Publications by authors named "Emile Verhulst"

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Selective and Orally Bioavailable Dipeptidyl Peptidase 9 Inhibitors with Potent Pyroptosis Induction Properties.
Nicolò Filippi, Kathleen Mertens, Joni De Loose, Siham Benramdane, Robin Hermans, Emile Verhulst

J Med Chem· November 2025

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Structure-Property Investigation of New "KetoFAPI" Inhibitors of Fibroblast Activation Protein (FAP): Discovery of Highly Potent, Selective Compounds with Prolonged Residence Times and Promising Radiotheranostic Potential.
Pawel Brzeminski, Emile Verhulst, Adrian Fabisiak, Roberta Pacifico, Daan Willocx

J Med Chem· October 2025

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Synthesis and Preclinical Evaluation of Druglike F-Labeled Fibroblast Activation Protein (FAP) Inhibitors with Enhanced Tumor Retention.
Karuna Adhikari, Sergei Grintsevich, Anke de Groot, Emile Verhulst, Yentl van Rymenant

Bioconjug Chem· August 2025

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Fibroblast activation protein on human natural killer cells: insights from natural killer cell activation and crosstalk with cancer-associated fibroblasts.
Yentl Van Rymenant, Anke de Groot, Laura Dirkx, Emile Verhulst, Joni De Loose

J Leukoc Biol· July 2025

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Human Transmembrane Serine Protease 2 (TMPRSS2) on Human Seminal Fluid Extracellular Vesicles Is Proteolytically Active.
Emile Verhulst, Michelle De Bruyn, Pascale Berckmans, Yani Sim, Koen Augustyns

J Extracell Vesicles· March 2025

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Intercellular interaction between FAP+ fibroblasts and CD150+ inflammatory monocytes mediates fibrostenosis in Crohn's disease.
Bo-Jun Ke, Saeed Abdurahiman, Francesca Biscu, Gaia Zanella, Gabriele Dragoni, Emile Verhulst

J Clin Invest· July 2024

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Druglike, F-labeled PET Tracers Targeting Fibroblast Activation Protein.
Muhammet Tanc, Nicolò Filippi, Yentl Van Rymenant, Sergei Grintsevich, Isabel Pintelon, Emile Verhulst

J Med Chem· May 2024

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Active site-directed probes targeting dipeptidyl peptidases 8 and 9.
Margarida Espadinha, Joni De Loose, Sam Corthaut, Sofie Thys, Yentl Van Rymenant, Emile Verhulst

Eur J Med Chem· April 2024

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Novel Generation of FAP Inhibitor-Based Homodimers for Improved Application in Radiotheranostics.
Marcel Martin, Sanjana Ballal, Madhav Prasad Yadav, Chandrasekhar Bal, Yentl Van Rymenant, Emile Verhulst

Cancers (Basel)· March 2023

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Validating Cell Surface Proteases as Drug Targets for Cancer Therapy: What Do We Know, and Where Do We Go?
Emile Verhulst, Delphine Garnier, Ingrid De Meester, Brigitte Bauvois

Cancers (Basel)· January 2022

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