Tykesson, Andrea Persson, Katrin Mani, Ulf Ellervik

Methods Mol Biol· January 2022

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Azide-Functionalized Naphthoxyloside as a Tool for Glycosaminoglycan Investigations.
Daniel Willén, Roberto Mastio, Zackarias Söderlund, Sophie Manner, Gunilla Westergren-Thorsson, Emil Tykesson

Bioconjug Chem· December 2021

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Inhibition of iduronic acid biosynthesis by ebselen reduces glycosaminoglycan accumulation in mucopolysaccharidosis type I fibroblasts.
Marco Maccarana, Emil Tykesson, Edgar M Pera, Nadège Gouignard, Jianping Fang

Glycobiology· November 2021

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Fluorescently labeled xylosides offer insight into the biosynthetic pathways of glycosaminoglycans.
Roberto Mastio, Daniel Willén, Zackarias Söderlund, Gunilla Westergren-Thorsson, Sophie Manner, Emil Tykesson

RSC Adv· November 2021

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Harnessing the ECM Microenvironment to Ameliorate Mesenchymal Stromal Cell-Based Therapy in Chronic Lung Diseases.
Linda Elowsson Rendin, Anna Löfdahl, Måns Kadefors, Zackarias Söderlund, Emil Tykesson

Front Pharmacol· April 2021

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Chemoenzymatic Synthesis of Glycopeptides Bearing Galactose-Xylose Disaccharide from the Proteoglycan Linkage Region.
Jia Gao, Po-Han Lin, Setare Tahmasebi Nick, Junfeng Huang, Emil Tykesson

Org Lett· March 2021

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The structure of human dermatan sulfate epimerase 1 emphasizes the importance of C5-epimerization of glucuronic acid in higher organisms.
Mahmudul Hasan, Hamed Khakzad, Lotta Happonen, Anders Sundin, Johan Unge, Emil Tykesson

Chem Sci· February 2021

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Glycosaminoglycans: A Link Between Development and Regeneration in the Lung.
Jenny Wigén, Linda Elowsson-Rendin, Lisa Karlsson, Emil Tykesson, Gunilla Westergren-Thorsson

Stem Cells Dev· July 2019

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Recombinant dermatan sulfate is a potent activator of heparin cofactor II-dependent inhibition of thrombin.
Emil Tykesson, Marco Maccarana, Hanna Thorsson, Jian Liu, Anders Malmström

Glycobiology· June 2019

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Dermatan sulfate epimerase 1 and dermatan 4--sulfotransferase 1 form complexes that generate long epimerized 4--sulfated blocks.
Emil Tykesson, Antti Hassinen, Katarzyna Zielinska, Martin A Thelin, Giacomo Frati

J Biol Chem· August 2018

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Synthesis of Double-Modified Xyloside Analogues for Probing the β4GalT7 Active Site.
Daniel Willén, Dennis Bengtsson, Sebastian Clementson, Emil Tykesson, Sophie Manner

J Org Chem· February 2018

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Naphthyl Thio- and Carba-xylopyranosides for Exploration of the Active Site of β-1,4-Galactosyltransferase 7 (β4GalT7).
Karin Thorsheim, Daniel Willén, Emil Tykesson, Jonas Ståhle, Jean-Pierre Praly

Chemistry· December 2017

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Increased deposition of glycosaminoglycans and altered structure of heparan sulfate in idiopathic pulmonary fibrosis.
Gunilla Westergren-Thorsson, Ulf Hedström, Annika Nybom, Emil Tykesson, Emma Åhrman

Int J Biochem Cell Biol· February 2017

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The Tyrosine Kinase Inhibitor Imatinib Augments Extracellular Fluid Exchange and Reduces Average Collagen Fibril Diameter in Experimental Carcinoma.
P Olof Olsson, Renata Gustafsson, René In 't Zandt, Tomas Friman, Marco Maccarana, Emil Tykesson

Mol Cancer Ther· October 2016

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Determination of 3'-phosphoadenosine-5'-phosphosulfate in cells and Golgi fractions using hydrophilic interaction liquid chromatography-mass spectrometry.
Rua Kareem Dowood, Ravi Adusumalli, Emil Tykesson, Elin Johnsen, Elsa Lundanes

J Chromatogr A· October 2016

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Xyloside-primed Chondroitin Sulfate/Dermatan Sulfate from Breast Carcinoma Cells with a Defined Disaccharide Composition Has Cytotoxic Effects in Vitro.
Andrea Persson, Emil Tykesson, Gunilla Westergren-Thorsson, Anders Malmström, Ulf Ellervik

J Biol Chem· July 2016

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Dermatan Sulfate-Free Mice Display Embryological Defects and Are Neonatal Lethal Despite Normal Lymphoid and Non-Lymphoid Organogenesis.
Xanthi N Stachtea, Emil Tykesson, Toin H van Kuppevelt, Ricardo Feinstein, Anders Malmström

PLoS One· June 2016

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Disubstituted naphthyl β-D-xylopyranosides: Synthesis, GAG priming, and histone acetyltransferase (HAT) inhibition.
Karin Thorsheim, Andrea Persson, Anna Siegbahn, Emil Tykesson, Gunilla Westergren-Thorsson

Glycoconj J· April 2016

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Deciphering the Mode of Action of the Processive Polysaccharide Modifying Enzyme Dermatan Sulfate Epimerase 1 by Hydrogen-Deuterium Exchange Mass Spectrometry.
Emil Tykesson, Yang Mao, Marco Maccarana, Yi Pu, Jinshan Gao

Chem Sci· February 2016

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Versican in inflammation and tissue remodeling: the impact on lung disorders.
Annika Andersson-Sjöland, Oskar Hallgren, Sara Rolandsson, Maria Weitoft, Emil Tykesson

Glycobiology· March 2015

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Exploration of the active site of β4GalT7: modifications of the aglycon of aromatic xylosides.
Anna Siegbahn, Karin Thorsheim, Jonas Ståhle, Sophie Manner, Christoffer Hamark, Emil Tykesson

Org Biomol Chem· March 2015

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